Sökresultat

Popular Abstract in Swedish Osteopetros är ett samlingsnamn för en grupp av sjukdomar som påverkar benombildningen i vår kropp. Denna term kan lätt förväxlas med den betydligt vanligare sjukdomen osteoporos (benskörhet). Trots ordens snarlikhet skiljer sig dessa sjukdomar sig avsevärt från varandra. Osteo är latin för ben och medan poros kan översättas med porös betyder petros sten. Även om de oliThe goal in this thesis is development of gene therapy for malignant infantile osteopetrosis (IMO), a rare but severe genetic bone disease. The concept of osteopetrosis implies dysfunction or lack of osteoclasts, the bone resorbing cells in our body, resulting in failure of normal bone breakdown. Although involved in bone remodeling, osteoclasts are of hematopoietic origin and may potentially be t

Recently, the multiplexing efficiency metric is proposed for characterizing the MIMO performance of terminal antennas. Here, we show that it can also provide useful insights into the impact of user on MIMO terminal performance. In particular, the impact of user hand and head on the efficiency and correlation of a MIMO antenna can be conveniently quantified using the multiplexing efficiency metric.

Description: Python® is a free open-source language and environment that has great potential in scientific computing. Computing with Python presents the programming language in close connection wit mathematical applications. The approach of the book is concept based rather than a systematic introduction to the language. It is written for a mathematical readership and is aimed at students with a ma

Predicting the probable survival for a patient can be very challenging for many diseases. In many forms of cancer, the choice of treatment can be directly impacted by the estimated risk for the patient. This thesis explores different methods to predict the patient's survival chances using artificial neural networks (ANN). ANN is a machine learning technique inspired by how neurons in the brain fu

Popular Abstract in Swedish Cancer i levern kan vara av två typer - antingen kan den ha sitt ursprung från levern och kallas primär levercancer eller också är den en spridning av tumör till levern från en annan plats i kroppen, s k dottersvulst eller metastas. Idag är kirurgi av tumörer i levern förstahandsbehandling, men tyvärr är det bara 1/10 patienter som har tumör i levern som kan bli aktuellLocal treatment of a tumour is of interest from a number of perspectives. It is focused on reducing the tumour volume with minimal trauma, inducing tumour immunity and is a potential component of a combination therapy against tumours. Interstitial laser thermotherapy (ILT) has turned out to be a method well suited for selective local destruction of malignant tumours. This thesis is based on an exp

Cancer har kommit att bli en av de största folksjukdomarna i den industrialiserade västvärlden och enbart i Sverige insjuknar över 55 000 personer varje år. Det faktum att var tredje person kommer att drabbas av en cancersjukdom någon gång under sin livstid innebär, förutom ett stort mänskligt lidande, att samhället står inför stora folkhälsopolitiska utmaningar att nå medborgarna med sina hälsofr

This paper presents a new method for the design of oversampled uniform DFT-filter banks for the special application of subband adaptive beamforming with microphone arrays. Since array applications rely on the fact that different source positions give rise to different signal delays, a beamformer alters the phase information of the signals. This in turn leads to signal degradations when perfect rec

Föräldrabalkens 6 kap. 2 a § stadgar att barnets bästa skall vara avgörande för alla beslut i frågor om vårdnad, boende och umgänge. Barnets bästa är en princip som går att finna i såväl internationella dokument som i nationell lagstiftning. Begreppet barnets bästas innebörd är ej uttryckligen definierad i varken de internationella dokumenten, såsom barnkonventionen, eller i svensk nationell lagstAccording to the Swedish parental code 6 chapter 2 a §, the best interest of the child shall be conclusive for all decisions in matters of custody, residency and right to access. The best interest of the child is a principle which can be found in both international documents and in national legislation. The concept of the principle of the best interest of the child is not expressly defined in neit

Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma subtype. In Sweden 450 new cases are diagnosed annually. With modern anthracycline-containing chemotherapy DLBCL is potentially curable, with an estimated overall cure rate of approximately 50% for patients with advanced stage disease. Through molecular profiling of DLBCL the ?cell-of-origin concept? has been established: patients

