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Background Influenza and other respiratory viruses promote Streptococcus pneumoniae proliferation in the upper respiratory tract. We sought to investigate for what we believe is the first time, the effect of intranasal live attenuated influenza vaccine (LAIV) on nasopharyngeal S pneumoniae density in a low-income to middle-income country population with high pneumococcal carriage rates. Methods I
Background and objectives: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there is limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. Study I aimed to investigate whether there are coherent changes in CSF inflammation associated with central sensitization (CS), and to evaluate po
Barnobesitas är sedan flera år ett ökat hälsoproblem bland barn. Obesitas vid 4 års ålder ger en kraftigt ökad risk för obesitas senare i livet. Att förebygga uppkomst och utveckling av obesitas är en långsiktig investering för framtiden. Idag finns ingen evidensbaserad metod för vägledning inom barnhälsovården för att främja hälsosamma levnadsvanor och förebygga obesitas hos förskolebarn. Det övePrevention of childhood obesity with its effects on children’s mental and physical health and well-being is an international public health priority and is suggested to be effective when started early. As Child Health Services lack an evidence-based model, there is the need for development of a low-intensive health promotion model that is feasible and cost-effective in preventing obesity in prescho
Objective: To report outcomes of urgent juxtarenal/pararenal aneurysms (J/P-AAAs) managed by off-the-shelf multibranched thoracoabdominal endografts (Cook, T-branch). Methods: In this observational, multicenter, retrospective study, patients with J/P-AAAs treated by urgent endovascular repair by T-branch in 23 European aortic centers, from 2013 to 2023, were analyzed. Contained J/P-AAAs rupture, p
This study aims to investigate and disentangle the impact of land use and climate variability on the Baltic Sea coastal zone from a millennial perspective. To assess the environmental status of the coastal zone we make use of siliceous microfossils (mainly diatoms), stable nitrogen and carbon isotopes, organic carbon accumulation rates, and lithological changes analyzed in a sediment core collecte
Popular Abstract in Swedish Avhandlingen handlar om hur fett (lipider) i kosten bryts ner och transporteras i blodet för att slutligen antingen användas som energi, byggstenar i cellväggarna eller lagras i fettväven. I den här avhandlingen kan man också läsa om hur man kan modifiera fetter med hjälp av speciella proteiner: enzymer för att förbättra näringsinnehållet och dess fysikaliska egenskaperAn important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly
Ultrasonic motors (USMs) have been extensively studied for three decades, due to their attractive features, such as high torque at low speed, simple structure, and precise positioning capability. However, since USMs are driven by the friction force between the rotor and the stator in most cases, they inherently possess the friction loss and the wear of contact materials, which cause their low effi
Importance: Long-term follow-up after transcatheter aortic valve replacement (TAVR) is of interest given that longitudinal data on mortality and durability of transcatheter heart valves are limited. The REPRISE III (Repositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Valve System-Randomized Clinical Evaluation) randomized clinical trial compared the mecha
Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients
Background: The apolipoprotein E (APOE) ε4 allele is associated with higher cholesterol levels, and an increased risk of developing Alzheimer’s disease (AD) and amyloid-related imaging abnormalities after initiation of amyloid-modifying therapies. A worse cognitive response to cholinesterase inhibitor (ChEI) treatment and longitudinal outcome in APOE ε4-carriers has been observed. Based on these c
IMPORTANCE: Prostate-specific antigen (PSA) screening has potential to reduce prostate cancer mortality but frequently detects prostate cancer that is not clinically important.OBJECTIVE: To describe rates of low-grade (grade group 1) and high-grade (grade groups 2-5) prostate cancer identified among men invited to participate in a prostate cancer screening protocol consisting of a PSA test, a 4-ka
Importance: Recent studies have questioned the presumed low-risk status of patients with asymptomatic nonsevere aortic stenosis (AS). Whether annual N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements are useful for risk assessment is unknown. Objective: To assess the association of annual NT-proBNP measurements with clinical outcomes in patients with nonsevere AS. Design, Setting, a
Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functiona
Background Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. Methods In t
Frågan om bevisning utgör en viktig fråga även i skiljeförfaranden. I synnerhet skriftlig bevisning är viktig då den överlag anses vara mer tillförlitlig än muntlig sådan. Det är därför av vikt att part får tillgång till all skriftlig bevisning, även sådan som motpart eller annan kan tänkas inneha. Om dessa dokument frivilligt företes av part eller tredje man uppstår inga problem. Problemen börjar
Chemical Loping Combustion (CLC) is a novel combustion technology in which the exhaust gas is inherently divided into oxygen depleted air in one stream and CO2 and water vapour in another. This is however under the ideal condition that the fuel conversion is complete, i.e. all the hydrocarbons in the fuel is transformed to heat, water vapour and CO2. The CO2 capture rate can under such ideal condi
Background and purpose: During radiotherapy, rectal cancer patients show inter-fractional internal motion that effects the delivered dose distribution. The purpose of this work is to study I) the inter-fractional bladder volume change, II) the effect of bladder volume change on bowel dose distribution, III) the effect of bladder optimization on the relationship between bladder volume and bowel dos
Background and aim: The Barsebäck nuclear power plant (NPP) units ceased operations in 1999 and 2005. Now the NPP is in the phase of decommissioning, which is a complicated process that will take many years to complete. Radiological characterization of the surrounding area is a part of the decommissioning process. The aim of this thesis was to identify and quantify residual anthropogenic radioacti
SED Report 2017 Destinations This publication should be cited as: International Institute for Industrial Environmental Economics [IIIEE]. 2017. Rays of Sunshine: Tales of Sustainable Transitions. Lund: IIIEE ISBN: 978-91-87357-28-2 Alentejo, Portugal Berlin, Germany Zabrze, Poland Wonsho, Ethiopia Deva, RomaniaNakuru, Kenya Content Food for Thought: Developing Horticulture Sustainably in Nakuru Co
https://www.iiiee.lu.se/sites/iiiee.lu.se/files/final_report_sed_emp_rays_of_sunshine_2017_0.pdf - 2026-06-29
