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BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved
Background: Preeclampsia is a leading cause of maternal and fetal mortality. Although antenatal care can identify women at risk, limited research has explored women's experiences with preeclampsia despite itssignificant impact.Aim: This thesis aims to enhance the understanding of women's experiences with preeclampsia in order toimprove clinical care, support, and mental health outcomes. This inclu
Despite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an
Purpose: Right ventricular (RV) dysfunction is the key prognostic factor in pulmonary arterial hypertension (PAH). Progression to RV failure involves dilatation, systolic and diastolic impairment, fibrosis, and metabolic changes. Lung transplantation (LTx) normalizes RV afterload, but the extent of recovery and its relation to immunosuppressive therapy remain unclear. We aimed to assess RV functio
Background. Traditional crash-based analysis of road safety at individual sites has its shortcomings due to low numbers and the random nature of crashes at individual sites and the related statistical issues, as well as the under-reporting of crashes and lack of information on contributing factors and the process preceding crashes. To get around the problem, road safety analysis based on surrogateAbstract Background. Traditional crash-based analysis of road safety at individual sites has its shortcomings due to low numbers and the random nature of crashes at individual sites and the related statistical issues, as well as the under-reporting of crashes and lack of information on contributing factors and the process preceding crashes. To get around the problem, road safety analysis based on
Whey protein powder functionality is expected to be closely linked to both structure and properties of the proteins. It is essential that whey protein powders are easily dispersed and dissolved in order to fulfil the specified nutrient content and the functionality in the final product. Poor rehydration can cause challenges on an industrial level as well as for the consumers. In this thesis, sever
Popular Abstract in Undetermined The transparent wings of tiny parasitic wasps and small flies are remarkably thin, only a few hundreds nanometers thick, and may appear to have a simple structural airfoil design. The thesis deals with new findings about structural color reflections and the ultrastructure of such tiny transparent wings of parasitic wasps. The main discovery is that when seemingly tThe remarkably thin transparent wing membranes in tiny wasps may appear to have a simple structural design, but hide a largely unexplored complex of micro-morphological features that serve aerodynamics and may also function in visual signaling. I found that when such small transparent wings are viewed against a dark background they display vivid structural color patterns due to thin film interfere
Spray drying is a preferred method to produce dry powder of thermally sensitive materials such as food and pharmaceuticals. Drying conditions and formulation determine primary properties such as morphology and composition that finally provide functionality such as dissolution, encapsulation and flowability. Even though spray drying is a well-established method to produce dry powder numerous challe
The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.With the intention to The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons. With the intention to
Introduction In the context of public transportation, just as in many parts of society, the level of organizational complexity has increased over the last twenty years. Due to structural reforms and policy adjustments, responsibilities for the public transportation system in Sweden have become increasingly divided between a variety of public and private actors, thus fragmenting the organizational
Fairtrade has become a familiar trademark for most consumers in the developed world and represents an option for the buyer to purchase a product that has been certified to follow the ethical standards of ”fair” trade. This branding has received much critique over the last years concerning Fairtrade's ability to improve the lives of small producers in the developing world. This thesis derives f
The aim of this master thesis is to explore which meanings that can be ascribed to knowledge organization in the field of library- and information science. This I do through studying two works that deal with this subject, namely Everything is Miscellaneous: The Power of the New Digital Disorder by David Weinberger from 2007 and Organization of Information by Arlene G. Taylor and Daniel N. Jourdrey
This essay describes different solutions for how to better regulate the market short- and long term, more cost efficiently and environmentally sustainable for emissions trading in the European Union´s trading system EU ETS. We analyse six different approaches to intervene the market. These six are; cancellation of allowances, revision of the reduction rate, backloading, extending demand, price flo
Nearly 60% of the worlds adult population is projected to be overweight or obese by 2030. The prevalence of obesity- related diseases, such as type 2 diabetes (T2D), has increased markedly in the past decades. The adipose tissue plays an important role in disease progression of T2D. Adipocyte insulin sensitivity, adipose tissue’s ability to expand, and accumulation of subcutaneous rather than visc
Since the demand on ready-to-eat (RTE) and raw, minimally processed products is high and increasing in today´s market, the microbial quality is important. One of these products is RTE salads and salads mixes that are bagged and since it is supposed to be eaten raw without any step to reduce the microbial load, these types of products are considered to be risk foods and that the risk of foodborne o
Society has become locked into an unsustainable agri-food system based on resource intensive industrial agriculture and a globalized supply chain producing food that is damaging to the environment and society. In London, United Kingdom a network of alternative food initiatives exists challenging this agri-food system and bring about a transition to one that is more sustainable. However so far the
Product integrity depends on the way the package is handled and transported; therefore packaging has a big impact on logistics, costs and efficiency along the entire distribution chain. Damaged or leaking packages are the result of an inconvenient distribution, and lead to product waste and a negative image of the brands involved. Even though Tetra Pak gives guidelines and recommendations concerni
