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BACKGROUND: Pharmaceutical expenditures (PE) are increasing worldwide raising concerns about sustainability. However, the current price index provides an incomplete picture of this trend due to the rapid introduction of new drugs on the market.OBJECTIVE: The aim of this study is to decompose PE into their components and investigate the development in Sweden from 1990 to 2022.METHODS: The PE index

Background In adults with serious respiratory illness, fatigue is prevalent and under-recognised, with few treatment options. The aim of this review was to assess the impact of graded exercise therapy (GET) on fatigue in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials (RCTs) testing GET (involving incremental increases in

Haemolysis occurring during cardiac surgery with cardiopulmonary bypass (CPB) is assumed to be a risk factor for postoperative acute kidney injury (AKI). Plasma alpha-1 microglobulin (A1M) may have a protective role as haem scavenger. The aim of this study was to evaluate the association between AKI and the degree of haemolysis and the course of A1M concentrations during cardiac surgery, respectiv

The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMRCys) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy individu

Abstract NRWC 2024 Internal marketing in changing times - Supporting personnel meeting customers in physical retail storesUlf Johansson, Lund School of Economics and management, Center for retail studies at Lund universityKristina Bäckström, Campus Helsingborg, Lund university, Center for retail studies at Lund universityA lot has been written about the change of retail in later years (Berman, 201

Background: The Prostatype score (P-score) is a prognostic biomarker that integrates a three-gene (IGFBP3, F3, and VGLL3) signature derived from prostate biopsy samples, with key clinical parameters, including prostate-specific antigen (PSA) levels, Gleason grade, and tumor stage at diagnosis. The test has demonstrated superior predictive accuracy for prostate cancer outcomes compared with traditi

Background/Aim: An inverse association exists between type 2 diabetes mellitus (T2DM) and both plasma vitamin D levels and sun exposure, but vitamin D supplementation does not reduce the incidence. We sought to assess whether there is a dose-dependency in the association between sun exposure and T2DM. Patients and Methods: The melanoma in Southern Sweden (MISS) cohort is comprised of one thousand

Background/Objectives: Recent decades have witnessed a sharp increase in research investigating the association between hearing loss and cognitive impairment. Few previous studies have stratified for sex when investigating this issue, where results were inconsistent and require further clarification. Thus, the objective was to investigate the association between self-reported hearing loss and leve

This study analyzes the relationship of having a child with the early-onset disability cerebral palsy (CP) and the parental decision to divorce and to have additional children. We use longitudinal matched case-control data from multiple linked Swedish National Population Registers between 2001 and 2015 and perform Cox proportional hazards regressions with interval-censoring. Although we do not fin

In Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits ofIn Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits of

Purpose: The purpose of this case-control study was to investigate the associations between maternal serum concentrations of vitamin D early in pregnancy and the occurrence of preterm birth. Methods: The study included 269 women (cases) whose children were born preterm (< 37 gestational weeks [gw]) and 332 women (controls) whose children were born term (≥ 37 gw). Among the cases, 59 were extreme p

Purpose:The purpose is to identify factors influencing the environmental sustainability of e-commerce packaging across its lifecycle.Design/methodology/approach:A systematic literature review captured 45 articles. To categorise the literature, a conceptual framework based on a lifecycle perspective was developed. An actor perspective analysed their influence and responsibilities.Findings:Five fact

BACKGROUND: Local resection of early rectal cancer (RC) is a desirable treatment option compared with surgery, offering reduced morbidity, mortality, health care costs and avoidance of stoma. However, local resection is restricted to cases without suspicion of lymph node metastases (LNM). Current methods to diagnose LNM and risk estimations based on histopathology cannot reliably identify patients

Purpose Children living with respiratory support rely on medical technology, either fully or partially, throughout the day to meet their breathing requirements. Although children and young people living with respiratory support at home undergo long-term treatments and make extensive use of health and social care services, there is a notable absence of comprehensive outcome data on this group. The

OBJECTIVES: Loneliness and social isolation are major public health concerns that contribute to numerous health consequences. While many interventions effectively reduce loneliness and social isolation, their cost-effectiveness remain unclear. This study aimed to evaluate and consolidate evidence on the cost-effectiveness of interventions addressing loneliness or social isolation.METHODS: We condu

Background: Transanal endoscopic microsurgery (TEM) is only curative treatment for T1 rectal cancer with low-risk features. In T2 cancer, TEM is not recommended but could be used as a palliative procedure and/or in patients unfit for surgery. Few studies exist investigating recurrence after TEM for T2 rectal cancer. Method: Retrospective, population-based study using the Swedish Colorectal Cancer