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Inactivation of the Ink4 gene locus locus on 9p comprising the tumour suppressor gene p16ink4a and its neighbours p14ARF and p15ink4b is common in childhood acute lymphoblastic leukaemia (ALL), but the prognostic significance is controversial. DNA from 230 patients was retrospectively analysed by Southern blotting, single strand conformation polymorphism (SSCP) and sequencing techniques. The resul
Severe protein C deficiency is a rare, early onset, venous thrombotic condition that is inherited as an autosomal recessive trait. The protein C (PROC) genes of nine unrelated individuals with severe protein C deficiency were sequenced yielding a total of 13 different lesions. Eight of these were novel, including a gross gene deletion, three missense mutations, two micro-deletions, a splicing muta
Accurate and internationally comparable human papillomavirus (HPV) DNA genotyping is essential for HPV vaccine research and for HPV surveillance. The HPV Laboratory Network (LabNet) has designed international proficiency studies that can be issued regularly and in a reproducible manner. The 2011 HPV genotyping proficiency panel contained 43 coded samples composed of purified plasmids of 16 HPV typ
Hereditary myopathy with early respiratory failure and extensive myofibrillar lesions has been described in sporadic and familial cases and linked to various chromosomal regions. The mutated gene is unknown in most cases. We studied eight individuals, from three apparently unrelated families, with clinical and pathological features of hereditary myopathy with early respiratory failure. The investi
Popular Abstract in Swedish Modelleringsarbetet utvecklat i denna avhandling, kan delas in i två huvudområden: självantändning i ottomotorer, samt förbränning och emissioner i dieselmotorer. En första version av ett motorsimuleringsprogram med detaljerad kemisk kinetik, utökad för att innefatta full-cykel beräkningar, användes för att visa den starka påverkan som kväveoxider i restgaser har på sjThe modeling work developed in this thesis can be divided in two main areas of investigations: autoignition related to spark ignition engine and combustion and emissions formation in relation to diesel engines. A first version of a detailed kinetics engine simulation program, extended to handle full cycle calculations, was employed in order to demonstrate the strong effect that nitric oxide from
In this paper we have conducted a systematic study of the photoelectron diffraction (PED) effects from the 3C-SiC(0 0 1)-c(4 x 2) surface by means of multiple-scattering calculations. Two models have been proposed to describe this surface: alternately up and down dimers (AUDD) [P. Soukiassian, F. Semond, L. Douillard, A. Mayne, G. Djuradin, L. Pizzagalli, C. Joachim, Phys. Rev. Lett. 78 (1997) 907
Popular Abstract in Swedish Sophia Elisabeth Brenner (1659-1730) var Sveriges första stora kvinnliga poet. Hon var verksam som författare och lärd kvinna under femtio år, och var dessutom en flitig brevskrivare. Avhandlingen baseras på en inventering av bevarade brev till och från Sophia Brenner skrivna på latin, svenska, franska och italienska. Hennes nylatinska korrespondens med danske Otto SpeSophia Elisabeth Brenner (1659-1730) was Sweden's first great female poet, writing and publishing her poems over a period of fifty years. She was also, however, a prolific letter writer. The dissertation is based on an inventory of all the preserved letters to and from her written in Latin, Swedish, French and Italian. Her Neo-Latin correspondence with the Dane Otto Sperling the Younger is presen
A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) in 2001. The assessment included an overview of the capacity for radiotherapy in terms of infrastructure of cancer care and an estimation of the costs of radiotherapy in Sweden. A postal questionnaire distributed to all 16 centres of radiotherapy in Sweden showed th
Popular Abstract in Swedish Svensk populärvetenskaplig sammanfattning Kvartärtidens avlagringar döljer mycket och detaljerad information om palaeoklimatet och de lämpar sig därför väl för att modellera palaeoklimatets förändringar. Inlandsisar är av avgörande betydelse för klimatet under kvartärtiden. Deras tillväxt och avsmältning beror till stor del på klimatiska faktorer, såsom temperatur, nedeThis thesis presents results from studies on geomorphology, lithostratigraphy and ice flow patterns during the final termination and deglaciation of the last Scandinavian Ice Sheet in NE Germany. Ice flow patterns derived from till fabrics and glaciotectonical data indicate that short-lived marginal domes had formed during the advance and the retreat of the last Scandinavian Ice Sheet in NE German
