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Prediction of survival after pancreatoduodenectomy for distal cholangiocarcinoma : independent external validation of a prognostic model for 3-year overall survival in Sweden

Objectives: The only treatment with curative potential for distal cholangiocarcinoma (dCCA) is radical surgery which can be complemented with adjuvant chemotherapy. The aim of the present study was to perform an independent external validation of a prognostic model for 3-year overall survival based on routine clinicopathological variables for patients treated with pancreatoduodenectomy for dCCA. M

Development of serious mental illness in young adult violent offenders : Early-life risk factors and long-term adverse outcomes

This study explored serious mental illness (SMI) in young adult offenders imprisoned for violent or sexual crimes, estimating the effects of neurodevelopmental disorders and early-life risk factors on the development of SMI, and its prospective long-term adverse outcomes. An all-male cohort of 266 violent offenders, assessed during imprisonment when aged 18–25 years (M = 21.8, SD = 1.9), was follo

Effect of mechanical ventilation versus spontaneous breathing on abdominal edema and inflammation in ARDS: an experimental porcine model.

Background: Mechanical ventilation (MV), compared to spontaneous breathing (SB), has been found to increase abdominal edema and inflammation in experimental sepsis. Our hypothesis was that in primary acute respiratory distress syndrome (ARDS) MV would enhance inflammation and edema in the abdomen.Methods: Thirteen piglets were randomized into two groups (SB and MV) after the induction of ARDS by l

Assessment of drift in the Immunotechnology cell line MUTZ-3

Analys av immunteknologis MUTZ-3 visar tecken på genetisk drift Allergi är en vanligt förekommande sjukdom som drabbar en stor del av befolkningen. Sjukdomen kan ta många olika former och vanliga typer är matallergi, luftvägsallergi och kontaktallergi. Kontaktallergi uppstår när en person kommer i upprepad kontakt med kemikalier som kan aktivera immunförvaret. Immunförsvarets är ett komplext nätveThe continued increased exposure to chemicals and the increasing prevalence of allergic contact dermatitis makes it important to develop accurate testing methods and strategies to assess chemical sensitizers. The Genomic Allergen Rapid Detection (GARD) assay is an in vitro test method that uses the transcriptional response of a myeloid cell line, MUTZ-3, after exposure to test substances to assess

Value-Based Memory Integration: The Asymmetry of Loss and Reward in Episodic Memory

Memory integration is how series of similar memories can merge into overlapping representations as one abstract model of behavior to anticipate present and future episodes – facilitating instrumental use of episodic experience for higher-order inferences. Previous research has showed that a novel memory of reward can travel backwards in time through episodic memory and generalize its contents to p

Effektivisera byggbranschen med system för leveransplanering : En kartläggning av befintlig situation och fallstudier för två pilotprojekt

Problemformulering: Hur ser informationsflödet mellan leverantör och entreprenör ut och vilka icke värdeskapande aktiviteter finns idag kopplade till en bristfällig leveransplanering? Kan dessa aktiviteter reduceras med befintligt systemet eller finns önskemål att ändra eller ta fram en helt annan typ av system? Syfte: Att ge läsaren en god inblick i hur det arbetars med materialförsörjning på enProblem: This study examines problems in the Construction supply chain. Most industries have already included use of assistive technology in their daily work and I will research if it is possible to implement a system for delivery planning in the construction industry to reduce non-value adding activities. A system designed for construction delivery planning has been developed. In order to grow an

Massive MIMO Channel Modeling

Massive MIMO has attracted many researchers’ attention as it is a promising technology for future 5G communication systems. To characterize the propagation channels of the massive MIMO and to evaluate system performance, it is important to develop an accurate channel model for it. In this thesis, two correlative models, i.e., the Kronecker model and the Weichselberger model, and a cluster-based m

Isotonic regression in deterministic and random design settings

This thesis will treat the subject of constrained statistical inference and will have its focus on isotonic regression, which is the problem of estimating functions that are assumed to be monotone. A characterisation of isotonic regression and a solution to this problem will be given. The PAVA algorithm to compute the isotonic regres- sion estimator will be introduced along with asymptotic distrib

