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Negative symptoms (avolition, anhedonia, asociality, blunted affect, and alogia) are among the most disabling features of schizophrenia spectrum disorders. In the absence of treatment consensus guidelines, this PRISMA-compliant meta-analysis (PROSPERO: CRD42024613967) evaluated efficacy and clinical significance of interventions targeting this dimension. Web of Science/PsycInfo databases were sear
In recent years, climate change and the corresponding expected extreme weather conditions have been widelyrecognized as potential problems. The construction industry is taking various actions to achieve sustainabledevelopment, implement energy conservation strategies, and provide climate change mitigation. In addition tomitigation, it is crucial to adapt to climate change, and to investigate the p
As a part of our continuous search for oncogenic viruses in bronchial cancer, we extended our HPV studies to analyse also SV40, BKV, JCV and HCMV sequences in bronchial cancer and related these data with p53 codon 72 polymorphism. Fresh tumor samples from 78 patients with lung cancer were analysed for SV40, BKV, JCV, HCMV and HPV sequences by PCR. HPV genotypes were determined using reverse blot h
Background: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective: To examine the effectiveness of initiating biologics in a large, real-world cohort of adult patients with severe asthma and HOCS. Methods: This was a propensity score–matched, prospective cohort
In this master's thesis, data from eight different cases of novice entrepreneurs is gathered. The goal was to investigate how novice entrepreneurs shape their decision-making process to manage uncertainty in the early stages of their ventures. Utilizing qualitative interviews conducted between March and April of 2024, this study delves into the different strategies used by novice entrepreneurs
The purpose of this thesis is to critically examine whether China following the Third Plenary Session in December 1978 could be considered a developmental state with a focus on public bureaucracy. The research uses single case study research as its methodological approach, coupled with content analysis on secondary sources, to examine whether reforms after 1978 unfolded in a way that had tailored
Abstract – Introduction: – Severe symptoms and disability may remain after upper and lower limb nerve injuries with an additional risk of persistent pain and consumption of pain medication.Objectives: – To examine whether upper and lower limb nerve injuries, potentially causes of pain, are associated with risk of using pain medication.Methods: – Drug use at an individual level was analysed in a la
Background: Adult-onset diabetes comprises subgroups differing in pathophysiology, clinical presentation, and risk of comorbidities. We investigated early phenotypic differences between individuals who later developed diabetes, stratified by subgroup at diabetes diagnosis. Methods: We conducted a pooled analysis of nine prospective European cohorts with 3309 individuals developing incident diabete
Popular Abstract in Swedish All materia består av atomer. Avhandlingen du just nu läser är uppbyggd av atomer; till och med du själv är uppbyggd av atomer. En kemist är intresserad av vilka atomer som hänger ihop för att bilda molekyler och hur dessa molekyler kan sammanfogas till fasta material. Man kan likna det vid att molekylerna är en byggsten som då de sammanfogas bildar en byggnadskonstruktHow do molecules arrange themselves in a crystal? It is today not possible to definite predict the three-dimensional packing arrangement of molecules in the crystalline solid state. The aim of the work presented in this thesis has been to gain more knowledge of what principles that govern molecular packing. Platinum(II) complexes have been chosen as model system since these compounds are stable,
Professor Contact details Email: hakan [dot] jonson [at] soch [dot] lu [dot] se Phone: +46 46 222 12 93Organisation School of Social Work Room number: 448 Service point: 28 WebpageHåkan Jönsons profile in Lund University research portalOther affiliations Profile area member LU Profile Area: Human rights Profile area member LU Profile Area: Proactive Ageing Professor Ageing and Eldercare Publicatio
https://www.humanrights.lu.se/hakan-jonson - 2026-07-04
SummaryElevated HDL-C levels are generally regarded as prognostically favorable in cardiovascular disease. Our study shows that higher HDL cholesterol levels are prospectively associated with 18% increased risk of new-onset fractures in men but not in women. Higher HDL cholesterol may be a novel risk factor for developing fractures in men.PurposeIncreased high-density lipoprotein cholesterol (HDL-
Background Long-term pathological breathlessness is a life-limiting symptom that risks taking control of the individual’s life. We aimed to evaluate how locus of control (LOC), an individual’s perceived control of present and past life events, relates to breathlessness in a middle-aged general population. Methods A population-based, cross-sectional analysis of people aged 50–64 years was conducted
Background and objective: Although cardiovascular toxicity from modern systemic treatments in metastatic hormone-sensitive prostate cancer (mHSPC) remains a concern, real-world data are limited. We aimed to characterise patients treated for mHSPC across multiple large cohorts and estimate cardiovascular adverse event (AE) risks. Methods: Leveraging PIONEER's Big Data platform, with databases stand
Aim Postural orthostatic tachycardia syndrome (POTS) is a disorder with cardiovascular autonomic dysfunction where multiple and variable symptoms are common, including those from the peripheral and enteric nervous systems. We aimed to investigate subjective and objective signs of small and large fiber neuropathy in a Swedish POTS cohort compared with healthy controls. Secondly, we wanted to examin
Background: Alcohol intake increases recurrence of atrial fibrillation (AF), but its relationship with cardiovascular outcomes is less well characterized. We aimed to study the association between different levels of alcohol intake and cardiovascular outcomes in a global cohort of patients with AF. Methods: This is a cross-sectional analysis of the RE-LY AF registry, including 15,400 patients with
The purpose of this paper is to critically examine how older women interact, perform to their heart's content, learn music, and communicate across cultures around square dancing in a Chinese context. The paper explores how retired Chinese grandmothers use square dancing to build social interactions, find friendships and integrate into diverse group life. It also considers the identity backgrou
Since the 1950s, no other material has been developed and used to the same extent as plastic. We have built up a society that has integrated plastics into virtually every aspect of our lives. With low material prices, cheap manufacturing methods and its versatility, plastic has quickly become a commodity in society that is consumed in an unsustainable way. Plastic pollution causes immense social,
Collaborative governance is an approach used by governments to create policies in an equitable manner through the consensus seeking decision-making process via the collaboration of stakeholders that will be affected by the solution. However, one of the many critiques of this approach is that there are power imbalances between those involved, that instead make the outcome inequitable. Collaborative
