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Recombinant factor IX Fc for the treatment of hemophilia B

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity

Accurate detection of SARS-CoV-2 neutralizing antibody (nAb) is critical for assessing the immunity levels after virus infection or vaccination. As fast, cost-effective alternatives to viral infection-based assays, competitive binding (CB) assays were developed to quantitate nAb by monitoring the ability of sera to inhibit the binding of viral spike (S) protein to the angiotensin converting enzyme

0731PDF_Computational modeling strategy of steel connections

0731PDF_Computational modeling strategy of steel connections Master’s Dissertation Structural Mechanics Report TV SM -5235 C A RL-M IC H A EL BJÄ LKEN SÄTER and C A RL H O LM G REN C O M PU TA TIO N A L M O D ELIN G STR A TEG Y O F STEEL C O N N EC TIO N S CARL-MICHAEL BJÄLKENSÄTER and CARL HOLMGREN COMPUTATIONAL MODELING STRATEGY OF STEEL CONNECTIONS 5235HO.indd 15235HO.indd 1 2019-08-08 20:50:53

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5235.pdf - 2026-05-30

Factor H–IgG chimeric proteins as a therapeutic approach against the gram-positive bacterial pathogen Streptococcus pyogenes

Bacteria can cause life-threatening infections, such as pneumonia, meningitis, or sepsis. Antibiotic therapy is a mainstay of treatment, although antimicrobial resistance has drastically increased over the years. Unfortunately, safe and effective vaccines against most pathogens have not yet been approved, and thus developing alternative treatments is important. We analyzed the efficiency of factor

Hur reagerar fotbollsklubbars aktiekurser på spelartransaktioner och kvalifikationsmomentet till Champions League?

Syftet med uppsatsen var att studera hur börsnoterade fotbollsklubbars aktier reagerar vid spelartransaktioner och vid kvalifikationsmomentet till Champions League. För att genomföra denna undersökning använde vi oss av en kvantitaitv metod, där vi studerade spelartransaktioner och kvalifikationsmomentet till Champions League enligt Event study teknik. Empirins utgörs av börskurser från de fyra kl

Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

Stroke causes direct structural damage to local brain networks and indirect functional damage to distant brain regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected to the site of injury. Spontaneous functional recovery can be enhanced by rehabilitative strategies, which provides experience-driven cell s

Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema du