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The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a
Popular Abstract in Swedish Syn är avgörande för många djurs överlevnad. En väldigt viktig del av ögat är linsen då ljuset fokuseras genom den. I denna studie har jag undersökt hur fisklinser fokuserar ljus. Valet av fiskar som försöksdjur berodde på att de är lätta att skaffa och deras linser är klotformade, vilket underlättar beräkningen av strålgången och linsens optiska egenskaper. Hos fiskar Vision is an important source of information for many animals. The lens plays a central role in the visual pathway and hence the ecology of these animals. Fish have spherically shaped crystalline lenses that contain a gradient of refractive index. Like all refracting elements, lens performance depends on the wavelength of the refracted light. This wavelength dependent focusing leads to chromatic a
Avhandlingen behandlar den socialistiska respektive den liberala internationella fredsrörelse som agerade under kvartsseklet före första världskrigets utbrott 1914.During the 25 years before the First World War in 1914 two different kinds of peace movements, one bourgeois-liberal and one socialist, were organised to fight militarism and war. The two movements – represented by the International Peace Bureau and the Second International, respectively – grew in size between 1889 and 1914. At the beginning of 1914, IPB organized over 200 peace associations, repr
Stalkningföreteelsen blev under 2011 lagstadgat genom införandet av 4 kap. 4b§ BrB och fick den straffrättsliga benämningen olaga förföljelse. I bestämmelsen uppräknas tio olika brott som, då de har begåtts på ett sätt som kan anses utgöra en förföljelse och kränkt målsägandes integritet, konstituerar brottet olaga förföljelse. Ett av de brott som räknas upp i bestämmelsen är överträdelser av ett
När beslut skall fattas rörande barn förekommer det situationer där flera olika lagstiftningar skall bedömas. När vårdåtgärder på barn aktualiseras skall hälso- och sjukvårdens lagstiftning parallellt tillämpas med föräldrabalkens bestämmelser om vårdnadshavarens ansvar och barnets växande autonomi. Grundlagen och hälso- och sjukvårdslagen ställer upp krav på att ett samtycke skall föreligga för aWhen considering measures to children, there are situations where several different acts of legislation must be assessed. When care measures in children being addressed the health care legislation applies in parallel with parental code provisions of the guardian's responsibility and the child's growing autonomy. The Constitution and Health Act sets out a requirement that a consent must be
Metaphors is a vital and fundamental part of our intellectual abilities. We invent metaphors, but they construct our conceptual thinking in means that they decide in what way we think of phenomenas of which we have no clear knowledge about. To analyze the source domains from which the metaphors are taken is a most fruitful way of gaining information about a metaphor. In comparison to the target do
Catalonia is a nation with it's own language, its own culture, own policy and own history it is said. A non-independent nation that is living it's ordinary life flagging its banal symbols as if it al ready was an independent state. Some catalanistas assert that this kind of weirdness could be the death row for Catalonia and its future as in independent nation of its own. They state that it
The aim of this thesis is to investigate the Canadian government’s stance on addressing the issue of missing and murdered Indigenous women, and to perform an analysis of ongoing violence and asymmetric conflict in Indigenous-Government of Canada relations. The Canadian government’s approach in regards to holding a national inquiry into the issue of missing and murdered Indigenous women in Canada w
This study investigates how regionalism and regional identity is perceived and promoted in the Oresund region including a specific focus on Malmö, particularly from the perspective of the Oresund committee as an actor. The relevance of this focus is sanctioned by reported growth of regionalism in the Oresund region, and the sparse amount of research in whether organizations and their work could be
Previous research has uncovered that immigrants from Somalia are one immigrant group that have struggled to integrate in Sweden. In light of this, I employ an ethnic-based approach with the intent to understand the difficulties that immigrants from Somalia encounter in Sweden by examining their own perceptions of integration. The study utilizes a qualitative case study approach and draws on data c
The purpose of this study was to find out if gambling addicts experience turning points in their process to recover from their addiction. A qualitative approach with life chart method and semi structured interview was used. Fuchs Ebaugh theory about role exit and turning points was theoretical basis. The result is that every gambling addict in this study experienced one or several turning points d
Background: Sexual dysfunction is common following a cancer diagnosis in young adulthood (18–39 years) and problems related to sex life are ranked among the core concerns in this age group. Yet, few studies have investigated to what extent adults younger than 40, receive information from healthcare providers about the potential impact of cancer and its treatment on their sex life. Methods: A popul
The covid-19 pandemic was characterized by a series of variants of concern, different strains of SARS-CoV-2 which had a serious impact on transmission. One of these, denoted Omicron, dominated in early 2022 and caused covid-19 cases to soar. The increased transmission during the Omicron wave triggered hospitals to further strengthen airborne precautions. The reason for this surge in cases during O
Populärvetenskaplig sammanfattning: Naturbetesmarkerna minskade med 86,7% från 1927 till 1990. Denna minskning är alarmerande eftersom många idag hotade och sällsynta arter är beroende av dessa. En stor del av anledningen till detta är att staten ända in på 1980-talet i sin rådgivning danade för att dessa marker antingen skulle bearbetas med konstgödsel och ogräsbekämpning eller planteras med trädThe rural landscape of Sweden has changed rapidly during the 20:th century. Measurements from 1927 compared to those from 1990 show that the area of non managed pasture in Sweden has declined by 86.7 %. Since a lot of threatened and rare species are dependent of this kind of land, these figures are alarming. During the last 30-40 years non managed pasture has declined due to abandonment, tree plan
Over the centuries the Mayan indigenous population has been excluded from power politics in Guatemala. During the last decades much attention by scholars has been placed on the Mayan movement, as a new and unconventional political actor. In this study I examine why and how this actor has emerged, with specific consideration on the shift from class to culture. By drawing on theories of civil societ
This paper uses data from a 2010 Swedish nationwide survey (done in cooperation with the SOM institute in Gothenburg) in order to study whether citizens who engage in participatory activities, especially signing petitions, while using sites like Facebook share demographic and other features with citizens who are known from previous studies to be more likely to participate in politics. Does the m
BACKGROUND: The St Gallen 2019 guidelines for primary therapy of early breast cancer recommend omission of completion axillary lymph node dissection (cALND), regardless of histological type, in patients with one or two sentinel lymph node (SLN) metastases. Concurrently, adjuvant chemotherapy is endorsed for luminal A-like disease with four or more axillary lymph node (ALN) metastases. The aim of t
It is a wellknown fact that the books of the Hebrew Bible are, to a great extent, anonymous and that the individuals long identified as their authors (Moses, Isaiah, David, Solomon, and so on) are not the ones who have penned them. How, then, should the few paratexts that do, in fact, relate texts explicitly to named individuals be understood? In this article, I argue that such a question is essen
Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have
