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Background: More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods. Material and methods: A summary is given from recently published meta-analyses on three possible clinical applications of human papillomavirus (HPV)-DNA testing: triage of women with equivocal or low-grade cytolog
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Technology for cardiac output (CO) and blood volume measurements has been developed based on blood dilution with a small bolus of physiologic body temperature saline, which, after transcardiopulmonary mixing, is detected with ultrasound sensors attached to an extracorporeal arteriovenous loop using existing
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and cell death in cartilage are among the first signs
Background: Co-cultures and cell immobilization have been used for retaining biomass in a bioreactor, with the aim to improve the volumetric hydrogen productivity (QH2). Caldicellulosiruptor kronotskyensis is a strong cellulolytic species that possesses tāpirin proteins for attaching on lignocellulosic materials. C. owensensis has its reputation as a biofilm former. It was investigated whether con
Background: The risk of inflammatory diseases is sex-dependent, but it remains unknown whether this is due to the impact of sex hormones or sex chromosomes. Transgender individuals represent a unique cohort for studying the relative influence of endocrine and chromosomal factors. Here we compared serum levels of B-cell activating-factor (BAFF) and tumor necrosis factor (TNF) in transgender men (TM
Objectives: The aim was to explore the association between neighborhood deprivation and all-cause mortality and cause-specific mortalities in patients with schizophrenia and bipolar disorder. A better understanding of this potential relationship may help to identify patients with schizophrenia and bipolar disorder with an increased mortality risk. Methods: This nationwide study included practicall
Background: Patients with Dupuytren disease experience various activity limitations. Treatment aims to reduce finger joint contractures to improve hand function and activity performance. For assessing improvement different patient-centered measures have been used. The Canadian Occupational Performance Measure (COPM) was developed as an interview-based outcome measure to detect changes over time in
Background: Primary Sclerosing Cholangitis (PSC) is a hepatobiliary disease closely related to ulcerative colitis (UC). In PSC patients, colectomy has been linked to improved prognosis, especially following liver transplantation. This suggests an involvement of the gut-liver axis in PSC etiology. Objective: We aimed to investigate the association between colectomy and the risk of future PSC in an
Background: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous condition predominantly affecting autonomic control of the cardiovascular system. Its extensive symptom diversity implies multi-organ involvement that interacts in ways still requiring full exploration. Current understanding of POTS pathophysiology suggests alterations in the renin–angiotensin–aldosterone system as a p
This guide presents a joint effort of projects funded under the European Research Area for Climate Services (ERA4CS) (http://www.jpi-climate.eu/ERA4CS), a co- funded action initiated by JPI Climate with co-funding by the European Union (Grant 690462), 15 national public Research Funding Organisations (RFOs), and 30 Research Performing Organisations (RPOs) from 18 European countries. This guide set
EU har under de senaste åren satt upp målet att bli klimatneutral till 2050. För att nå upp till målet har EU-kommissionen identifierat att det behövs en massiv ekonomisk investering i hållbara ekonomiska aktiviteter runt om i EU. Denna omställning kan inte lösas utan stöd från privata investeringar och som en lösning på detta har EU-kommissionen infört EU:s gröna taxonomi som ska hjälpa entiteterThe EU has over the last few years set up the objective to become climate neutral by the year 2050. To achieve this objective, the European Commission has recognised the need for a massive transition investment into sustainable economic activities. The European Commission has also recognised that this investment cannot be done without the help of private funding which is why the European Commissio
Sexköpslagen trädde ikraft den 1 januari 1999 då Sverige, som första land i världen, förbjöd köp av sexuella tjänster i syfte att bekämpa prostitutionen. För att en kriminalisering ska anses vara befogad måste det finnas ett tydligt intresse som strafflagstiftningen avser att skydda. Vilka intressen som bedöms värda att skydda varierar dock i takt med att samhället utvecklas och kan därför komma aThe sex purchase act was established on the first of January 1999 when Sweden, as the first country in the world to do so, prohibited purchase of sexual favors in order to combat the prostitution. There has to be a clear interest, a so-called protective interest, that the criminal law intends to protect in order for a criminalization to be justified. The interests that are deemed worthy of protect
Due to the world’s growing population and an increase in food demand, new innovative food products need to be developed to maximize the use of limited farmland. Because of global warming and the fact that plant based products generate less greenhouse gases than meat based products, research should focus on new plant-based protein sources. Rapeseed press cake is a residue from rapeseed oil producti
Åklagarens objektivitetsplikt har under de senaste åren blivit särskilt uppmärksammad med anledning av Thomas Quick-fallet. Under 90-talet erkände Quick ett 30-tal mord, varav han blev dömd för åtta av dem. Emellertid förändrades allt år 2008 när Quick tog tillbaka sina erkännanden. Detta ledde till ett antal omprövningar, där han så småningom blev friad från samtliga åtal. I såväl domstolar som m
Popular science summary: Transcriptional regulation of HIF-2α in neuroblastoma Neuroblastoma is the most common solid tumor in childhood. The presence of hypoxia -regions of low levels of oxygen- causes a more immature tumor phenotype that is related to a more aggressive form of this cancer. Hypoxia is mainly directed by Hypoxia Inducible Factors (HIF)-1α and HIF-2α. High levels of HIF-2α expre
Abstract Breast cancer is the most commonly diagnosed type of cancer in women worldwide. Inherited or acquired aberrations of genes in DNA damage repair, cell cycle checkpoint, apoptosis, and growth signaling pathways are responsible for the generation of breast cancer. Recently, increasing evidence shows that signaling pathways can be highly interconnected and are interacting with each other rat
INTRODUCTION: Cognitive impairment is common in parkinsonian disorders, but its extent among older adults with subtle motor abnormalities without a diagnosed movement disorder remains unclear. We examined cognitive decline, domain-specific cognitive function and incident dementia in older adults with subthreshold parkinsonism and parkinsonism (primary analysis). Sensitivity analyses were repeated
The aim of this study is to analyze the change of Basque nationalism during the last ten years and discuss how the main nationalist party (PNV) tries to impose "we"- feelings and support for its cause. Theories of nationalism and national identity are used in the analysis. A textual analysis of PNV:s unofficial documents is discussed and compared with a discourse analysis of its officia
The breakup of the L-chondrite parent body (LCPB) in the mid-Ordovician is the largest documented asteroid breakup event during the past 3 Gyr. It affected Earth by a dramatic increase in the flux of L-chondritic material and left prominent traces in both meteorite and sedimentary records. A precise constraint on the timing of the LCPB breakup is important when evaluating the terrestrial biotic an