There is a growing interest on Open Source Enterprise Resource Planning (OS-ERP) systems among organizations today. When developing ERP systems a major problem is requirements management. Proponents of open source development often claim it has a high level of involvement from users in adopting organizations. However, comparing with proprietary ERP development it is not that clear if users are mor
Aim: This study aims at exploring how persons with hearing impairments, using cochlear implants, create and negotiate meaning in relation to soundscapes in modern society. Methods: Participants were contacted through national organisations for persons with hearing impairments. Data was gathered by means of a combination of interviews and an ethnological questionnaire. Results: For persons with coc
The impact of European Union law on the regional and local levels in the Member States has been underestimated for a long time now. Today, however, it is clear that the impact of European Union law on these levels is important, not least as a consequence of the deregulation that has been carried out in most Member States in recent years. As local markets open up for competition, the scope of EU la
Popular Abstract in Swedish I en tid då allt färre lever på landsbygden har jordbrukslandskapet blivit föremål för ett växande intresse. Landsbygdens landskap har i vår tid kommit att framstå som idylliskt, äkta och naturligt, men också som i hög grad hotat. Den här avhandlingen analyserar ur ett etnologiskt perspektiv vad landskap är och hur landskap skapas. Den behandlar bland annat människors oThe complex character of rural landscapes implies a constant interaction between mind and matter as well as between nature and society. In landscapes, the established division of reality into nature and culture appears all but natural. This book points to the possibilities of regarding landscape as a dialectical process. Landscape is here used as an analytical device to examine nature-culture rela
Popular Abstract in Swedish Öbiogeografi och populationsdifferentiering hos Skyros murödla Hur den fantastiska variationen som finns i naturen bildas är en fråga som länge fascinerat biologer. För mer än 150 år sedan inledde två välkända biologer, Charles Darwin och Alfred Russel Wallace, en brevväxling som skulle komma att bli startskottet för ett paradigmskifte. De hade båda fått idén om naturlIslands are cradles for new biodiversity and provide natural laboratories for the study of population divergence. In my thesis, I investigated the role of different evolutionary processes in the population divergence in the Skyros wall lizard (Podarcis gaigeae), a species where islet populations have strongly diverged morphologies. I used replicate islet populations and their respective most proxi
The major challenge in the development of new polymer membranes for fuel cells lies currently in the demand for durable membranes that allows fuel cell operation at high temperatures without extensive humidification requirements. Access to these membranes promises important benefits concerning the complexity, cost and performance of the fuel cell system. In this context, membranes functionalized w
Popular Abstract in Swedish Avhandlingen tar sin utgångspunkt i frågan om huruvida medeltidens kyrkomålningar kan berätta, och i så fall hur. Syftet är att utforska bildernas förhållande till texter, till betraktaren och det rum där bilderna och betraktaren befinner sig. Till grund för studiet ligger en inventering av medeltida kalkmålningar av Sankt Kristoffer och scener kring Jesu födelse ca 110The subject of the thesis is the narratives in medieval mural paintings in southern Scandinavia c 1100-1530. Its aim is to examine their relationship to texts, to the viewer and to the church space, where the viewer looks at the murals. Two different subjects have been chosen for study: S Christopher and the Nativity of Christ. From the corpus of preserved mural paintings with these subjects in so
The differentiation between expression and content is fundamental in the concept of signs. Even if the notions of signs are often revised, due partly to the attraction of a semiotic approach from markedly disparate objects of study, a common apprehension of the distinctive character of meanings by sign is its dual nature. (Saussure 1968, Piaget 1951, 1966; Vygotsky 1999; Sigel 1978; DeLoache 2000)
To analyze complex and noncomplex cardiac malformations regarding prevalence and in relation to demographic variables, we pooled data on infants (age I year or younger) with congenital cardiovascular defects from three large birth defect registries in California, Sweden, and France. Altogether. 12.932 infants had one or more congenital heart defects out of 4.4 million live births and stillbirths.