Vid företagsförvärv kan det finnas en önskan hos köparen att låta målbolaget medverka till finansieringen av aktieförvärvet. Möjligheterna till sådan medverkan begränsas emellertid genom det s.k. förvärvslåneförbudet i 21 kap. 5 § aktiebolagslagen (2005:551) enligt vilket aktiebolag inte får ge förskott, lämna lån eller ställa säkerhet (”lån m.m.) i syfte att gäldenären ska förvärva aktier i bolagWhen acquiring shares in a company the buyer may want the target company to contribute to the financing of the acquisition. The means of such contribution is however limited through a prohibition in Chapter 21 Section 5 of the Companies Act (2005:551) according to which a company may not grant advance, provide loans or provide security for loans (“loans etc.”) in order that the debtor or any natur

Popular Abstract in Swedish Malaria och tuberkulos är två av de mest dödliga infektionssjukdomarna i världen. Biologiskt är de två infektionerna mycket olika; malaria orsakas av en encellig parasit, en plasmodium, som sprids mellan personer med hjälp av myggbett, och tuberkulos av en bakterie som sprids via upphostade bakterier. Vidare drabbar malaria vanligtvis blodomloppet medan tuberkulos oftasMalaria and tuberculosis are two of the most deadly infectious diseases that exist. Both diseases predominantly affect the most vunerable parts of society. Additionally the treatment of both diseases are complicated by growing and spreading resistance against the drugs used to treat them. Chloroquine was once described as a wonder drug for its combination of efficacy, low price and tolerable side

The performance and reliability of wireless communications at sea are often limited by the deep fades caused by the coherent sea surface reflection. In this paper, we show that by employing multiple antennas at the base station, the deep fades can be mitigated within a large communication range if the antennas are carefully spaced in the vertical direction. We derive a bound for the range where mi

Low-dimensional parametric models are the de-facto standard in computer vision for intrinsic camera calibration. These models explicitly describe the mapping between incoming viewing rays and image pixels. In this paper, we explore an alternative approach which implicitly models the lens distortion. The main idea is to replace the parametric model with a regularization term that ensures the latent

We have compared the predictions of ligand-binding affinities from several methods based on end-point molecular dynamics simulations and continuum solvation, i.e. methods related to MM/PBSA (molecular mechanics combined with Poisson-Boltzmann and surface area solvation). Two continuum-solvation models were considered, viz. the Poisson-Boltzmann (PB) and generalised Born (GB) approaches. The non-el

Recent investigations have indicated that different solvation methods give qualitatively different results for the nonpolar solvation contribution to ligand-binding affinities. Therefore, we have calculated the nonpolar solvation contribution to the free energy of benzene binding to the T4 lysozyme Leu99Ala mutant using thermodynamic integration (TI) and three approximate methods. The total bindin

This paper presents a double directional analysis of vehicle-to-vehicle channel measurements conducted in two different traffic environments. Using a high-resolution algorithm, we derive channel parameters like angle-of- arrival, angle-of-departure, propagation delay and Doppler’s spread and identify underlying propagation mechanisms by combining these estimates with maps of the measurement sites.

With the continued development of tracking technology and increasing interest in animal movement, our understanding of migration behavior has become more comprehensive. However, there are still many species that have not been well studied, particularly sea birds. Here, we present the first year-round Global Positioning System (GPS) tracking data of the Black-tailed Gull (Larus crassirostris) at th

Pentachlorophenol (PCP) is a commonly found recalcitrant and toxic groundwater contaminant that resists degradation, bioaccumulates, and has a potential for long-range environmental transport. Taking proper actions to deal with the pollutant accounting for the life cycle consequences requires a better understanding of its behavior in the subsurface. We recognize the huge potential for enhancing de

In standard crystallographic refinement of biomacromolecules, the crystallographic raw data are supplemented by empirical restraints that ensure that the structure makes chemical sense. These restraints are typically accurate for amino acids and nucleic acids, but less so for cofactors, substrates, inhibitors, ligands and metal sites. In quantum refinement, this potential is replaced by more accur