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Letters are the primitives of reading expertise. Single letter recognition relies on a hierarchy of processing stages, in which early visual features gradually evolve into abstract letter representations, but the temporal organization of these stages remains poorly understood. To address it, we applied multivariate pattern analysis (MVPA) to electroencephalography (EEG) data recorded while adult r
Effective medical education relies on clearly defined learning objectives that foster deep and meaningful learning. This article presents a consensus-driven proposal for national learning objectives in dermatology and venereology within Sweden’s new medical programme qualifying for licensure. The primary aim is to harmonize educational standards across all medical faculties and to establish a comm
Articular cartilage undergoes structural and compositional changes during osteoarthritis (OA), one of the most common joint diseases. Earlier research shows that these changes are dependent on species and joint site, and they also vary across cartilage depth. In this study, we analyzed the depth-wise proteoglycan and collagen contents, as well as collagen fibril orientation angle and fibril alignm
BackgroundAmbulance clinicians increasingly refer patients to self-care, positioning ambulance service within a wider gatekeeping role and necessitating the assessment of whether self-care is a safe option or if further support is needed. Contrary to primary healthcare centre (PHC) referrals, self-care referrals often lack structured follow-ups, with the decision consequences remaining underexplor
We have studied whether dissociation of the S2B sulfide ligand from one of its two coordinating Fe ions may affect the later parts of the reaction mechanism of nitrogenase. Such dissociation has been shown to be favourable for the E2–E4 states in the reaction mechanism, but previous studies have assumed that S2B either remains bridging or has fully dissociated from the active-site FeMo cluster. We
The steel and chemical production industries are the largest industrial emitters of greenhouse gases in the European Union, together accounting for half of the EU’s industrial greenhouse gas (GHG) emissions. A promising strategy for achieving deep GHG emissions reductions is the electrification of these two industries, which would depend on the rapid expansion of renewable electricity supply. Such
Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,0
By mutational analysis of the octamer-TATA box intervening region in the mouse SP6 κ promoter, we have mapped two octamer-dependent, costimulatory regions, A and B. The A region was active in late B cells only, while the B region was active throughout B cell differentiation. The B region was TATA proximal and contained a heptamer and an E box of the E2A type that is common in Vκ promoters. Mutatio
Human breath-hold divers usually perform a series of dives with short intervals. Repeated apneas prolong apneic time, and an accentuated diving response has been suggested to be the cause. The aim of this study was to investigate the effect of repeated apneas on apneic time and diving response in humans. Forty-one subjects performed a series of five apneas with face immersion in water of 10 degree
Alpine ecosystems harbor remarkably diverse and distinct plant communities that are characteristically limited to harsh, and cold climatic conditions. As a result of thermal limitation to species occurrence, mountainous ecosystems are considered to be particularly sensitive to climate change. Our understanding of the impact of climate change is mainly based on vascular plants however, whereas cryp
Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadt
Background: West Virginia has one of the highest rates of opioid overdose related deaths and is known as the epicenter of the opioid crisis in the United States. In an effort to reduce opioid-related harms, SB 273 was signed in 2018, and aimed to restrict opioid prescribing in West Virginia. SB 273 was enacted during a time when physician arrests and convictions had been increasing for years and w
Hernias are characterized by protrusion of an organ or tissue through its surrounding cavity and often require surgical repair. In this study we identify 65,492 cases for five hernia types in the UK Biobank and perform genome-wide association study scans for these five types and two combined groups. Our results show associated variants in all scans. Inguinal hernia has the most associations and we
This thesis explores the architectural potential of compressed wool as a natural material capable of forming complex structures. From the beginning, the project combined two main directions: first, the exploration of natural, growth-based patterns such as differential growth and hyperbolic surfaces, and second, the investigation of material behavior through direct experimentation. These two paths
Titeln på detta arbete, Häng med i svängarna!, kommer från en av våra frågeställningar: ”Vilka färdigheter bör en modern trumslagare inneha för att vara så förberedd som möjligt på dagens musikaliska landskap?” Detta grundar sig i en idé om att en modern trumslagare bör införskaffa sig de moderna färdigheter som behövs för att helt enkelt hänga med i svängarna, eller att hänga med i det moderna. SGet with the groove, the title of this study, is derived from one of our central research questions: ”What skills should a modern drummer possess in order to be as prepared as possible for today’s musical landscape?” This question stems from the idea that today’s drummer must acquire contemporary skills necessary to – quite simply – get with the groove: to stay relevant and in sync with the demand
Background: Change is something all organizations experience, and in the fast-paced business-world that is today, the ability to change needs to be higher than ever. The problem is, individuals hate change, it is in our genes to resist it, which complicates how organizations can navigate the change-landscape. To solve this, new ways to work with change arise every day and the latest trend: change
This master thesis investigates how a manufacturing company develops and implements packaging solutions for sustainable development, using ASSA ABLOY as a case study. Focusing on the sliding door operator produced at a manufacturing plant in Eastern Europe, the study explores the environmental and economic impacts of packaging throughout its life cycle and the internal packaging innovation process
OBJECTIVE: Inter-regional comparison of health-reform outcomes in south-eastern Europe (SEE).METHODS: Macro-indicators were obtained from the WHO Health for All Database. Inter-regional comparison among post-Semashko, former Yugoslavia, and prior-1989-free-market SEE economies was conducted.RESULTS: United Nations Development Program Human Development Index growth was strongest among prior-free-ma
"A brief history of sound art is, in a nutshell, a history of sonic forms of expression that throughout the twentieth century can be traced within music, the visual arts, and contemporary dance, as well as in performance art, conceptual art, and media art. Attempts to capture sound art as a detached and isolated art form or artistic phenomenon have been made, but this is definitely not the approac
