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Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 x 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703

Objective: The objective of this study was to examine the prevalence of selfreported experiences of potential childhood traumas and polytraumatization, and to find cut-off values for different kinds of potential traumatic events in a national representative sample of adults in Sweden. In addition, to analyse the association between polytraumatization and both psychological distress and global self

The integration of peer support workers (PSW) into the mental health services workforce has offered additional avenues to strengthen service provision. In Sweden, the availability of peer support workers has grown significantly over the past decade, yet there has been insufficient investigation into their organization and implementation. Consequently, there is a growing need for further research i

Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,0

As informal human settlements grow in some major urban centers throughout the developing world, the problem of poverty is being exacerbated by escalating waste generation. Poor sanitation and substandard living conditions in these settlements pose major health risks for millions of marginalized people. Many have resorted to working informally in unhealthy and unsafe conditions to scrounge through

In 2003 France introduced an ecologic protection zone off its Mediterranean coast. In that zone France has jurisdiction regarding environmental protection. This thesis will examine whether the zone is in conformity with existing international law and whether it was a necessary measure despite all the existing environmental protection in the Mediterranean Sea area. The thesis is structured as a com

Under de senaste åren har terrorattentat i Kenya uppmärksammats och diskuterats. Efter 9/11 har Kenya blivit det land i Afrika som har klassats som en frontlinje för att bekämpa terrorismen tillsammans med USA. I samband med Kenyas terrorismbekämpning har handlingar mot somaliska flyktingar ifrågasatts och Human Rights Watch är en av de organisationer som har rapporterat om händelser under en långIn recent years, terror attacks in Kenya have been observed and discussed. After 9/11 Kenya has become the frontline of Africa, fighting terrorism alongside the United States. As a result of the fight against terrorism, questions regarding the treatment of Somalian refugees arise. Human Rights Watch is one of many organizations to rapport on such events for a period of time. With this in mind, the

Svällningsstudier med gelatin Av: Victor Norgren, Lunds tekniska högskola, 2015-06-15 Introduktion Gelatin är en genomskinlig proteinbaserad biopolymer, som tillverkas av kollagen. Kollagen är bindningsvävnaden som fäster musklerna till benen i kroppen. Genom att t.ex. koka benknotorna kan man utvinna kollagenet som blir gelatin när det tillåts sätta sig igen. Gelatintrådarna behåller den spiralThis report is about the measurements of swelling gelatine films of different thickness and at different temperature. The research has been mainly focused on finding a suitable model. Results have shown that the new Pseudo-Sigmoidal Model (PSM) is superior to previous quasi-second order models such as the Robinson and Ofner model. It has also been shown that gelatine’s swelling can be divided into

Genom det statliga maktmonopolet har svensk polis tilldelats vissa våldsbefogenheter för att kunna upprätthålla allmän ordning och säkerhet samt förebygga och förhindra brott. Polisens rätt att bruka våld regleras delvis i 10 § polislagen och delvis i de allmänna ansvarsfrihetsgrunderna i 24 kap brottsbalken. Senaste åren har frågan om polisens våldsbefogenheter aktualiserats allt mer i takt med eSwedish police have been granted an authority to use force to maintain public order and safety besides preventing and prosecuting crime. The Police use of force is regulated in Article 10 of the Police Act and in the general grounds for exemption in Chapter 24 of the Penal Code. Since police violence has increased the last couple of years’, questions have been raised regarding the right to use for

Introduktion. Patienter med bipolär sjukdom har ofta kognitiv funktionsnedsättning, vilket predicerar nedsatt psykosocial funktion. På senare tid har behandlingsprogram i funktionell remediering tagits fram, i syfte att avhjälpa detta.Forskning rörande acceptans av kognitiv dysfunktion saknas. Föreliggande studie syftade dels till att undersöka psykosocial funktion och grad av acceptans av kognitiIntroduction. Cognitive functioning of patients with bipolar disorder is often impaired, predicting impaired psychosocial functioning. Lately, programs of functional remediation attempting to address these difficulties, have been developed. Acceptance of cognitive dysfunction has not been scientifically explored. The present study aimed at investigating psychosocial functioning and acceptance of c

