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Sperm DNA fragmentation index (DFI) assessed by sperm chromatin structure assay is a valuable tool for prediction of fertility in vivo. Previous studies on DFI as predictor of in vitro fertilization (IVF) outcome, based on relatively small materials, gave contradictory results. The present study examines, in a large cohort, the association between sperm DFI and the outcome of IVF/ICSI procedure. T
To date, the assessment of hydrological climate change impacts, not least on pluvial flooding, has been severely limited by i) the insufficient spatial resolution of regional climate models (RCMs) as well as ii) the simplified description of key processes, e.g., convective rainfall generation. Therefore, expectations have been high on the recent generation of high-resolution convection-permitting
Non-alcoholic steatohepatitis (NASH), one of the deleterious stages of non-alcoholic fatty liver disease, remains a significant cause of liver-related morbidity and mortality worldwide. In the current work, we used an exploratory data analysis to investigate time-dependent cellular and mitochondrial effects of different supra-physiological fatty acids (FA) overload strategies, in the presence or a
Background The number and rank order of siblings could be of importance for risk of cardiovascular disease and mortality. Previous studies have used only fatal events for risk prediction. We, therefore, aimed to use also non-fatal coronary and cardiovascular events in fully adjusted models. Methods From the Multiple-Generation Register in Sweden, data were used from 1.36 million men and 1.32 milli
The pharmacologic and pharmacokinetic properties were evaluated in a series of antiuterotonic oxytocin analogs, modified at positions 1, 2, 4, 8 and, in one case, position 9 of the oxytocin (OT) molecule. [Mpa1,D-Tyr2(Et),Val4,Orn8,desGly9]-OT, [Mpa1,Tyr2(Et),Val4,Orn8]-OT and [Mpa1,D-Tyr2,Val4,Orn8]-OT displayed similar plasma clearance rates (Clps) using the constant infusion method in rats. Two
INTRODUCTION: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior
A search is presented for the production of a single top quark via left-handed flavour-changing neutral-current (FCNC) interactions of a top quark, a gluon and an up or charm quark. Two production processes are considered: u+ g→ t and c+ g→ t. The analysis is based on proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. The data set correspond
High dust density in the midplane of protoplanetary disks is favorable for efficient grain growth and can allow fast formation of planetesimals and planets, before disks dissipate. Vertical settling and dust trapping in pressure maxima are two mechanisms allowing dust to concentrate in geometrically thin and high-density regions. In this work, we aim to study these mechanisms in the highly incline
Background: Norm values for patient reported outcomes, that is knowledge about how the general population of women rate their breast-related satisfaction and quality of life, are necessary to interpret the meaning of scores. The aims of this study were to create Swedish normative values for the BREAST-Q reduction/mastopexy module and to describe what healthy women are most satisfied/dissatisfied w
In higher plants, genes for subunits of respiratory chain complex I (NADH:ubiquinone oxidoreductase) have so far been identified solely in organellar genomes. At least nine subunits are encoded by the mitochondrial DNA and 11 homologues by the plastid DNA. One of the 'key' components of complex I is the subunit binding the substrate NADH. The corresponding gene for the mitochondrial subunit has no
Recently several distinct literatures have thematically converged around the topic of non-European state-making: political scientists – both comparativists and international relations scholars, historical sociologists, comparative and world historians, anthropologists, archaeologists and others, have begun to interest themselves in state making or state formation in non-European settings, and also
This study was undertaken to evaluate the role of internalization in the action of the peptide autacoid bradykinin (BK). At 4°C [3H]BK binds to an apparently single class of B2 kinin receptors on DDT1 MF-2 smooth muscle cells (C. M. Munoz, S. Cotecchia, and L. M. F. Leeb-Lundberg, manuscript submitted). At this temperature the [3H]BK binding was confined exclusively to the cell surface. On the oth
The built environment accounts for approximately 32 % of the global final energy use but also holds great potential for energy efficiency still to be harnessed (Lucon et al., 2014). To develop innovative policies for energy efficiency that are capable of realizing transformative changes, we argue that there is an urgent need for new systemic evaluation frameworks that provide learning and knowledg
Cognitive behavioral therapy (CBT) is an efficacious therapy for youth anxiety disorders. Caregivers are key stakeholders in youth therapy, and their feedback on treatment can help to inform intervention personalization. This mixed-methods study applied a systematic inductive thematic analysis to identify themes among most- and least-liked CBT features reported by caregivers using open-ended respo
Purpose: A new biodegradable liquid fiducial marker was devised to allow for easy insertion in lung tumors using thin needles. The purpose of this study was to evaluate the visibility of the liquid fiducial markers for image-guided radiation therapy and compare to existing solid fiducial markers and to one existing liquid fiducial marker currently commercially available. Methods: Fiducial marker v
Purpose: To assess the risk of recurrent venous thromboembolism (VTE) and death in patients with unreported cancer-associated incidental pulmonary embolism (iPE). Materials and methods: Matched cohort study on cancer patients with a CT study including the chest between 2014-01-01 and 2019-06-30. Studies were reviewed for unreported iPE, and cases were matched with controls without iPE. Cases and c
The objective of this paper is twofold. First, against the background of an existing empirical literature on the duration of trade which has found that international trade is often of strikingly short duration, we aim to establish whether or not EU imports from the rest of the world also are short-lived. Second, since there is at this point no clear commonly accepted theoretical explanation for th
The extent of behavioral recovery following neural transplantation in part depends on the amount of surviving graft tissue. The main objective of this thesis was to study parameters affecting the survival of embryonic striatal and mesencephalic neurons in experimental models of Huntington's and Parkinson's disease. Firstly, we studied the survival and maturation of embryonic striatal neurons that
Recent research on the Book of Psalms has been dealing intensively with issues relating to its so called “final shape." Proceeding from, among others, an influential dissertation by Gerald H Wilson, scholars have argued that the collection, as it now stands, is “more than the sum of its parts” (so e.g. McCann). Although such a notion is fairly straight forward on a conceptual or general level, it
In the wake of alarming reports from IPCC, policy makers all over the world have recognized offshore wind power to become an essential contributor in the future renewable energy system and battling of climate change. However, many countries including Norway lack extensive areas of shallow water suitable for conventional offshore wind, hence an interest for deep offshore solutions has arisen. One o
