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Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. Novel treatment strategies are highly needed, as well as increased understanding of the hi

Ductus venosus blood flow velocity waveform in diabetic pregnancies

Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of

Predictors of Presenteeism and Activity Impairment Outside Work in Patients with Spondyloarthritis

Purposes To assess predictors of presenteeism (reduced productivity at work) and activity impairment outside work in patients with spondyloarthritis (SpA). Methods Multivariate logistic regression analysis was used to study predictors of presenteeism and activity impairment in 1,253 patients with SpA based on a 2.5 year follow-up questionnaire. The Work Productivity and Activity Impairment (WPAI)

Anterior Cruciate Ligament injury, Patient Variables, Outcomes and Knee Osteoarthritis

The ruptured anterior cruciate ligament (ACL) leads to immediate symptoms that severely affect the individual and receives great attention among the scientific community, yet there is still no consensus on the optional form of treatment. An ACL injury is also a well known high risk factor for the development of knee osteoarthritis (OA) some decades later. Knee OA development after an ACL injury is

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts

OBJECTIVE: To identify how the gp130-signaling cytokine oncostatin M (OSM), acting alone or in concert with IL-1beta or TNFalpha, affects synovial fibroblast expression of genes relevant to inflammation and bone erosion in inflammatory arthritis. METHODS: Synovial fibroblasts (SFs) were isolated from non-arthritic wild type (WT) or OSM receptor deficient (OSMR(-/-)) mice and stimulated with OSM, I

Intra-governmental coordination for sustainable disaster recovery: A case-study of the Eden District Municipality, South Africa

Post-disaster coordination is an essential aspect to achieve sustainable disaster recovery. However, to date, little attention has been paid to the subject of coordination in disaster recovery in comparison to response coordination. This study is an investigation into the factors affecting coordination for sustainable disaster recovery. It uses the case-study of Eden district Municipality in South

Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes

Airway epithelial injury is regarded as a key contributing factor to the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. The concentration of the pneumoprotein club cell (Clara cell) CC16 in urine has been found to be a non-invasive marker for hyperpnoea-induced airway epithelial perturbation. Exercise-hyperpnoea induces mechanical, thermal and osmotic stress to the airways

Population-based consultation patterns in patients with shoulder pain diagnoses

Background: To assess the annual consultation prevalence and new onset consultation rate for doctor-diagnosed shoulder pain conditions. Methods: We identified all residents in the southernmost county in Sweden who received a shoulder pain diagnosis during 2006 (ICD-10 code M75). In subjects who did not consult due to such disorders during 2004 and 2005, we estimated the new onset consultation rate

Secondary electron imaging of nanostructures using Extreme Ultra-Violet attosecond pulse trains and Infra-Red femtosecond pulses

Surface electron dynamics unfold at time and length scales down to attoseconds and nanometres, making direct imaging with extreme spatiotemporal resolution highly desirable. However, this has turned out to be a major challenge even with the advent of reliable attosecond light sources. In this paper, photoelectrons from Ag nanowires and nanoparticles excited by extreme ultraviolet (XUV) attosecond

Frequency Modulation in mm-Wave InGaAs MOSFET/RTD Wavelet Generators

Co-integration of an InGaAs MOSFET and an RTD is performed to realize a wavelet generator. The large transconductance of the MOSFET (1.9 mS/mu m) is used to switch the current in an oscillator circuit and coherent wavelets down to 41 ps are generated in the frequency domain of 50 to 100 GHz. The lowest power consumption measured is 1.9 pJ/pulse. It is found that the supply bias can be used to modu

Effects of crystal phase mixing on the electrical properties of InAs nanowires

We report a systematic study of the relationship between crystal quality and electrical properties of InAs nanowires grown by MOVPE and MBE, with crystal structure varying from wurtzite to zinc blende. We find that mixtures of these phases can exhibit up to 2 orders of magnitude higher resistivity than single-phase nanowires, with a temperature-activated transport mechanism. However, it is also fo

A third generation glucose biosensor based on cellobiose dehydrogenase from Corynascus thermophilus and single-walled carbon nanotubes.

A third generation glucose biosensor working under physiological conditions with a linear range of 0.1-30 mM, a detection limit of 0.05 mM, and a sensitivity of 222 nA microM(-1) cm(-2) has been developed by co-adsorption of cellobiose dehydrogenase (CDH) from the ascomycete Corynascus thermophilus (CtCDH) and oxidatively shortened single-walled carbon nanotubes (SWCNTs).

Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method ca

Are time-trends of smoking among pregnant immigrant women in Sweden determined by cultural or socioeconomic factors?

Background: The widening socioeconomic gap in smoking during pregnancy remains a challenge to the Swedish antenatal care services. However, the influence of cultural factors in explaining the socioeconomic differences in smoking during pregnancy is not clear among the immigrant women. The aim of this study was to investigate whether the development of smoking prevalence among pregnant immigrant wo

High-k dielectrics on (100) and (110) n-InAs: Physical and electrical characterizations

Two high-k dielectric materials (Al2O3 and HfO2) were deposited on n-type (100) and (110) InAs surface orientations to investigate physical properties of the oxide/semiconductor interfaces and the interface trap density (D-it). X-ray photoelectron spectroscopy analyses (XPS) for native oxides of (100) and (110) as-grown n-InAs epi wafers show an increase in As-oxide on the (100) surface and an inc

Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH

Background: Low blood levels of vitamin D (25-hydroxy D3, 25OHD3) in women have been associated with an increased risk of several diseases. A large part of the population may have suboptimal 25OHD3 levels but high-risk groups are not well known. The aim of the present study was to identify determinants for serum levels of 25OHD3 in women, i.e. factors such as lifestyle, menopausal status, diet and