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Effect of Calcineurin Inhibitor-Free Everolimus-Based Immunosuppressive Regimen on Albuminuria and Glomerular Filtration Rate after Heart Transplantation

BACKGROUND: Albuminuria in maintenance heart transplantation (HTx) is associated with poor renal response when switching to a calcineurin inhibitor (CNI)-lowered or free immunosuppressive regimen using everolimus (EVR), but the significance of albuminuria associated with EVR treatment after early CNI withdrawal in de novo HTx is unknown. METHODS: We tested if glomerular filtration rate (mGFR, meas

Development of an Osmium Redox Polymer Mediated Bioanode and Examination of Its Performance in Gluconobacter oxydans Based Microbial Fuel Cell

Gluconobacter oxydans (G. oxydans) cells together with an osmium redox polymer (ORP) [Osmium (2,2'-bipyridine)2(poly-vinylimidazole)10Cl]Cl were combined with a glassy carbon paste electrode (GCPE) to form a bioanode for a microbial fuel cell (MFC) based on G. oxydans. Although there are G.oxydans/ ORP combined bioanode in the literature, as far as it is known, this system is the first one where G

Knowing and Seeing the Combatant. War, Counterinsurgency and Targeting in International Law

Knowing and Seeing the Combatant investigates how does the US counterinsurgent forces make distinction between civilians and combatants during targeting practices? This dissertation is specifically focused on the visual dynamics of the contemporary targeting and as such argues that the insurgent's withdrawal from the obligation of visual self-identification as targets by not wearing military unifoKnowing and Seeing the Combatant investigates how does the US counterinsurgent forces make distinction between civilians and combatants during targeting practices? This dissertation is specifically focused on the visual dynamics of the contemporary targeting and as such argues that the insurgent's withdrawal from the obligation of visual self-identification as targets by not wearing military unifo

Recognizing Texture and Hardness by Touch

We have experimented with different neural network based architectures for bio-inspired self-organizing texture and hardness perception systems. To this end we have developed a microphone based texture sensor and a hardnesssensor that measures the compression of the material at a constant pressure.We have implemented and successfully tested both monomodal systems for texture and hardness perceptio

Development of in situ product removal strategies in biocatalysis applying scaled-down unit operations

An experimental platform based on scaled-down unit operations combined in a plug-and-play manner enables easy and highly flexible testing of advanced biocatalytic process options such as in situ product removal (ISPR) process strategies. In such a platform, it is possible to compartmentalize different process steps while operating it as a combined system, giving the possibility to test and charact

The Montreal Cognitive Assessment : Normative Data from a Large Swedish Population-Based Cohort

Background: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. Objective: To establish norms for MoCA a

Overweight, hyperglycemia and tobacco use are modifiable risk factors for onset of retinopathy 9 and 17 years after the diagnosis of diabetes – A retrospective observational nation-wide cohort study

Background The aims of this study were to estimate the risk for diabetic retinopathy (DR) and to identify risk factors. We investigated a nationwide population-based cohort with diabetes diagnosed at age 15–34 years. Patients and methods Of 794 patients registered 1987–1988 in the Diabetes Incidence Study in Sweden (DISS) 444 (56%) patients with retinal photos available for classification of retin

Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice : Relevance for Schizophrenia

BACKGROUND: Structural anomalies of white matter are found in various brain regions of patients with schizophrenia and bipolar and other psychiatric disorders, but the causes at the cellular and molecular levels remain unclear. Oxidative stress and redox dysregulation have been proposed to play a role in the pathophysiology of several psychiatric conditions, but their anatomical and functional con

Implementing the Nordic Barnahus Model : Characteristics and Local Adaptions

This chapter describes the background for, and implementation of, the Barnahus model within the Nordic countries. It highlights the core elements of the model and the specifics of the Nordic welfare state context relating to the child welfare and criminal justice systems. A contextual and comparative perspective is used to shed light on how the model is shaped by the legal and institutional contex

Breastfeeding patterns in preterm infants born at 28-33 gestational weeks

Background: Studies of breastfeeding patterns during preterm infants' first year of life are scarce but are important for providing breastfeeding mothers of preterm infants with optimal support. Objective: This study aimed to describe breastfeeding patterns in preterm infants up to 1 year of corrected age. Methods: As part of a larger study on kangaroo mother care in Sweden, a 24-hour breastfeedin