Cloning of an insulin-carrying nanocontainer in a Hepatitis B virus system

Studies of virus capsids opens up new opportunities to develop different kind of cargo systems, but also the understanding of the transportation and the releasing of different kinds of cargo molecules. Virus capsids is a protein shell of a virus that encapsulates different types of infecting nucleic acid sequences in their native forms. One of these capsids is the Hepatitis B virus capsid that in

Current voltage characterization of high-k oxide on InGaAs substrate

Abstract Metal oxide semiconductor (MOS) capacitor was fabricated on the InGaAs substrate with Al2O3/HfO2 gate oxide. InGaAs is one of the promising candidates for advanced applications which require the lower power supply and high frequency. The high-k films (Al2O3/HfO2) were formed by atomic layer deposition (ALD) as an alternative to silicon dioxide (SiO2) to proceed the scaling of oxide to low

Barnen från S:t Jakob: tolkning av socioekonomisk kontext utifrån en osteologisk analys av S:t Jakob i Lund

S:t Jacobs church and burial site from medieval Lund was excavated in 1983. There has until now not been any osteological study and there is nearly no information about the church. To gain more information about the church and the burials, an osteological study has now been made. The analysis is based on aging and sexing the skeletons to enable a socio-economic discussion. 93 out of 320 excavated

Downscaling and modelling of an ion-exchange chromatography column for purifying glucose solutions

Skalning och modellering av en kromatografikolonn för rening av sockerlösningar. För att uppnå klimatmålen behöver fossila råvaror inom kemiindustrin bytas ut mot förnybara råvaror. Socker är en råvara med stor potential inom industrin, men är ofta förorenat med salter. Därför utforskas rening av sockerlösningar här. För att använda socker som förnybar råvara för kemiindustri behöver sockret oftaTo utilize sugars as a feedstock for renewable industries, the feedstock often needs to be very pure. This is due to ionic species contaminating the sugar feedstock being potent catalyst poisons in many cases. To remove ionic species from the sugar feedstock, it is dissolved and purified using packed ion-exchange columns. In this report, a lab-scale setup of a large scale ion-exchange setup was co

Evaluation of the Potential Lactic Acid Bacteria (LAB) to Ferment Quinoa Milk

The study aimed at (a) investigated the ability of potential lactic acid bacteria (LAB) to ferment quinoa milk, and (b) formulating a method for producing fermented quinoa milk. To meet the objectives, Lactobacillus pentosus and Pediococcus pentosaceus two native bacterial strains were tested. Quinoa milk elaboration was optimized at laboratory scale by selecting an appropriate quinoa/water propor

Safety and Security in Sudan: Humanitarian Aid Workers’ Risk Perception

Protection of humanitarian aid workers (HAWs) is a challenging task. There are various reports on the topic where much research seems to focus on traditional physical attacks and intentional violence against HAWs (security) rather than the accidental event risks (safety) or discussing it separately. These risks are usually defined by the organization’s security risk management holding the power in

Onlinedejting - ”det är liksom inte svart och vitt” : En enkätstudie om olika generationers attityder till onlinedejting i Sverige

In less than two decades, online dating services have gone from being seen as a marginal and stigmatised practice, to being a regular activity in people's social and romantic lives. This thesis intends to examine Swedish attitudes towards the digital phenomena of online dating and online dating services. The study was conducted through a quantitative method in the form of an online survey, wit

Burning Questions: Community Engagement and Wildfire Management in a Changing Climate. A case study of Kamloops, British Columbia, Canada

As Climate Change increases the frequency and severity of wildfires in British Columbia, communities at the Wildland Urban Interface face escalating risks. This thesis explores the challenges and opportunities of community engagement in wildfire management in the city of Kamloops, one of the most fire-prone urban areas in British Columbia. Employing a single-case study design, the research is base