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Acute promyelocytic leukemia (APL) results from a chromosomal translocation that gives rise to the leukemogenic fusion protein PML-RAR alpha (promyelocytic leukemia-retinoic acid alpha receptor). Differentiation of leukemic cells and complete remission of APL are achieved by treatment of patients with pharmacological doses of all-trans retinoic acid (ATRA), making APL a model disease for different

OBJECTIVE-Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired beta-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS-We have conducted a meta-analysis of genome-wide as

OBJECTIVE Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested if a GRS based on an updated list of 34 type 2 diabetes-associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes Prev

Immunological data show that type 2 diabetes (T2D) manifests autoimmune features. We wanted to test the association epidemiologically by assessing subsequent diagnosis of T2D following diagnosis of autoimmune disease (AId) and subsequent AId after T2D in the same individuals. Patients were identified from three Swedish health databases. A total of 32 different AId were included. Standardized incid

Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of lepti

OBJECTIVE-Metformin produced weight loss and delayed or prevented diabetes in the Diabetes Prevention Program (DPP). We examined its long-term safety and tolerability along with weight loss, and change in waist circumference during the DPP and its long-term follow-up. RESEARCH DESIGN AND METHODS-The randomized double-blind clinical trial of metformin or placebo followed by a 7-8-year open-label ex

Several studies have reported associations between restricted fetal development, as shown by birth weight or birth length, and later ischaemic heart disease (IHD). However, few studies have examined the importance of these perinatal factors when taking into account gestational age at birth, hereditary factors, sociodemographic factors and comorbidities. This study investigated the importance of pe

Beulens JWJ, van der Schouw YT, Bergmann MM, Rohrmann S, B Schulze M, Buijsse B, Grobbee DE, Arriola L, Cauchi S, Tormo M-J, Allen NE, van der A DL, Balkau B, Boeing H, Clavel-Chapelon F, de Lauzon-Guillan B, Franks P, Froguel P, Gonzales C, Halkjaer J, Huerta JM, Kaaks R, Key TJ, Khaw KT, Krogh V, Molina-Montes E, Nilsson P, Overvad K, Palli D, Panico S, Ramon Quiros J, Ronaldsson O, Romieu I, Ro

In untreated patients with Alzheimer disease (AD) the functional ability is gradually lost. What happens to the patients after continuous long-term cholinesterase inhibitor (ChEI) treatment is less investigated. The objective of this study was to describe the longitudinal functional outcome and analyze factors affecting the outcome in ChEI-treated patients. In an open, 3-year, nonrandomized, prosp

Syftet med denna studie är att ur ett livsvärldsfenomenologiskt perspektiv dokumentera sång-ares upplevelse av sitt sångtekniska och musikaliska lärande i grupp och i förekommande fall sätta detta i relation till deras upplevelse av en enskild undervisning, samt att studera vilka faktorer som kan ha varit utslagsgivande för dessa upplevelser. Studien är kvalitativ och genomfördes som aktionsforsknTitle: Individual development in group - voice lessons together with and through others. The purpose of this study is to, from a life-world phenomenological point of view, document how singers experience their vocal technical and musical learning in group and in to relate this to their experience of a private lesson and to study what factors have been decisive for these experiences. This study is

Syftet med denna uppsats var att undersöka huruvida ett nationalekonomiskt perspektiv, genom kostnads-intäktsanalys, kan bidra till att bredda diskussionen om Kriminalvården och dess effektiviseringsarbete. De mått som idag används för att beskriva fångvårdens effektivitet utgörs av bl.a. återfallsbrottslighet, påbörjade samt avslutade behandlingsprogram och antalet rymningar från anstalt. Ingen e

Enligt vår empiri kan lärande uppstå även i nätverk som inte är skapade med grundtanke att lära. Nätverksplattformen är en viktig grund för att lärandet ska kunna utvecklas, vi ser dock lite annorlunda på tid och resurser då teorin säger att den är tidskrävande, medan vi menar motsatsen. Vi anser även att Nätverksplattformen behöver kompletteras. Här utgör bland annat struktur och rutiner en vikti

Syftet med uppsatsen är att utreda hur en organisation kan främja och tillvarata sin kreativa potential. För att finna svar på frågeställningen tog vi till en början till oss litteratur inom kreativitets-, organisations- och förändringsområdena och identifierade därigenom åtta viktiga, återkommande faktorer för att främja och tillvarata kreativitet. Dessa är vision, kontinuitet, delaktighet, mångf

To introduce a standardized component assortment takes a lot of effort in order to make real cost savings. The rationalization effect itself is important, but perhaps even more important is to state the aim of the standardization efforts in a well-defined way. How can an organization assure that they are working in a proper way? How do they know that their efforts are being interpreted into the wh

This bachelor thesis’ ambition is to unravel the rights discourse in the first female emancipatory journal in Sweden during the journal’s first decade 1859-1869. The Swe-dish female rights movement is during this time period unorganized and hence Tidskrift för hemmet became the first forum where a female emancipatory debate took place. By using a conceptual history analysis with philological eleme

The farmers in Sooriyawewa D.S. division, situated in the Dry Zone in Sri Lanka, are main cultivators of paddy and banana. The agriculture in the Dry Zone is heavily depending on water from the irrigation schemes. The objective of the study is to investigate the methods used in the paddy and banana cultivation in Sri Lanka with focus on Sooriyawewa D.S. division in order to understand the main con

In the native bovine casein micelle the calcium sensitive caseins (alpha(S1)-, alpha(S2)- and beta-casein) sequester amorphous calcium phosphate in nanometer-sized clusters, whereas the calcium-insensitive K-casein limits the growth of the micelle. In this paper, we further investigate the self-association of kappa- and beta-casein, which are two of the key proteins that control the substructure o

In Alzheimer's disease (AD), placebo-controlled long-term studies of cholinesterase inhibitors (ChEIs) are not permitted for ethical reasons. Therefore, in these studies, patients' outcomes on cognitive and functional assessment scales must be compared with mathematical models or historical data from untreated cohorts. PubMed and previously published long-term extensions of clinical trials and nat