Country of residence, gender equality and victim blaming attitudes about partner violence : a multilevel analysis in EU

Background: Intimate partner violence against women (IPVAW) is a global and preventable public health problem. Public attitudes, such as victim-blaming, are important for our understanding of differences in the occurrence of IPVAW, as they contribute to its justification. In this paper, we focus on victim-blaming attitudes regarding IPVAW within the EU and we apply multilevel analyses to identify

Improved Detection of Norovirus and Hepatitis A Virus in Surface Water by Applying Pre-PCR Processing

Quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) detection of waterborne RNA viruses generally requires concentration of large water volumes due to low virus levels. A common approach is to use dead-end ultrafiltration followed by precipitation with polyethylene glycol. However, this procedure often leads to the co-concentration of PCR inhibitors that impairs the limit of det

In vivo evaluation of electron mediators for the reduction of methemoglobin encapsulated in liposomes using electron energies produced by red blood cell glycolysis

© 2017 Informa UK Limited, trading as Taylor & Francis Group Earlier studies have clarified that NADH and NADPH, re-energized repeatedly by red blood cell (RBC) glycolysis, can be used in extracellular chemical reactions, where electron energies are extracted by electron mediators, such as methylene blue (MB). The electron mediators, which are reduced by NAD(P)H, permeate both the membranes of

Seasonal-Scale Dating of a Shallow Ice Core From Greenland Using Oxygen Isotope Matching Between Data and Simulation

A precise age scale based on annual layer counting is essential for investigating past environmental changes from ice core records. However, subannual scale dating is hampered by the irregular intraannual variabilities of oxygen isotope (δ18O) records. Here we propose a dating method based on matching the δ18O variations between ice core records and records simulated by isotope-enabled climate mod

Isolated pulmonary regurgitation causes decreased right ventricular longitudinal function and compensatory increased septal pumping in a porcine model

Aim: Longitudinal ventricular contraction is a parameter of cardiac performance with predictive power. Right ventricular (RV) longitudinal function is impaired in patients with free pulmonary regurgitation (PR) following corrective surgery for Tetralogy of Fallot (TOF). It remains unclear whether this is a consequence of the surgical repair, or whether it is inherent to PR. The aim of this study w

Transient ischemic attack and ischemic stroke patients with or without prior stroke

Objectives: A history of stroke is common in patients with transient ischemic attack (TIA) and ischemic stroke (IS), but there are few reports characterizing this group of patients. We aimed to compare characteristics, risk factors, and secondary preventive treatment in patients with TIA or IS with vs without a history of stroke. Methods: Hospital-based data on TIA and IS events, registered from J

Individualised 177Lu-DOTATATE treatment of neuroendocrine tumours based on kidney dosimetry

Purpose: To present data from an interim analysis of a Phase II trial designed to determine the feasibility, safety, and efficacy of individualising treatment based on renal dosimetry, by giving as many cycles as possible within a maximum renal biologically effective dose (BED). Method: Treatment was given with repeated cycles of 7.4 GBq 177Lu-DOTATATE at 8-12-week intervals. Detailed dosimetry wa

Practical dietary calorie management, body weight control and energy expenditure of diabetic patients in short-term hospitalization

Aim: We investigated how dietary management affected body weight (BW) reduction and energy expenditure in obese and normal-weight type 2 diabetic patients. Methods: Type 2 diabetic patients who were hospitalized for diabetic control (93 men and 51 women) were checked for resting energy expenditure (REE). Subjects were divided into the two groups according to body mass index (BMI): obese (BMI ≥ 25)

IL-6 and CRP are superior in early differentiation between mild and non-mild acute pancreatitis

Background The revised Atlanta classification on acute pancreatitis (AP) presents distinct criteria for severity categorization. Due to the lack of reliable prognostic markers, a majority of patients with AP are currently hospitalized and initially managed identically. As incidence and financial costs are rising the need for early severity differentiation will increase. This study aimed to investi

Ventricular kinetic energy in young fontan patients

Introduction: Four-dimensional (4D) flow magnetic resonance imaging (MRI) enables kinetic energy (KE) quantification of intraventricular blood flow. In this study we aimed to quantify the KE in in patients with univentricular heart and to assess the change in the KE after different types of interventions. Methods: 4D flow MRI was acquired in patients with Fontan circulation (n=12; median age 12, r