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In this presentation I discuss modern psychiatry, esp. neuropsychiatry, from the perspectives of philosophy and sociology of science. It is argued that there exist a number of tensions and ‘incommensurabilities’ in the field that are hard to overcome, thus giving rise to controversies. I separate four types of tensions, belonging to different ‘boxes.’ The first is called cognitive/internal, compri

Homeostasis of short-lived blood cells is dependent on rapid proliferation of immature precursors. Using a conditional histone 2B-mCherry-labeling mouse model, we characterize hematopoietic stem cell (HSC) and progenitor proliferation dynamics in steady state and following several types of induced stress. HSC proliferation following HSC transplantation into lethally irradiated mice is fundamentall

Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants.

Purpose: To quantify fixation stability in patients with neovascular age-related macular degeneration (nAMD) at baseline, 3 and 6 months after anti-vascular endothelial growth factor (anti-VEGF) treatment and furthermore asses the implications of an unsteady fixation for multifocal electroretinography (mfERG) measurements. Methods: Fifty eyes of 50 nAMD patients receiving intravitreal anti-VEGF tr

Aims/hypothesis: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Methods: Families from the

Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. Methods: Association

This research is triggered by the emerging ‘power by the hour’® paradigm, in which aero engines are effectively leased to airlines, with the manufacturing company remaining responsible for their maintenance and repair throughout their service life. By incorporating knowledge about the performance of existing products into the design phase of new products, it is hoped to tackle some of the in-servi

Packaging logistics is fundamental to the success of retail supply chains. Implementing systemwide change in this field is however complex. This paper introduces packaging logistics in retail supply chains and compares and contrasts the change processes in the introduction of plastic trays to retail food systems in the UK and Sweden.

Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important

Our society is becoming more and more dependent upon the reliable function of a number of vital socio-technical systems. These systems are often being referred to as critical infrastructures, or lifeline systems, indicating their importance for supporting a nation’s economy and social well-being. In the present paper a method is presented for assessing the capability of those actors involved in re

Religious argumentation is sometimes supposed to be different from other kinds of argumentation. George Kennedy for example mentions a radical Christian rhetoric in which the message is proclaimed rather than argued, but in my study of Paul’s first letter to the Corinthians I have found deliberate argumentation. This argumentation can be analyzed with Toulmin’s model of argumentation. The warrants