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This article analyses the ethical and philosophical dimensions of preimplantation genetic diagnosis for creating saviour siblings. It evaluates the moral concerns of autonomy and instrumentalisation, while situating the debate within broader legal and philosophical frameworks of reproductive decision-making.
Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs) into mature induced neuronal (iN) cells by forced expression of three transcription factors: ASCL1, MYT1L, and BRN2. Here, we show that ASCL1 alone is sufficient to generate funct
The use of standards has permeated virtually all aspects of modern society. Standards should be seen as the combined result of the standardisers’ expertise and the effects of the dynamics of the standardisation process itself. This article explores why some participants are more influential in standards development than others. Using an insider perspective, observations are gathered from almost a
Some recent advances in high-spin physics are reviewed emphasising the role of symmetries in rotating nuclei. Evidence is presented for breaking of the axial symmetry (triaxiality) as well as of the reflection symmetry (octupole deformation). Spectroscopic consequences of shell structure in rapidly rotating nuclei with 2:1 shapes (superdeformations) are discussed.
Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs)
Background The fundamental problem with the pavement marking letter design is dealing with the phenomenon of image distortion by perspective. Because there has been a lack of a systematic way to deal with the problem on Korean pavement marking letters, the outputs have been determined by the installer's subjective design judgement. Ultimately, this causes low legibility. The purpose of this study
The paper explores what the methodological considerations are for a study of educational practice and networked learning in technologically dense classrooms. The approach of the discussed study is informed by Actor-Network Theory (ANT) (Latour, 2005) and the paper outlines the methodological consequences for adopting principles associated with ANT and post-humanist critiques of representational ep
Eye movements do more than gather visual input – they actively contribute to the formation and retrieval of relational memories by linking information across space and time. During retrieval, gaze patterns often reflect memory reactivation well before an explicit response is made, a phenomenon known as the relational eye-movement effect. While this effect appears closely associated with hippocampa
Recent years have seen an uptake in cycling and, with it, an increase in cyclists being involved in crashes. One particularly problematic area is that of urban signalised intersections, which are responsible for a majority of the crashes involving cyclists. One reason is the increased complexity at such locations. The bike box has been hailed as an infrastructure measure to help increase the safet
Transitioning towards a circular economy, where the existing building stock is more efficiently used, would significantly reduce material and energy use, emissions, and waste from the built environment sector. This study focuses on exploring what conditions are needed for circularity by imagining preferable circular futures for a 2035 timeframe and understanding the required actions to achieve the
For many years, questions about the future have been marginalised within the social sciences: asking how we might live in a post-fossil society, or what are the key decisions and events that could take us there, has been seen as outside of the disciplinary scope. In this chapter – which takes as its point of departure the ‘speculative turn’ that is increasingly inspiring a range of works, from for
Balloon borne frost-point hygrometers and backscatter sondes were launched at Sodankylä, Finland in January and February of 1996. These instruments measure water vapor and the backscatter ratio of light due to polar stratospheric clouds in the Arctic stratospheric vortex. Here we report the results of a hygrometer sonde and a backscatter sonde launched within 3.5 hours of each other on January 22/
Reactions of the primary pyridine radicals, ortho-, meta-, and para-pyridyls with oxygen control the overall rate of pyridine oxidation. In the present work, the potential energy surfaces of o-, m-, and p-pyridyls + O2 previously developed by the authors have been employed for a systematic theoretical kinetic study of the rate constants of these reactions. The geometries of reactants, products, in
Sustainable wildlife management should, amongst others, safeguard human health. This study concerns rural residents’ perceived quality of life and the potential effect of large carnivores (LCs) on psychological health outcomes (life satisfaction, anxiety symptoms, and exhaustion). One group of rural residents that appears to be especially vulnerable when the number and range of LCs increase is she
Purpose:This paper aims to contribute to the understanding of the recirculation of products by empirically exploring, conceptualising and explaining how second-hand goods are made in practices and processes of valuation.Design/methodology/approach: The paper takes a practice theory approach to valuation and draws on an ethnographic study of ReTuna, a second-hand shopping mall, to explore the valua
The skin is the outermost organ that serves as the host's live, microbiota-inhabited physical border, evolved to cope with continuous confrontation by a wide variety of environmental elements. This dynamic borderline is prone to injury and damage. Therefore, to deliver on the critical demands for protection, skin is tightly associated with innate and adaptive defense mechanisms that ensure homeost
