Filtyp
In this paper, we revisit the rotation averaging problem applied in global Structure-from-Motion pipelines. We argue that the main problem of current methods is the minimized cost function that is only weakly connected with the input data via the estimated epipolar geometries. We propose to better model the underlying noise distributions by directly propagating the uncertainty from the point corre
To explore mechanisms of B-incorporation in common chain silicates we have investigated synthetic diopside samples produced under boron-saturated conditions by B-11 and Si-29 magic-angle spinning (MAS) NMR and single-crystal NRA, FTIR, EMP and XRD/SREF techniques. Our samples contain 0.14-0.65 wt.% B2O3. NMR reveals that B is predominantly present in trigonal coordination in the clinopyroxene stru
In this work, we employ density functional theory to assign vibrational signatures of [FeFe]-hydrogenase intermediates to molecular structures. For this purpose, we perform an exhaustive analysis of structures and harmonic vibrations of a series of CN and CO containing model clusters of the [FeFe]-hydrogenase enzyme active site considering also different charges, counterions, and solvents. The pur
Reference Attribute Grammars (RAGs) is a declarative executable formalism used for constructing compilers and related tools. Existing implementations support concurrent evaluation only with global evaluation locks. This may lead to long latencies in interactive tools, where interactive and background threads query attributes concurrently.We present lock-free algorithms for concurrent attribute ev
Bakgrund: I bygg- och anläggningsbranschen skedde 1470 olyckor år 2018 där några även ledde till dödlig utgång (Arbetsmiljöverket, 2018). Utbildningen till maskinförare idag är både lång men grundlig och ger maskinföraren de förutsättningar som krävs för att framföra ett anläggningsfordon på ett säkert sätt på en byggarbetsplats. Genom regleringar från arbetsmiljöverket och förebyggande åtgärder aBackground: In the construction industry a total 1470 accidents occurred 2018 where some of them also led to fatal outcome (Arbetsmiljöverket, 2018). The qualification to be a construction machine operator are both long and thorough and will give the operator the prerequisites to convey the construction machine in a safe way on different construction sites. Through regulations from Arbetsmiljöverk
Att samarbeta med dina kursare är ett bra sätt att få ut mer av studierna – både när det är läraren som har bestämt att ni ska grupparbeta och när ni har bildat en frivillig studiegrupp. Men grupparbete kräver planering och struktur för att fungera. Att grupparbeta kan kännas krångligt, särskilt om man inte känner varandra. Det kan vara knepigt att hitta tider när alla kan vara på samma ställe och
https://www.campusonline.lu.se/studieteknik/grupparbeta-effektivt-med-motesteknik - 2026-07-15
Professor Contact details Email: ulf [dot] ryde [at] chem [dot] lu [dot] se Phone: +46 46 222 45 02 Mobile: +46 73 065 53 57Organisation Computational Chemistry Service point: 1 WebpageUlf Rydes profile in Lund University research portalOther affiliations Member of Strategic Research Area eSSENCE: The e-Science CollaborationResearch areasBiochemical molecules studied by theoretical methods.The rel
https://www.compchem.lu.se/ulf-ryde - 2026-07-15
BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy.METHODS: The nomogram was developed in a training cohort (n=955) from the CALY
A desalting step using reversed phase chromatography is a common practice prior to mass spectrometry analysis of proteolytic digests in spite of the detrimental exclusion of the hydrophilic peptides. The detection of such peptides is also important for the complete coverage of protein sequences and the analysis of posttranslational modifications as inquired by regulatory agencies for the commercia
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic variation in cord blood and body composition in the offspring. Genome-wide DNA methylation was analyzed in cord blood from 208 offspring from the Treatment of Obese P
Background: The proteome of the serine protease prostate-specific antigen (PSA) and its enzymatic properties have been clarified only recently. We have developed a specific and sensitive method for the measurement of active PSA and used it to measure proPSA in blood. Methods: We used the synthetic peptide KGISSQY, which possesses a PSA-specific cleavage site, as substrate. To ascertain the specifi
Biomolecular solutions and amphiphilic liquid crystals are studied by Nuclear Magnetic Resonance Dispersion (NMRD) and Pulsed-Gradient Spin Echo (PGSE) respectively. A random-flight simulation is performed to obtain the obstructing factors for self-diffusion of small molecules in macrofluids. The accuracy of existing mean-field approximations for the obstruction factors is analyzed. The orientatio
We have analyzed the content of N-unsubstituted glucosamine in heparan sulfate from glypican-1 synthesized by endothelial cells during inhibition of (a) intracellular progression by brefeldin A, (b) heparan sulfate degradation by suramin, and/or (c) endogenous nitrite formation. Glypican-1 from brefeldin A-treated cells carried heparan sulfate chains that were extensively degraded by nitrous acid
FKBP12, a small human enzyme, aids protein folding by catalyzing cis-trans isomerization of peptidyl-prolyl bonds, and is involved in cell signaling pathways, calcium regulation, and the immune response. The underlying molecular mechanisms are not fully understood, but it is well-known that aromatic residues in the active site and neighboring loops are important for substrate binding and catalysis
The effect molecular crowding, defined as the volume exclusion exerted by one soluble inert molecule upon another soluble molecule, has on the structure and self-interaction of lipid-free apoA-I were explored. The influence of molecular crowding on lipid-free apoA-I oligomerization and internal dynamics has been analyzed using electron paramagnetic resonance (EPR) spectroscopy measurements of nitr
Computational methods gained a widespread use in drug discovery. Understanding conformational dynamics of protein and mechanisms of protein-ligand binding are two major areas in drug discovery. Molecular dynamics (MD) simulation have been routinely used to study conformational dynamics of protein and mechanisms of protein-ligand binding. In classical MD simulation, the system often remains stuck i
Background: The nature of free, uncomplexed prostate-specific antigen (s) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies using PSA produced by a metastasized cancer cell line, LNCaP, as an immunogen. Methods: Hybridoma cell lines were screened with different methods that aimed at finding antibodies specific for the forms of free PSA produced by LNCaP cel
The increase in extreme weather confirms that in order to slow down climate change, unnecessary travel must be reduced. Consequently, tourism industry has an obligation to start launching more environmentally friendly travel concepts and replace destructive charter tourism until sufficient emission-free vehicles that run on electricity become norm. Developing Staycation into innovative and attract
