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The efficacy of bendamustine versus chlorambucil in a phase III trial of previously untreated patients with Binet stage B/C chronic lymphocytic leukaemia (CLL) was re-evaluated after a median observation time of 54months in May 2010. Overall survival (OS) was analysed for the first time. At follow-up, investigator-assessed complete response (CR) rate (21.0% vs 10.8%), median progression-free survi

rs7629265 and AF Risk ObjectiveWe examined the association of rs7626962 (S1103Y) or rs7629265, a variant in high linkage disequilibrium with S1103Y (r(2) = 0.87 - 1), with sudden cardiac death (SCD) and atrial fibrillation (AF) among African Americans. BackgroundThe SCN5A missense variant S1103Y has been associated with SCD among African Americans in small case-control studies, but larger populati

I denna C-uppsats undersöker jag hur svensk folkmusik- och dans kan berika rytmikmetoden. Rytmikmetoden är mitt huvudämne och utgångspunkten för studien och uppsatsen innehåller därför en historisk översikt över rytmikmetodens utveckling från grundaren Jaques-Dalcroze till idag. Jag förklarar även grundläggande principer, metod och innehåll i rytmikmetoden för att göra jämförelsen med undervisningTitle: Music in motion- An interview study on how Swedish folk music and dance can enrich the method of Eurythmics. In this essay I examine how Swedish folk music and dance can enrich the Eurythmics method. Eurythmics is the starting point for the study and the paper contains a historical overview of Eurythmics, the development from the founder Jaques-Dalcroze to the teaching method of Eurytmics i

Injury prevention programmes can reduce injuries in youth team sports, including handball. However, real-world effectiveness and impact of such programmes are limited due to poor implementation. To address this in Swedish youth handball, the 'Implementing injury Prevention training ROutines in TEams and Clubs in youth Team handball' (I-PROTECT) programme was co-created with end-users, including co

Objectives: To assess the existence of international, scientifically validated methods for manual surgical skills training and assessment. The aim was to create a descriptive chronological summary of the existing evidence and conclusions in the included articles. Methods: PubMed and Scopus were searched twice for reviews published between 1997 and October 2023 and between 1997 and January 2024. Th

Nanowires are promising structures for next-generation photonic devices due to their superior structural, optical, and electronic properties compared to thin films. In this study, unexpected electrostatic potential wells across the non-polar m-plane and at the core/shell interface in n-type GaN core/shell nanowires, grown via metal-organic vapor phase epitaxy, are reported. Using advanced electron

Aims: This study compares the associations of Life's Simple 7 (LS7) and Life's Essential 8 (LE8) with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic (CKM) syndrome populations. Methods: This cohort study analyzed 11,487 participants aged ≥20 years with CKM syndrome from NHANES 2005–2018. Participants were categorized into non-advanced (stages 0–2) and advanced (stages 3–

Background: Dyspnea is a common and diagnostically challenging symptom in the emergency department (ED), particularly among older adults with multimorbidity. Traditional risk stratification tools often perform poorly in this population. Galectin-3 (Gal-3), a biomarker of inflammation and fibrosis, may reflect biological aging and resilience, potentially improving early mortality risk assessment.Ob

Susceptibility testing of clinical multidrug-resistant (MDR) and reference P. aeruginosa strains was performed using the standard twofold serial dilution method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antiseptics were determined. MIC and MBC values were also interpreted as the bacteriostatic index of antiseptic activity (BSIAA) and the bactericid

Fler än 800 000 svenskar har privata sjukvårdsförsäkringar, men effekten detta har på svensk sjukvård och jämlikhet går inte att följa i svenska register.

Aims Endotypes integrate individual clinical and molecular data and can be used to formulate molecular subclassifications of diseases. We previously derived four endotypes of subclinical carotid atherosclerosis in a large European cohort, c-IMT and c-IMT Progression as Predictors of Vascular Events in a High-Risk European Population (IMPROVE), identifying individuals with a specific cardiovascular

Background Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis. Still, little is known about the individual variation over time of the prothrombin concentration in plasma in the general population. Objectives This study aimed to establ

Introduction: The importance of measuring vascular age has been emphasized in numerous studies, highlighting its critical role in precision medicine. This cross-sectional heterogeneity exploration study examined sex- and country-specific association of serum uric acid (SUA) and inflammation, measured as high sensitivity C-reactive protein (hs-CRP), and vascular aging across populations with divers

Background: Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF). Research Question: What are the current practices for assessment of sleep and nocturnal hypoxemia in PF, and what are the research priorities and outcome measures of importance for nocturnal oxygen therapy (NOT)? Study Design and Methods: People with PF and health care professionals (HCPs) with expertise in PF, s

BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear.OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation.METHODS: Single-nucleotide polymorphisms (SNPs) signific

Introduction: Implementing new treatment regimens entails a learning phase with a concomitant risk of suboptimal results. High caseload has generally been shown to improve results in complex surgical procedures. This study aimed to evaluate results of Cytoreductive Surgery (CRS) and Intraperitoneal Chemotherapy (IP), given as Early Postoperative Intraperitoneal Chemotherapy (EPIC) or Hyperthermic

Objectives: To evaluate the test–retest reliability of a novel laboratory-based protocol for inducing and measuring head acceleration in multiple directions under anticipated and unanticipated conditions. Design: Laboratory-based test–retest reliability study. Methods: Thirty physically active adults (50% female) completed standardized head perturbations using a custom-built apparatus. Perturbatio