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Background: Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating longitudinal outcomes over an extended period of time are limited. Therefore, we aimed to investigate clinical outcomes up to 9 years after amyloid-PET to support the clinical validity of the imaging technique. Methods: We analyzed longitud

The widely accepted “Milankovitch theory” explains insolation-induced waxing and waning of the ice sheets and their effect on the global climate on orbital timescales. In the past half century, however, the theory has often come under scrutiny, especially regarding its “100-ka problem.” Another drawback, but the one that has received less attention, is the “monsoon problem,” which pertains to the

Molecular subtypes of urothelial carcinoma may be divided into luminal and nonluminal tumors. Nonluminal tumors are composed of cases with basal/squamous-like or small cell/neuroendocrine features, with a consensus on the molecular characteristics of the respective subtype. In contrast, luminal tumors are more disparate with three to five suggested subtypes and with definitions that do not always

BACKGROUND: Many lifestyle factors have been associated with the metabolic syndrome (MetS). However, most of these studies have not considered the potential impact of obesity and have often only investigated one lifestyle factor at the time. We aimed to investigate the interplay between body mass index (BMI) and MetS with respect to multiple lifestyle factors.METHODS: BMI and MetS [National Choles

This volume originally started as a conversation between academics from across the Arab world, all of whom have bridged their academic careers or professional development expertise to the public sphere in order to use their knowledge more actively to push for progressive, democratic change in their respective countries. Over the course of the conversation, Arab engaged scholars and activists share

This study aimed examin the factors associated with the uptake and non-acceptance of COVID-19 vaccine booster doses among healthcare workers (HCWs) in South Africa. We used a mixed-methods design with data from a web-based self-administered survey followed by semi-structured in-depth interviews (IDIs) with selected participants. Of the 6235 HCWs included in our analysis who had fully vaccinated, 3

We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intensive care unit between January 1, 2018, and June 30, 2022. A. baumannii-infected patients in the intensive car

Cerebral palsy (CP) comprises a heterogeneous group of conditions recognized by disturbances of movement and posture and is caused by a non-progressive injury to the developing brain. Birth prevalence of CP is about 2-2.5 per 1,000 live births. Although the motor impairment is the hallmark of the diagnosis, individuals with CP often have other impairments, including cognitive ones. Cognitive impai

Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study. Methods: Targeted mass spectrometry metabolomics

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual M

BACKGROUND: Central venous catheter (CVC) misplacement occurs frequently after right subclavian vein catheterization. It can be avoided by using ultrasound to confirm correct guidewire tip position in the lower superior vena cava prior to CVC insertion. However, retraction of the guidewire during the CVC insertion may dislocate the guidewire tip from its desired and confirmed position, thereby res

This thesis is an exploration of leadership dimensions of academic organisational processes. It consists of four case studies, each presenting a leadership challenge. These studies of specific situations offer great opportunities to investigate the variety of leading that the academy contains. There is focus, not so much on the task but on the process in which the challenges are positioned, how th

The purpose of this booklet is to offer easy-to-use guidelines for businesses to design and implement circularity strategies into their business model. Specifically, the booklet will provide step-by-step guidance on how to ideate, design, test, and scale novel circular business models. For each stage of this circular business model innovation (CBMI) process a selection of tools and methods will be

This paper deals with new forms of political mobilisation and participation in social media, such as blogs, social network sites and the likes. The main focus is on the impor-tance of social networks in providing a “media filter”, functioning as a kind of collective gatekeeper to spread news and information perceived as important, in contrast to the image of the single individual media consumer fa

The number of meanings that can be found in the dictionary entries of the verb SEE in various languages ranges from 9 to 30:1. Language No of meanings Vision Mental process Lithuanian 20 + + English 28-30 + + Swedish 4-5 (15) + + Russian 9 + + On a closer look at the definitions of the meanings and the examples given we shall see that they fall into two basic types of meaning, namely (a) those th

The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms of the variance of apparent diffusivities within a voxel. However, the link between the diffusional variance and the tissue heterogeneity is not well-established. To investigate this link we test the hypothesis that diffusional variance, caused by microscopic anisotropy and isotropic heterogeneity, is assoc

Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materi

En av den svenska regeringsmaktens minst uppmärksammade och sällan omdiskuterade maktbefogenheter är regeringens rätt enligt 12 kap. 9 § första stycket regeringsformen att genom nåd efterge eller mildra en brottspåföljd eller annan sådan rättsverkan av brott samt ett annat liknande myndighetsingrepp som avser enskildas person eller egendom. Nådeinsti-tutet innebär att regeringen, under ett politisOne of the least noticed and rarely discussed powers of the Swedish gov-ernment is its right according to chapter 12. Section 9, first sentence, in the Instrument of Government to pardon or mitigate a criminal penalty or oth-er such legal effect of a crime as well as another similar intervention by authorities that concerns the person or property of individuals. The right to pardon means that the

There is a strong need to replace animal-based experiments with in vitro alternatives. Mutz-3, a myeloid cell line, has been successfully used to investigate skin sensitization. A problem with in vitro assays, not only affecting Mutz-3, is the use of Fetal Bovine Serum for cell cultivation, as it is a serum supplement which is not fully defined, and it introduces variability in cell-based experime

Uppsatsen har genom en rättssociologisk undersökning granskat hur en lagändring gällande barnets behov av en god och nära kontakt med båda föräldrarna förhåller sig till barnets välmående i alla vårdnads-, boende -och umgängesmål. Lagändringen framförs i proposition 2024/25:10 tryggare hem för barn, som uppsatsen har redovisat för samt i betänkandet till propositionen. Lagändringen motiveras av enThe thesis has examined how a legislative change regarding the child's need of a good and close relationship with both parents relates to the child's well-being in all custody, residence, and contact matters. The legislative change is presented in the bill 2024/25:10 A Safer Home for Children, which the thesis has discussed, as well as the report accompanying the bill. The change is motiva