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To assess the role of CHCHD2 variants in patients with Parkinson disease (PD) and Lewy body disease (LBD) in Caucasian populations.

Popular Abstract in Swedish Tillväxtfaktorer påverkar signaler mellan celler i hjärnan Människors hjärnor innehåller flera miljarder hjärnceller, vilka är förutsättningen för vårt beteende, våra känslor och våra tankar. Hjärncellerna bildar kontakter, synapser, med varandra. Genom dessa överförs signaler från en cell till en annan. Varje cell kontaktar en mängd andra celler, både sådana med liknanThe neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. Such plasticity is believed to be a cellular correlate for important processes like learning, but also for diseases, for

Hits from an in silico derived focused library for CRTH2 were transformed into highly selective antagonists with favorable ADME properties. Oral administration of 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid (19) inhibited peribronchial eosinophilia and mucus cell hyperplasia in a mouse model of allergic asthma, supporting the therapeutic potential of this novel compound class. In

Recently substantial research has been devoted to Unmanned Aerial Vehicles (UAVs). One of a UAV's most demanding subsystem is vision. The vision subsystem must dynamically combine different algorithms as the UAVs goal and surrounding change. To fully utilize the available hardware, a run time system must be able to vary the quality and the size of regions the algorithms are applied to, as the numb

BACKGROUND: Maternally derived duplications of the 15q11-q13 region are the most frequently reported chromosomal aberrations in autism spectrum disorders (ASD).Prader-Willi and Angelman syndromes, caused by 15q11-q13 deletions or abnormal methylation of imprinted genes, are also associated with ASD. However, the prevalence of these disorders in ASD is unknown. The aim of this study was to assess t

This paper reports on research on the engagement of ISO 14001 certified companies in environmental supply chain management, the drivers and barriers that influence their involvement, and how these forces correspond to the internal environmental management activities. In parallel, the issues of internal capabilities of companies, crucial for companies to respond to such driving forces, are highligh

For years tools and techniques such as Brainstorming, Mind-Maps and Rich Pictures have been used in both academic and professional practices to assist people with making sense of complex problem spaces. These tools have their supporters and in many cases their uses can be argued to be interchangeable. Seldom however have they been systematically applied in combination in theory or practice. Even t

Computers are increasingly used for implementing controlalgorithms in safety-critical embedded applications, such asengine control, braking control and flight surfacecontrol. Addressing the consequent coupling of control performancewith computer related errors, this paper develops a composite computerdependability/control theory methodology for analyzing the effectsdata errors have on control syst

Abstract in Undetermined This work tackles the problem of interferometric phase estimation in the presence of layover by using nonuniform multibaseline interferometric synthetic aperture radar systems. The effects of nonuniform sampling on Fourier-based and superresolution spectral estimation methods are investigated. The impact on both the spectral properties and on the interferometric phase esti