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To clarify the structure of genetic risks for 11 major psychiatric disorders, we calculated, from morbidity risks for disorders in 1st–5th degree relatives controlling for cohabitation effects, in the Swedish population born between 1932 and 1995 (n = 5,830,014), the family genetic risk scores (FGRS) for major depression (MD), anxiety disorders (AD), obsessive-compulsive disorder (OCD), bipolar di

Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effec

BACKGROUND: Major depressive disorder (MDD) is one of the most common psychiatric disorders and is a great disease burden. However, its underlying pathophysiology and aetiology remain poorly understood. Available evidence suggests that circulating microRNAs (miRNAs) are associated with MDD, but it is still unknown whether miRNAs can predict subsequent incident MDD.METHODS: In this nested case-cont

Widowhood involves many practical challenges next to the emotional impact of bereavement. Remarriage to a blood relative of a deceased spouse can often help a bereaved spouse to solve issues related to inheritance, child care, and comfort in a stressful period. A study of 15,540 widowers and 18,837 widows in the Dutch province of Zeeland—of whom about 8,000 men and 5,000 women eventually remarried

Alexandra Kollontai was the Soviet ambassador to Sweden in the years1930 to 1945. In Sweden she gained many friends in the peace- and women’s movement and among these were several female physicians. This article describes and investigates the friendships between Swedish female physicians and Alexandra Kollontai. The three physicians focused on are Ada Nilsson (1872–1964), Andrea Andreen (1888–1972

We have previously demonstrated that we can grow p-type GaAs nanowires using Zn doping during gold catalyzed growth with aerotaxy. In this investigation, we show how to calculate the hole concentrations in such nanowires. We base the calculations on the Zhang–Northrup defect formation energy. Using density functional theory, we calculate the energy of the defect, a Zn atom on a Ga site, using a su

Crystal growth of semiconductor nanowires from a liquid droplet depends on the stability of this droplet's liquid-solid interface. Because of the assisting property of the droplet, growth will be hindered if the droplet is displaced onto the nanowire sidewalls. Using real-time observation of such growth by in situ transmission electron microscopy combined with theoretical analysis of the surface e

Silicide based compounds are widely used for coatings due to their high melting temperature, oxidation resistance and moderate density. Employment of binders based on silicides of transitional metals can provide cBN-based cutting tools with higher chemical stability and better performance. The relationship between phase composition, microstructure and mechanical properties of novel polycrystalline

Mammographic sensitivity in breasts with higher density has been questioned. Higher breast density is also linked to an increased risk for breast cancer. Even though digital breast tomosynthesis (DBT) offers an attractive solution, for varied reasons it has not yet been widely adopted in screening. An alternative could be to boost the performance of standard mammography by using computer-aided det

Most of field stars originate from dissolved star clusters. If the gas cloud is well mixed the stars in the cluster are expected to be chemically homogenous. Although the original kinematical information of a star may be lost under the Galactic dynamic evolution, the chemical signatures are preserved in the form of elemental abundances in individual low-mass stars. The present-day distribution of

Popular Abstract in English Life on earth has evolved countless forms, beautiful shapes and colors as well as astonishingly complex systems. Remarkably, all living creatures consist of cells, which themselves are build from the same basic set of molecules, most importantly nucleic acids (RNA and DNA), lipids and proteins. The latter are large macromolecules that fulfill a vast number of tasks; theThe three-dimensional structure of protein is encoded in its amino acid sequence. Modern structure prediction algorithms make it possible to predict the structure of small proteins using sequence information alone. We used the Fold-and-Dock algorithm, which is part of the Rosetta macromolecular modeling suite, for de novo structure prediction of coiled-coil proteins. Members of this protein family

The adsorption of 3-(triethoxysilyl)propionitrile (TESP) on a reduced rutile TiO2(110) surface has been investigated using synchrotron-based X-ray photoelectron spectroscopy in ultrahigh vacuum (UHV). We have studied TESP adsorption on two surface preparation of rutile TiO2 (110) to explore the role of surface defects. In the first preparation, the adsorption of TESP was studied on reduced TiO2 (1

Transmission electron microscopy (TEM) is a popular off-line technique to study aerosol nanoparticles. Coupled with an X-ray detector, high-resolution elemental maps of the sample can be obtained by scanning the focused electron beam and collecting the emitted X-ray spectra, called energy dispersive X-ray spectroscopy (EDX). Interpretation of the acquired data can be difficult in the case of compl