Filtyp
Objective To estimate the cardiovascular mortality among persons with bipolar disorder in Sweden compared to the general population. Design Population register-based cohort study with a 20-year follow-up. Setting Sweden. Participants The entire population of Sweden (n=10.6 million) of whom 17101 persons were diagnosed with bipolar disorder between 1987 and 2006. Main outcome measures Mortality rat
Anestesiläkare rapporterades i en svensk studie ha en högre mortalitet än genomsnittet av läkare. Detta fynd har dock ej kunnat reproduceras i motsvarande studier i de övriga nordiska länderna. Likväl har det spekulerats i om den angivna överrisken bland svenska anestesiläkare kan relateras till gruppens jourarbete med höga krav, nattarbete och stress. Kunskapen om hälsoeffekter av läkares jourarb
Popular Abstract in Swedish Detta arbete handlar om utvecklingsneurobiologi. Ett långt ord men så beskriver det också precis vad det rör sig om: biologiska studier rörande nervsystemets utveckling. Generellt sett kan man säga att utvecklings-neurobiologisk forskning på lång sikt syftar till att förstå nervsystemets utveckling såpass väl att man skall kunna använda denna kunskap för att reparera etThe striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. Sonic hedgehog (shh), a gene coding for a secreted protein has been suggested to be required for ventral telencephal
Popular Abstract in Swedish Brist på fria radikaler kan ge artrit Fagocytiska celler i vårt immunförsvar producerar fria syre-radikaler för att eliminera fagocyterade (uppätna) mikroorganismer. Produktionen av dessa syre-radikaler sker med hjälp av ett enzymkomplex (NADPH oxidas) i cellmembranet samt i membranet på de fagosomer, innehållande mikroorganismer, som bildas i och med fagocytos. MännisThe aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. Paper I a
Popular Abstract in Swedish Ehrlichia hos människor och djur Fästingburna infektioner uppmärksammas alltmer både hos människor och djur. Fästingar har visat sig kunna överföra flera olika infektiösa agens som till exempel borrelia- och ehrlichiabakterier, tick-borne encephalitis (TBE)-virus och babesia-parasiter. De i Skandinavien förekommande ehrlichia-bakterierna Ehrlichia phagocytophila, orsakEhrlichia phagocytophila is a tick-borne pathogen of domestic animals, which has recently been acknowledged also as a human pathogen. It is a strictly intracellular bacterium, infecting granulocytes of the host, sometimes resulting in clinical disease - granulocytic ehrlichiosis - with manifestations ranging from mild flu-like conditions to severe infections with multi-organ failure and death. Thi
The need for control of the influent load to a wastewater treatment plant (WWTP) is becoming more important. One reason for this is that there are a number of things that cannot be achieved with plant-focused control. For instance it is hard to avoid sludge loss as a result of poor settling or reducing a too high influent flow rate by in-plant control actions. It is also difficult to reduce the ef
α-Synuclein (α-syn), a small protein that has the intrinsic propensity to aggregate, is implicated in several neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), which are collectively known as synucleinopathies. Genetic, pathological, biochemical, and animal modeling studies provided compelling evidence that α-syn aggr
Protein-based microarrays are among the novel class of rapidly emerging proteomic technologies that will allow us to efficiently perform global proteome analysis. However, the process of designing adequate protein microarrays is a major inherent problem. In this study, we have evaluated a protein microarray platform based on nonpurified affinity-tagged single-chain (sc) Fv antibody fragments to ge
Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems has remained elusive. Here we show how coevolutionary adaptation of a specific enzy
Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chronic pain (DRCP). Patient-level data were extracted from the national prescriptions
Herbivores play a key role in the carbon (C) cycle of arctic ecosystems, but these effects are currently poorly represented within models predicting land-atmosphere interactions under future climate change. Although some studies have examined the influence of various individual species of herbivores on tundra C sequestration, few studies have directly compared the effects of different herbivore as
Zabrze is a medium size town of 200 000 inhabitants in the region of Upper Silesia, Poland. The development of the town was originally based on the exploitation of heavy industries. In the past few years Zabrze has, however, moved towards more service and tourism oriented industries. As part of this journey, the city of Zabrze sees the need to improve its existing waste management system. This rep
The incentives for traffic measurements and traffic pattern analysis are increasing. New technologies for accessing the Internet like high speed packet data services in mobile networks are deployed, which imply in many cases that users share transfer channel resources. Applications and user behaviour from a wired environment may have a negative impact on these resources. This paper discusses the n
The age and sex-specific incidence and prevalence of vertebral compression fractures were compared between the 1950s and 1980s in an urban population. In women over 80 years of age the incidence of symptomatic vertebral fractures has increased approximately four times; in elderly men even more. Mainly, low-energy trauma has caused these fractures. Thus, one clinical manifestation of osteoporosis--
Heterozygosity-fitness correlations (HFCs) at noncoding genetic markers are commonly assumed to reflect fitness effects of heterozygosity at genomewide distributed genes in partially inbred populations. However, in populations with much linkage disequilibrium (LD), HFCs may arise also as a consequence of selection on fitness loci in the local chromosomal vicinity of the markers. Recent data sugges
Wood is a material with mechanical properties that vary markedly, both within a tree and among trees. Moisture changes lead to shrinkage or swelling and modify the mechanical properties. In the present study both experimental and numerical work concerning the stiffness and the hygroexpansion properties of wood and of fibres and variations in them is presented. The experimental work involves both
Assessments of long-term changes of air quality and global radiative forcing at a large scale heavily rely on satellite aerosol optical depth (AOD) datasets, particularly their temporal binning products. Although some attempts focusing on the validation of long-term satellite AOD have been conducted, there is still a lack of comprehensive quantification and understanding of the representativeness
In the interstellar medium polycyclic aromatic hydrocarbon molecules (PAH) are exposed to strong ionizing radation leading to complex organic photochemistry. We investigated these ultrafast fragmentation reac-tions after ionization of the PAHs phenanthrene, fluorene and pyrene at a wavelength of 30.3 nm using pump probe spectroscopy at a free electron laser. We observe double ionization and afterw