Landskapsförändringar är ett av de pågående hot som idag leder till en global förlust av arter. Vilda pollinerande insekter, framförallt humlor och solitärbin men även dagfjärilar, svärmare och blomflugor, spelar en mycket viktig roll för den globala biodiversiteten. Dessa arter minskar över hela världen, till stor del på grund av landskapsförändringar till följd av exempelvis urbanisering. Genom Biodiversity loss has been observed globally. Landscape change and fragmentation are the driving causes of this loss, and urbanisation one of the reasons. Pollinating insects are an important organism group as they contribute to the diversity of the wild flora as well as the global food production by performing the ecosystem service pollination. By taking measures to promote pollinating insects in

Papillomavirus, the leading cause of cervical cancer Papillomaviruses are family of viruses that infect mammals and their uncured infection can lead to cancer. In humans, they can cause as much as 5% of all the cancers worldwide. Even though some papillomavirus types can also cause warts on hands and feet that will clear on its own, some types, regarded as high-risk by specialists, can infect the

Supramolekulär kemi är ett fält inom kemi där samlingar av molekyler som hålls ihop av olika ickebindande interaktioner mellan molekylerna studeras. Dessa bindingar kan ses som två legobitar som sätts ihop, där legobitarna är molekylerna och det ickebindinade interaktionerna är passformen som håller dem på plats. Legobitarna kan tas isär med mindre kraft än vad det krävs för att dela en bit lego. Hydrogen bonding based self-assembly is prevalent throughout nature dictating the folding of proteins and DNA. Hydrogen bonding has been utilized for self-assembly of small monomers into aggregates of varying size and shape. Potential applications of these aggregates could be creation of ion channels, formation of inclusion complex for delivery of drugs or capture of hazardous material in water su

Wireless power transfer is emerging into everyday life. The idea is to create a more convenient way of charging, or at least powering, devices. Ideally, all power transmitters and power-receiving devices should be interoperable so that the user does not need to investigate whether a specific power transmitter will work together with a specific device. Interoperability is what the standard Qi, inve

Människor upplever universellt emotioner dagligen som påverkar deras beteende. Syftet med studien är därför att se hur träning och träningsintensitet relaterar till emotioner och hur träning fungerar som ett verktyg för att ta sig an emotioner. Forskningsfrågan var därför ”Hur ser sambandet ut mellan akut träning och träningsintensitet med känsloavlastning, problemfokus samt prokrastinering?”. DärPeople universally experience emotions daily that affect their behavior. The purpose of this study is to see how exercise and exercise intensity relate and how exercise acts like a tool to manage their emotions. The research question was therefore: “Is there a connection between exercise and exercise intensity with emotional relief, focus and procrastination?”. The study’s hypothesis is that acute

A fundamental postulate of quantum mechanics is that the Hamiltonian of a closed system is Hermitian, guaranteeing real-valued energies and conserved probabilities throughout the evolution of the system. However, for quantum systems where there is dissipation and crosstalk with the environment, such as a system of quantum dots connected to an environment of metallic leads, the dynamics of the syst

The aim of this study was to explore how healthcare counselors in their role as child representatives at adult habilitation clinics in Sweden experience the implementation of support for children as next of kin. Healthcare law in Sweden states that children as next of kin are entitled to information, advice and support by healthcare professionals when living together with an adult relative that ha

What does the relationship between the artistic research and the university library look like? Artistic research has been a practice in Sweden for several decades, but it was first in 2010 that the artistic research was given its own form of third-cycle education. In this study artistic research is intended to be understood as the research within the artistic practice. Therefore, the research

The main topic of this thesis is the storage location assignment problem, which can also be seen as a traveling salesman problem. The objective is to find the shortest path between items to be picked at a medium-sized warehouse. Orders come in batches consisting of items that will be assembled in-house. Therefore, it is essential to pick up all the items contained in the batch before they are drop