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Collagenase injection for Dupuytren's contracture is commonly administered without anesthesia. The authors studied the benefit of injecting local anesthesia before collagenase in reducing treatment-related pain. This prospective cohort study included 187 patients (mean age, 69 years; 80 percent men) at two orthopedic departments in Sweden. At one center, 161 consecutive patients scheduled for coll

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available for all lifeforms. Previous computational studies have given widely diverging results regarding the reaction mechanism of the enzyme. For example, some recent studies have suggested that one of the μ2-bridging sulfide ligands (S2B) may dissociate from one of the Fe ions when protonated in the doubly r

Background: Aggregation of lung cancer (LCa) in family members is well-documented. However, little is known on the familial risk of LCa when first-degree relatives (FDRs, parents or siblings) are diagnosed with LCa as a second primary malignancy (LCa-2). We aimed to investigate whether and to what extent a family history of LCa-2 was associated with an increased LCa risk. Methods: In this Swedish

Immanuel Kant wrote that the Conflict of the Faculties is a constant struggle for primacy that causes strife and ultimately undermines scholarly solidarity. His argument is a complex one, as it relates to the very ability of how to judge proper authority, what constitutes scientific truth, and how to create respect amongst a community of people representing divergent opinions. Whilst such consider

Background: We analysed the COMparison Between All immunoTherapies for Multiple Sclerosis (NCT03193866), a Swedish nationwide observational study in relapsing-remitting multiple sclerosis (RRMS), to identify trajectories of processing speed and physical disability after disease-modulating therapy (DMT) start. Methods: Using a group-modelling approach, we assessed trajectories of processing speed w

Knowledge of how biodiversity sustains ecosystem function comes predominantly from studies focused on small spatial scales. Thus, we know relatively little about the role of biodiversity at larger scales of space and time where habitats become increasingly heterogeneous. Efforts to upscale the relationship between biodiversity and function have yielded inconclusive results. Given that increasing h

The number of arrangements where academia collaborates with governmental andnongovernmental organisations, as well as industries, have increased over the last decades.While research has focused on whether knowledge produced in such collaborations is genuinelyinfluenced by others than the ‘experts’, or those with the highest status and power, this reportexplores the influence of framings and re-fra

Introduction: due to increasing coverage of antiretroviral therapy (ART), more women living with HIV have improved health condition which also increases their chances of getting pregnant. However, the knowledge about pregnancy among women receiving ART in resource-constrained settings, like Ethiopia, is limited. The aim was to assess factors associated with pregnancy among women living with HIV in

Objectives To assess whether recommendations of individually oriented lifestyle interventions (IOLIs) in guidelines from the National Institute for Health and Care Excellence (NICE) were underpinned by evidence of benefit, and whether harms and opportunity costs were considered.Design Cross sectional survey.Setting UK.Data sources NICE guidelines and supporting evidence.Eligibility criteria All NI

Background: Women with intellectual disability (ID) may encounter barriers to exercising reproductive agency, self-care during pregnancy, and accessing healthcare to optimize pregnancy outcomes. However, there is to date little evidence to guide policy and practice. We aim to fill this identified knowledge gap by examining pregnancy outcomes among women with ID in comparison with women from the ge

BACKGROUND: Despite the detrimental impact of abnormal glucose metabolism on cardiovascular prognosis after myocardial infarction (MI), diabetes is both underdiagnosed and undertreated. We investigated associations between structured diabetes care routines in cardiac rehabilitation (CR) and detection and treatment of diabetes at one-year post-MI.METHODS: Center-level data was derived from the Perf

AIM: Acute kidney injury (AKI) is a common complication of medical and surgical interventions in hospitalized patients and associates with high mortality. Our aim was to examine renal recovery and long-term survival and time trends in AKI survival.METHODS: Changes in serum creatinine (SCr) were used to define AKI in patients at Landspitali University Hospital in Iceland from 1993 to 2013. Renal re

Popular Abstract in Swedish Syftet med den aktuella forskningen är att ge en bättre förståelse av förmaksflimmer, den vanligaste rytmrubbningen i hjärtat som drabbar så många som var tionde över 70 år. Mekanismerna för förmaksflimmer är långt ifrån kartlagda, vilket bland annat leder till att behandlingen är standardiserad istället för att den beror på de mekanismer som styr varje enskild patientsThis doctoral thesis is in the field of biomedical signal processing with focus on methods for the analysis of atrial fibrillation (AF). Paper I of the present thesis addresses the challenge of extracting spatial properties of AF from body surface signals. Different parameters are extracted to estimate the preferred direction of atrial activation and the complexity of the atrial activation pattern

Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR) expression. Targeting proteins that are expressed as a down-stream effect of AR activity is a promising rationale for management of this disease. The hum

OBJECTIVE: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. METHODS: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to

Inom associationsrätten finns det personassociationer, som förenar personer, och kapitalassociationer, som förenar ett kapital. De sistnämnda har ett begränsat ansvar för delägarna, utgör egna rättssubjekt och består av ett grundkapital som väger upp det begränsade ansvaret. På grund av sina egenskaper har kapitalassociationen länge varit ett populärt val vid bolagsbildning. Uppsatsen utgör en komIn Corporate law there exist partnerships, which brings together people, and limited companies, which unites capital. The Limited company provides a limited liability for the individual co-owners, constitutes a legal entity and has an equity capital which is meant to compensate for the limited liability. Because of its characteristics limited companies have for a long time been a popular choice wh

Background: A common indicator of company long time survival and performance is its profitability. What then lies behind a company’s profits is a popular field of study, although more prescriptive than inquisitive literature has been published. One of the main reasons is that identification of what has led to an increase in profitability is extremely complex, as companies work in different micro a

Uppsatsen behandlar proportionalitet och straffteori utifrån ett amerikanskt respektive ett svenskt perspektiv. Uppsatsen utgår från en indelning som typiskt görs för att indela straffrättssystemet och avhandlar amerikansk respektive svensk straffteori utifrån ett lagstiftnings- och ett domstolsperspektiv. Det bör understrykas att uppsatsen inte är någon komparation mellan rättsystemen, utan snaraThis essay concerns the issue of proportionality in penal theory as it is applied in USA and in Sweden. The essay compares two main aspects, or levels of this proportionality; the judicial level and the court level, of each jurisdiction respectively; applying the comparative method. The essay thus addresses the federal system of American jurisprudence, and the interpreting and guiding role of th

Abstract The significance of terrestrially derived iron (Fe) for marine ecosystems and its implications on other biogeochemical cycles is well recognised. It has been recently highlighted that the concentration of Fe in several Swedish rivers has increased strongly over the last 40 years. Four rivers draining into the Baltic Sea were used in the present study in order to assess the aggregation pr