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Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information. Treatment decisions in these cases rely on biomarker assessments and subtyping from tissue acquired through core needle biopsies. Tumor heterogeneity and representativity are pit-falls when limited tissue is available. Biomarker expression may change conside
Objectives To study the association between lifestyle risk factors and chronic hypertension by history of hypertensive disorders of pregnancy (HDP: gestational hypertension and pre-eclampsia) and investigate the extent to which these risk factors modify the association between HDP and chronic hypertension. Design Prospective cohort study. Setting Nurses' Health Study II (1991-2013). Participants 5
Background and Purpose: The EFFECTS (Efficacy of Fluoxetine - a Randomised Controlled Trial in Stroke) recently reported that 20 mg fluoxetine once daily for 6 months after acute stroke did not improve functional outcome but reduced depression and increased fractures and hyponatremia at 6 months. The purpose of this predefined secondary analysis was to identify if any effects of fluoxetine were ma
Popular Abstract in Swedish Syftet med den aktuella forskningen är att ge en bättre förståelse av förmaksflimmer, den vanligaste rytmrubbningen i hjärtat som drabbar så många som var tionde över 70 år. Mekanismerna för förmaksflimmer är långt ifrån kartlagda, vilket bland annat leder till att behandlingen är standardiserad istället för att den beror på de mekanismer som styr varje enskild patientsThis doctoral thesis is in the field of biomedical signal processing with focus on methods for the analysis of atrial fibrillation (AF). Paper I of the present thesis addresses the challenge of extracting spatial properties of AF from body surface signals. Different parameters are extracted to estimate the preferred direction of atrial activation and the complexity of the atrial activation pattern
BACKGROUND: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be invol
Ultrasonic motors (USMs) have been extensively studied for three decades, due to their attractive features, such as high torque at low speed, simple structure, and precise positioning capability. However, since USMs are driven by the friction force between the rotor and the stator in most cases, they inherently possess the friction loss and the wear of contact materials, which cause their low effi
Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functiona
BACKGROUND: Periampullary cancer is a term for cancers arising in or in close proximity to the pancreas. Pancreatic cancer is the 3rd leading cause of cancer death for both sexes and while surgery is the only option for cure, chemotherapy is given in both the adjuvant and palliative settings. The aim of this study was to investigate any sex and gender differences in patients with pancreatic and ot
Objectives To investigate the prevalence of axial spondyloarthritis (axSpA) in patients with chronic back pain (CBP) of less than 2 years (2y) duration referred to the rheumatologist, the development of diagnosis over time, and patient characteristics of those developing definite (d-)axSpA over 2y. Methods We analysed the 2y data from SPondyloArthritis Caught Early, a European cohort of patients (
The aim of this study is to evaluate the soft tissue response of the pure and Au-embedded PPg-PEG. PP-g-PEG2000, PP-g-PEG4000, Au-PP-g-PEG2000, and AuPP-g-PEG4000 were obtained via chlorination of polypropylene and polyethylene glycol in the presence of a base with a "grafting onto" technique. Solvent cast films of these four copolymers with PP as a control group were embedded into five different
Den tilltalades tidigare brottslighet kan i svensk rätt påverka påföljdsbestämningen för ny brottslighet, dvs. straffmätning och påföljdsval, på främst tre sätt. I första hand kan den tidigare brottsligheten beaktas genom ett skärpt påföljdsval. I andra hand har rätten möjlighet att förklara villkorligt medgiven frihet förverkad. I sista hand finns det genom straffskärpning möjlighet att förlänga
The archaeological traditions of the Viking Age have a complex history. Some of it has been nationalist in orientation, at times constructing proud historical narratives reflecting ownership in and continuity of the past. These narratives conflict with increasing population diversity in the Scandinavian nations, where contemporary identity politics grapple with real and imagined realities of im
Den 16 april 2026 presenterades det nya lagförslaget gällande skärpta regler för unga lagöverträdare i proposition 2025/26:246. I propositionen föreslås bland annat en partiell sänkning av straffbarhetsåldern till 13 år vid allvarlig brottslighet samt införande av ungdomsfängelse för åldersgruppen 13–14 år. Syftet med denna uppsats är att granska argumenten bakom förslaget och hur det förhåller On April 16th, 2026, the new legislative Government bill 2025/25:246 regarding stricter rules for young offenders was presented. The bill proposes a partial lowering of the age of criminal responsibility to 13 for severe crimes, and the introduction of youth imprisonment for the 13–14 age group. The purpose of this thesis is to examine the arguments behind the proposal and compare them with prev
With climate change causing more intense rainfall events and prolonged droughts, freshwa-ter resources are increasingly under pressure worldwide, including in regions such as Sweden where water scarcity was previously unexpected. While water conservation can reduce de-mand to some extent, long-term water security requires alternative and resilient water sources. Wastewater represents a reliable so
Public diplomacy, public relations, propaganda, and strategic narratives are all under the ‘umbrella’ of soft-power and nowadays’ international relations. Strategic narratives currently represent one of the most essential tools that political actors use to increase their influence on local and foreign audiences, gain public support, and lastly achieve their foreign policy objectives. This disser
I mars 2019 röstade EU-parlamentet igenom Direktivet om upphovsrätt på den digitala inre marknaden (”DSM-direktivet”) som medför förändringar i ansvarsstrukturen för upphovsrättsliga intrång på nätet. Direktivets kanske mest kontroversiella artikel är art 17 som behandlar ansvar för särskilda internetplattformar, så kallade ”onlineleverantörer av delningstjänster för innehåll” (”onlineleverantörerIn March 2019, the European Parliament adopted the Directive on Copyright in the Digital Single Market ("the DSM Directive") which implies changes in the liability regime of online copyright infringements. Perhaps the most controversial article in the directive is Art 17, which regulates liability on specific internet platforms, so-called "online content-sharing service providers” (
There were around one million apartments built in Sweden during 1965 to 1974 as part of the so called Swedish Million Programme, almost half of them concentrated in Stockholm, Gothenburg and Malmoe. These building are now considered unattractive. The need of renovation is urgent in many aspects -ventilation, windows, balconies, facades and sanitary pipe replacement. The total investment cost for t
