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Direct laser writing (DLW) has arise interest in a variety of fields due to the capabilities that we get from the realization of 2D and 3D structures with high resolution fabrication techniques. Multi-photon lithography (MPL) relies on non-linear absorption effects, making possible the fabrication of metasurfaces with feature size beyond the diffraction limit. A new approach in this direction is t
Single-cell technologies have transformed our understanding of cellular heterogeneity through multimodal data acquisition. However, robust cell alignment remains a major challenge for data integration and harmonization, including batch correction, label transfer, and multi-omics integration. Many existing methods constrain alignment based on rigid feature-wise distance metrics, limiting their abil
Hardware implementing spiking neural networks (SNNs) has the potential to provide transformative gains in energy efficiency and throughput for energy-restricted machine-learning tasks. This is enabled by large arrays of memristive synapse devices that can be realized by various emerging memory technologies. But in practice, the performance of such hardware is limited by non-ideal features of the m
Background: Antibiotics are commonly prescribed for outpatient management of cystitis. Previous evidence suggests that certain factors likely beyond the infection seem to influence the choice of antimicrobial treatment. However, studies on the specific antibiotic treatments for cystitis are lacking. This study aimed to explore the antibiotic treatments for cystitis using nationwide primary healthc
Health impact assessments (HIA) have largely focused on mortality; this report, therefore, examines and evaluates which morbidity impacts are appropriate to include in HIAs. The task was assigned by Swedish Environmental Protection Agency (EPA), and the original report (written in Swedish) was performed by Anna Oudin (AO), Erin Flanagan (EF), and Ebba Malmqvist (EM). The original report also inclu
The molecular sensitivity provided by optical photons has potential advantages in medical diagnostics, for example, in distinguishing healthy from cancerous tissue. However, scattering resulting from inhomogeneities in the refractive index of tissues prevents spatially resolved optical measurements in biological material, except at very shallow depths. This thesis presents research on a medical im
It is commonly accepted that exoplanets with orbital periods shorter than one day, also known as ultra-short-period (USP) planets, formed further out within their natal protoplanetary disks before migrating to their current-day orbits via dynamical interactions. One of the most accepted theories suggests a violent scenario involving high-eccentricity migration followed by tidal circularization. He
Vertically oriented graphene (VG) has attracted attention for years, but the growth mechanism is still not fully revealed. The electric field may play a role, but the direct evidence and exactly what role it plays remains unclear. Here, we conduct a systematic study and find that in plasma-enhanced chemical vapor deposition, the VG growth preferably occurs at spots where the local field is stronge
Introduction: A blood-based biomarker (BBBM) test could help to better stratify patients with traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary insults, predict outcomes, and monitor treatment effects and quality of care. Research question: What evidence is available for clinical applications of BBBMs in TBI and how to advance this field? Material and methods:
Introduction: Dementia is a condition (a collection of related signs and symptoms) that causes a continuing deterioration in cognitive function, and millions of people are impacted by dementia every year as the world population continues to rise. Conventional approaches for determining dementia rely primarily on clinical examinations, analyzing medical records, and administering cognitive and neur
Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for more specific subdivisions of the MTL in humans. In addition, recent studies suggest that early changes in many neurodegenerative and neuropsychiatric diseases are better detected in smaller subregions of the MTL rather than with whole stru
We introduce the concept photophysical image analysis (PIA) and an associated pipeline for unsupervised probabilistic image thresholding for images recorded by electron-multiplying charge-coupled device (EMCCD) cameras. We base our approach on a closed-form analytic expression for the characteristic function (Fourier-transform of the probability mass function) for the image counts recorded in an E
Music therapy is a “vocally demanding profession” [1, p. 46]. Currently, little is known about the prevalence and about the possible risk factors for voice disorders within music therapy. As music therapy workspaces may not always be ideal in terms of acoustics, the aim of the study is to investigate room acoustics and noise as risk factors for possible voice disorders among music therapists in Fi
We present a high-repetition rate, atttosecond light source, emitting controlled short trains of attosecond pulses. We apply this source to the study of photoionization of atoms using a 3D photoelectron/ion coincidence spectrometer.
Children with cancer experience fragmented school attendance during treatment. Telepresence robots that connect them with school during treatment periods were explored through an intervention involving participant observation followed by semi-structured interviews from 2020–22 with children with cancer, their class teachers, and classmates. We used an abductive approach, inspired by the Agential R
Activating Notch1 mutations have been reported in human T-line-age acute lymphoblastic leukemia (T-ALL) and lymphomas from genetically modified mice. We report that Notch1 is a prevalent and major mutational target in chemically induced mouse lymphoma. The regions of the gene that are frequently mutated are the heterodimerization domain and the N-terminal ligand-binding region, important for prote
OBJECTIVE: To quantify the risks of mortality, morbidity and postnatal characteristics associated with extreme preterm fetal growth restriction (EP-FGR).DESIGN: The EVERREST (Do e s v ascular endothelial growth factor gene therapy saf e ly imp r ove outcome in seve r e e arly-onset fetal growth re st riction?) prospective multicentre study of women diagnosed with EP-FGR (singleton, estimated fetal
Background Despite a large descriptive literature linking creativity and risk for psychiatric illness, the magnitude and specificity of this relationship remain controversial. Methods We examined, in 1 137 354 native Swedes with one of 59 3-digit official and objective occupational codes in managerial and educated classes, their familial genetic risk score (FGRS) for ten major disorders, calculate
In this paper, we argue that information researchers should use images as a source of data. The information systems field is overwhelmingly visual in nature. Not only is the Internet crammed with images, but also almost every detail observed during fieldwork in different research settings can be captured in the form of digital images. Yet, we rarely engage with those images. Except for sporadic vi
