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Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR) expression. Targeting proteins that are expressed as a down-stream effect of AR activity is a promising rationale for management of this disease. The hum
A great variety of two-dimensional (2D) boron allotropes (borophenes) were extensively studied in the past decade in the quest for graphene-like materials with potential for advanced technological applications. Among them, the 2D honeycomb boron is of specific interest as a structural analogue of graphene. Recently it has been synthesized on the Al(111) substrate; however it remains unknown to wha
Today’s smart city agendas are the latest iteration of urban sociotechnical innovation. Their aim is to use information and communication technologies (ICT) to improve the economic and environmental performance of cities while hopefully providing a better quality of life for residents. Urban planners have a long-standing tradition of aligning technological in- novation with the built environment a
It is essential for superalloys (e.g., Inconel 718) to obtain an anticipated surface integrity after machining, especially for safety critical areas (e.g., aerospace). As one of the main characteristics for cutting tools, the rake angle has been recognized as a key factor that can significantly influence the machining process. Although there are large research interests and outcomes in the machini
Generally, three functions are assigned to the sense of smell, namely warning of potential danger, social communication, and importance for eating and drinking. These functions are also reflected in some of the complaints of patients with smell disorders: occurrence of household accidents, inability to smell other people like family members, loss of flavor perception. Still, approximately 5% of th
We integrate dualistic conceptions of the real with Peirce's perspectivesabout reality and abduction, emphasizing the concept of reason underlyingPeirce's thoughts. Peirce's abduction is related to the notions of retrogression and grounding in Hegel, later re-encountered in Hansonian-abduction. Abduction in turn is considered in relation to abstraction acquiring its fullest sense as a stage in the
This chapter introduces US author, journalist, blogger, and futurist Bruce Sterling. Since his science fiction (sf) debut with the story “Man-Made Self” (1976), Bruce Sterling has so far published eleven novels (plus one in collaboration with William Gibson), over 70 pieces of short fiction (not including dozens of collaborations), and a handful of chapbooks in various media, accruing a number of
Denna artikel innehåller en analys av samtliga rapporter från Statens offentliga utredningar (SOU), 1945-89. Analysen applicerar metoder inom digital humaniora och inkluderar forskning gjort i en Jupyterlabbmiljö som utvecklats på Humlab på Umeå universitet. Artikeln är ett resultat av forskningsprojektet Välfärdsstaten analyserad, som ämnar att digitalisera litteratur, arbetar med datasäkring av In 2015 the National Library of Sweden finished digitising all Governmental Official Reports (SOU) from 1922 to 1999. Traditionally, SOU reports – and work performed within different governmental committees – were tasked with preparing the Swedish government for apt and rational decision-making. The range of subjects covered by governmental committees and SOU reports basically includes every area
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and push
Today, Sweden has one of the highest female labour force participation rates in the developed world, but how deep are the roots of women’s involvement in gainful employment? In this article, I present new estimates of women’s labour force participation rate between 1870 and 1960, the time when the country shifted from a predominantly agrarian economy to an industrial and services-based society. Th
Cooperative breeding allows the costs of parental care to be shared, but as groups become larger, such benefits often decline as competition increases and group cohesion breaks down. The counteracting forces of cooperation and competition are predicted to select for an optimal group size, but variation in groups is ubiquitous across cooperative breeding animals. Here, we experimentally test if gro
Corruption has become, without a doubt, a buzzword in both academic and policy debates over the last three decades. The initial view that “corruption greases the wheels of economic growth” in the newly independent states of Africa and Asia has lost its validity in light of the current and ever-growing global coalition against corruption, spearheaded by Transparency International (TI) and the World
The scale of movement associated with the migration of many intra-African bird species is still poorly known even with the increasing availability of tracking devices. In this study, we tracked the movements of Black Coucals Centropus grillii breeding in Nigeria from late July using satellite telemetry. Individuals remained on the breeding site for several months; two individuals transmitted after
This study is concerned with how contemporary Belfast riots are represented in digital culture, with a specific focus on how social resilience is discursively cultivated (or hindered) through memes about said political violence.While a substantial amount has already been written about everyday practices in post-conflict Belfast, less is known about how digital narratives represent and make sense o
One of my research questions is how ludo-immersive opera can be understood and interpreted. Reich of Ran was conceived as an etude of how to design comprehensible rules for playing visitors. This developed into a turn-based ’micro opera’ with forked paths. Each visitor got to experience the opera alone with the opera character (played by me) and a live-electronic musician. Thus, there could be no
In the interpretation of treaties, according to Article 31 of the 1969 Vienna Convention, interpreters shall pay primary regard to conventional language and to "relevant rules of international law applicable in the relations between the parties". Applying this provision, it is obvious that interpreters will sometimes face questions of an inter-temporal nature. What law or what language should be b
Environmental policy is shifting the focus from production processes to product-related issues. The provision and use of environmental information is generally considered an essential element in addressing the environmental impacts associated with the life cycle of products. Environmental product declarations (EPD) are one of the much promoted informative instruments. A wide range of self-declarat
The purpose of this study is to gain a deeper understanding of how HR professionals experience digital HR platforms and how digitalization has influenced and transformed HR work, with particular focus on its social dimensions. The study is based on a qualitative research design and draws on semi-structured interviews with HR professionals in the private sector. The findings show that digitalizatio
Bird collisions with overhead power lines can cause power outages and raise ecological concerns. This thesis analyses bird-related power disruptions in E.ON Energidistribution AB’s Swedish power grid during the period 2009–2025. The aims are to analyse the impact of bird-related outages relative to other causes and to evaluate whether bird diverters reduce such disruptions. The study is based on d
Det svenska Lagrådet har uppgiften att granska lagar under lagstiftningsarbetet. Det bildades 1909 eftersom Högsta domstolen, som tidigare hade denna roll, var överbelastat av alla de nya lagar som skapades. Under det dryga sekel som det svenska Lagrådet har existerat så har det skett ett antal förändringar. Denna uppsats analyserar vilka förändringar som har skett och varför. Den jämför även detThe Swedish legal council is responsible for legal preview in the Swedish process for creating new laws. It was created 1909 because the supreme court, which was previously responsible for legal preview, was overrun by the amount of new laws. During the roughly one hundred years that the legal council has existed, a number of changes have been made. This essay analyses which changes have come to
