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BACKGROUND: Heart failure (HF) is a common complication to atrial fibrillation (AF), leading to rehospitalization and death. Early identification of patients with AF at risk for HF might improve outcomes. We aimed to derive a score to predict 1-year risk of new-onset HF after an emergency department (ED) visit with AF. METHODS AND RESULTS: The RE-LY AF (Randomized Evaluation of Long-Term Anticoagu
This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110 <= m(H) <= 130 GeV produced in association with a W or Z boson and decaying to b (b) over bar. Three decay channels are considered: ZH -> l(+)l(-)b (b) over bar, WH -> lvbb (b) over bar and ZH -> v (v) over bar(b) over bar where l corresponds to an electron or a muon.
Background: Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcripti
Between 1996 and 2002, 16 patients with rheumatoid arthritis and failed total ankle prosthesis underwent tibiotalocalcaneal fusion using retrograde intramedullary nails. The functional outcome was evaluated using the AOFAS scoring system and the patients were also asked about their satisfaction. Radiographs were obtained for all 16 cases minimum 1 year after surgery. Thirteen of the 16 ankles wer
The solvent shift to the fluorescence transition pi* -> n in formaldehyde in aqueous Solution is theoretically analyzed. The solvent model has explicit representation of the solvent and uses the complete active space state interaction (CASSI) method to obtain a description of the wave function of the solute similar to what the complete active space self-consistent-field (CASSCF) method would give.
Measurements of double-helicity asymmetries in inclusive hadron production in polarized p + p collisions are sensitive to helicity-dependent parton distribution functions, in particular, to the gluon helicity distribution, Delta g. This study focuses on the extraction of the double-helicity asymmetry in eta production ((p) over right arrow + (p) over right arrow -> eta + X), the eta cross section,
This article summarizes content proceedings of a symposium held at the 2004 International Society for Biomedical Research on Alcoholism Congress in Mannheim, Germany. The chairs were Boris Tabakoff and Friedrich M. Wurst. The presentations were (1) Genetic associations with alcoholism and affective disorders, by Paula Hoffman; (2) Proteomic analysis of blood constituents in alcoholism, by Boris Ta
Cellular uptake of several viruses and polybasic macromolecules requires the expression of cell-surface heparan sulfate proteoglycan (HSPG) through as yet ill-defined mechanisms. We unexpectedly found that among several cell-surface binding scFv anti-HS antibody (alphaHS) clones only one, AO4B08, efficiently translocated macromolecular cargo to intracellular vesicles through induction of HSPG endo
In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). The development of a new drug requires many studies of the c
Popular Abstract in English This thesis presents studies on moderately halophilic bacteria belonging to the family Halomonadaceae that accumulate polyhydroxybutyrate (PHB) in high amounts when grown under conditions of nitrogen limitation. PHB is the simplest homopolymer belonging to the class of polyhydroxyalkanoates (PHAs), biopolyesters that can biodegraded to carbon dioxide and water in the enThis thesis presents studies on moderately halophilic bacteria belonging to the family Halomonadaceae that accumulate polyhydroxybutyrate (PHB) in high amounts when grown under conditions of nitrogen limitation. PHB is the simplest homopolymer belonging to the class of polyhydroxyalkanoates (PHAs), the biopolyesters that can biodegraded in the environment to carbon dioxide and water and are hence
Popular Abstract in English A handful of diseases-causing pathogenic microorganisms claim millions of lives worldwide each year, mainly due to limited diagnostic capabilities. The lack of simple, cost-effective, sensitive and rapid on-site diagnostic tools lead to delays in the diagnoses with a subsequent lag in treatment, which in turn can result in serious complications or even loss of lives. Fast and sensitive detection of pathogenic microbial cells is a highly important task in medical diagnostics, environmental analysis and evaluation of food safety. Accordingly, the idea of microorganism identification by the recognition of specific DNA sequence using electrochemical technique is one of the leading researches in the development of diagnostic devices. In other words, it should only
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m(2)) compared to obese cases (BMI >= 30 Kg/m(2)). We performed two case-control genome-wide studies using two accepted cut-o
A search for heavy leptons decaying to a Z boson and an electron or a muon is presented. The search is based on pp collision data taken at root s = 8TeV by the ATLAS experiment at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb(-1). Three high-transverse-momentum electrons or muons are selected, with two of them required to be consistent with originating from a
Preclinical efficacy of continuous delivery of 3,4-dihydroxyphenylalanine (DOPA) with adeno-associated viral (AAV) vectors has recently been documented in animal models of Parkinson's disease (PD). So far, all studies have utilized a mix of two monocistronic vectors expressing either of the two genes, tyrosine hydroxylase (TH) and GTP cyclohydrolase-1 (GCH1), needed for DOPA production. Here, we p
This study investigated conceptions of decision quality and efficiency held by administrative officers from three Swedish public authorities (the Tax Board, the Social Insurance Agency, and the Police Authority) with respect to decisions made for other people. Research on conceptions of decision quality held by decision makers making decisions for themselves shows that decision outcome is emphasiz
BACKGROUND: Although it is well known that analgesics contribute to suicide, there is little knowledge about how much of the mortality and suicide can be explained by socioeconomic deprivation or by sales of analgesics. METHODS: This ecological study analyses the relationships between the sales (defined daily doses per 1000 inhabitants per day) of dextropropoxyphene, dextropropoxyphene combination
The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by addition of a transmembrane (tm) sequence, and constituti
OPENLAND3 belongs to a suite of computer programs included in the POLLSCAPE simulation model. These programs make it possible to calculate estimates of pollen loadings in lake basins or bogs using vegetation data. OPENLAND3, written in Visual Basic 6, is designed to produce appropriate vegetation data files from vegetation maps stored in a Geographical Information System. It calculates percentage
