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Occupational exposure to chemicals and particles and incidence of myocardial infarction—a nationwide cohort study in Sweden

Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c

Paleolithic diet fraction and score in post hoc data analysis of a randomized controlled trial with lifestyle interventions for abdominal obesity

Background: Paleolithic Diet Fraction (PDF) and Paleolithic Diet Score (PDS) are both measures of how closely a food intake conforms to a Paleolithic dietary pattern. PDF is calculated directly from an individual’s absolute food intake and PDS is an aggregated score based on an individual’s food intake relative to a population. Both are inversely associated with all-cause and cause-specific mortal

Experiences of navigating anticipations and anxiety among patients having surgery for peripheral nerve tumours

Peripheral nerve tumours, most commonly schwannomas and neurofibromas, might present significant challenges by eliciting physical symptoms and emotional distress. We aimed to explore patients’ expectations, perceptions, and experiences regarding their diagnosis and the surgical treatment of a nerve tumour in the upper limb. Fourteen adults (10 women, 4 men; age range 35–85) from two Swedish hand s

Prospective Randomized Clinical Trial Comparing Paclitaxel-Coated Balloon Versus Conventional Balloon Angioplasty in Treating Below the Knee Arterial Lesions in Chronic Limb Threatening Ischemia: The CRURAL DEB Study

Objective: Drug-coated balloons (DCB) might improve the results of below the knee (BTK) angioplasty, but sufficient randomized data comparing DCB and conventional angioplasty in treating patients with chronic limb threatening ischemia (CLTI) are lacking. This study aimed to perform a randomized comparison between a paclitaxel-coated angioplasty balloon catheter and a conventional balloon angioplas

Associations between air pollution and relative leukocyte telomere length among northern Swedish adults based on findings from the Betula study

Air pollution is increasingly discussed as a risk factor for dementia, but the biological mechanisms are not yet fully understood. Biological markers like telomere length are relevant to study with air pollution, as they are associated with aging and dementia. The study aimed to investigate the relationship between source-specific air pollution exposure and telomere length in a low-level air pollu

Single-Cell Density Mapping and Acoustic Self-Organization in Microfluidic Systems

This thesis presents four interconnected studies showing methods for characterizing and separating cells based on their acoustic properties, with particular focus on isolating rare cells from blood samples.The first study introduces a technique for single-cell density measurements using microcapillary-adapted density gradient centrifugation. Using fluorescent markers to visualize the density gradi

Quantum Stochastic Communication via High-Dimensional Entanglement

Entanglement has the ability to enhance the transmission of classical information over a quantum channel. However, fully harvesting this advantage typically requires complex entangling measurements, which are challenging to implement and scale with the system's size. In this Letter, we consider a natural quantum information primitive known as a random access code in which the message to be communi

Offspring exposure to Crohn's disease during pregnancy and association with milder psychiatric regulatory disturbances in childhood

Introduction: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. Material and Methods: We conducted a populati

Higher-dimensional symmetric informationally complete measurement via programmable photonic integrated optics

Symmetric informationally complete measurements are both important building blocks in many quantum information protocols and the seminal example of a generalized, non-orthogonal, and quantum measurement. In higher-dimensional systems, these measurements become both increasingly interesting and increasingly complex to implement. Here, we demonstrate an integrated quantum photonic platform, operatin

Association of multiple symptoms with sleep quality and duration: a cross-sectional population-based study of older men in Sweden

Objective To evaluate any association of the presence and severity of nine major symptoms (pain, tiredness, drowsiness, nausea, appetite, breathlessness, depression, anxiety, and perceived well-being) with sleep quality and duration in elderly men.Design and setting Cross-sectional analysis within the population-based VAScular and Chronic Obstructive Lung disease study (VASCOL) conducted in southe

Non-Fullerene Naphthalene Diimide-Based Electron-Transport Materials for High-Performance and Stable Perovskite Solar Cells

Halide perovskite solar cells (PSCs) have emerged as a transformative photovoltaic technology, achieving unprecedented power conversion efficiencies. However, the development of electron-transport materials (ETMs), particularly organic ETMs, has significantly trailed behind the rapid progress in hole-transport materials (HTMs). Among the organic ETMs, naphthalene diimide (NDI)-based systems stand

Income-related mortality inequality and macroeconomic conditions

This study examines the relationship between income-related health inequality (IRHI) and macroeconomic conditions. We complement an income group-based analysis of the impact of macroeconomic conditions on mortality by incorporating an analysis of the concentration index as a comprehensive measure of overall IRHI. Using a recentered influence function regression approach, we estimate the impact of

Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte development

Stage- and lineage-specific gene expression patterns are controlled by a complex interplay between transcription factors, the epigenetic landscape, and the three-dimensional (3D) structure of the DNA. The 3D structure allows for the formation of DNA loops that juxtaposition distal regulatory elements to the promoters, allowing for tight control of gene expression. Developing a tool to facilitate t

Equivalent fully coupled modeling and experimental validation of high-particle-concentration acoustofluidics

Acoustofluidic particle manipulation has attracted considerable interest in biomedical applications due to its non-contact and label-free characteristics. However, existing computational models for predicting particle motion in acoustofluidic systems mainly focus on single-particle behavior, often neglecting particle–particle interactions and the impact of particle distribution on the acoustic and

Entropy value regulation of lanthanide perovskite catalysts : Unlocking the performance code of methanol reforming for hydrogen production

Hydrogen energy plays a pivotal role in the sustainable energy transition. Methanol steam reforming offers an efficient route for decentralized hydrogen production, yet catalyst limitations persist. This work employs entropy engineering to design lanthanide perovskite catalysts via sol-gel synthesis. Structural analyses reveal entropy-driven lattice distortion, enhanced disorder, and elevated oxyg

Multidimensional Decomposition and Ensemble Modeling of Histatin 1 and Its Siblings : Detailing Structure and Biological Function Using an Integrative Approach

Histatins are a family of multifunctional, cationic histidine-rich saliva peptides. The most prominently represented are Histatin 1, Histatin 3, and Histatin 5. Despite considerable similarities in primary structure, the three members are known to display varied antimicrobial properties and healing abilities. This study aims to provide a detailed structural comparison of Histatin 1, Histatin 3, an

Challenges to estimating and managing risks with hexavalent chromium exposure : A mixed-methods study of Swedish workplaces

Using a mixed-methods approach, we assessed understanding of risks from exposure to the non-threshold carcinogen hexavalent chromium (Cr(VI)) among workers (n = 113) and occupational health and safety managers (n = 13) at 14 worksites with potential exposure to Cr(VI). We found that 55% of the workers had a measurable concentration of inhalable Cr(VI), with 19% exceeding 1 µg/m3, a level that corr

Effects of the choice of the continuous phase in droplet microfluidics on internal particle manipulation with acoustophoresis

In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee

Så påverkar klimat­förändringar folkhälsan i Sverige och världen

Climate change is already impacting our environment and health, with rising sea levels, extreme weather, and higher temperatures. Greenhouse gas levels are at their highest in three million years, making climate-related health risks increasingly urgent. Heatwaves, wildfires, and floods lead to mortality, trauma, and non-communicable diseases both in the short and long term. Climate change also alt

Prepare-and-Measure Scenarios with Photon-Number Constraints

We study correlations in the prepare-and-measure scenario when quantum communication is constrained by photon-number statistics. Such constraints are natural and practical control parameters for semi-device-independent certification in optical platforms. To analyse these scenarios, we show how semidefinite programming relaxations for noncommutative polynomial optimization can be used to bound the