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During the last decade the variation in the human genome has been mapped in fine detail. Next generation sequencing has made it possible to cheaply and rapidly aquire vast amounts of biomolecular information on large cohorts of people. This have enabled large-scale epidemiological studies to investigate the relationships between environmental and genetic factors and human biomolecular traits. It i

Against the background of the ongoing shift in the perception of the legality and legitimacy of extraterritorial lethal force in counterterrorism, this thesis analyses the emergence of so-called “targeted killing” in the history of Israel and the US, as well as in international law. It finds that the relationship between targeted killing and law, particularly international law, is not a straightfo

Popular Abstract in Swedish Avhandlingen behandlar reglering av Homogeneous Charge Compression Ignition (HCCI) motor dynamik. HCCI erbjuder möjligheten att kombinera hög effektivitet med väldigt låga emissioner. Återkopplad reglering är ett sätt att uppnå dessa mål. Avhandlingen diskuterar sensorer, återkopplingsvariabler och aktuatorer för sluten-loop reglering av HCCI förbränningen. Det är demoThe topic of the thesis is control of Homogeneous Charge Compression Ignition (HCCI) engine dynamics. HCCI offers a potential to combine high efficiency with very low emissions. In order to fulfill the potential benefits, closed-loop control is needed. The thesis discusses sensors, feedback signals and actuators for closed-loop control of the HCCI combustion. Closed-loop control of the HCCI combu

This thesis aims to find algorithms for optimal control of hybrid systems and explore them in sufficient detail to be able to implement the ideas in computational tools. By hybrid systems is meant systems with interacting continuous and discrete dynamics. Code for computations has been developed in parallel to the theory. The optimal control methods studied in this thesis are global, i.e. the ent

This thesis investigates the topic of joint positioning and radio channel estimation and prediction. Both positioning and radio channel estimation have a long history of research with many publications but the combination of the two has so far at large been left unexplored. The reason for studying this topic is twofold: improvement of positioning and improvement of radio channel prediction. Positi

The topic of the thesis is codesign of flexible real-time control systems. Integrating control theory and real-time scheduling theory, it is possible to achieve higher resource utilization and better control performance. The integration requires new tools for analysis, design, and implementation. The problem of scheduling the individual parts of a control algorithm is studied. It is shown how sub

This thesis treats different aspects of automotive control-systems and consists of four papers covering different areas in this large field. The first paper presents a 9-degrees-of-freedom dynamic model of a tractor-semitrailer vehicle, aimed at simulation and evaluation of active chassis-systems for stability enhancements. Special focus is put on inclusion of the dynamics of load transfer, which

Having multiple control tasks concurrently running on a single computing platform increases the processor utilization but degrades the control performance due to delay and jitter. In scheduling and control codesign, the objective is to optimize the combined performance of all the controllers, subject to a schedulability constraint. The codesign procedure consists of selecting task parameters, e.g.

Popular Abstract in Swedish Avhandlingen består av två delar. Den första delen behandlar reglering av processer med lång dödtid. Avhandlingen ger förslag på hur regulatorer för dessa processer ska dimensioneras och jämför sedan prestanda hos dessa regulatorer med vanliga PID-regulatorer. Avhandlingens andra del handlar om metoder för automatisk övervakning av reglerkretsar i processindustrin. TvåThe thesis contains two parts, dead-time compensation and performance monitoring. The first part on dead-time compensation is about robust tuning procedures for dead-time compensating controllers (DTC). Both stable and integrating processes are considered. Simple experiments are performed to obtain process models as well as bounds on the allowable bandwidth for stability. The DTCs used have few pa

This thesis presents models and methods for feedback-based resource management for cyber-physical systems. Common for the scenarios considered are severe resource constraints, uncertain and time-varying conditions and the goal of enabling flexibility in systems design rather than restricting it. A brief survey on reservation-based scheduling, an important enabling technology for this thesis, is pr

New five-coordinate Pt(ii) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.

Popular Abstract in Swedish Personer med insulinbehandlad diabetes saknar, eller har kraftigt försämrad, kroppsegen förmåga att reglera blodsockernivån genom utsöndring av hormonet insulin, och måste därför ta flera injektioner insulin dagligen. De flesta injektioner tas i samband med måltid, och individen bestämmer normalt sina måltidsdoser utifrån aktuell blodsocker- och hälsostatus i kombinatioDiabetes is a disease characterized by insufficient capacity to regulate the blood glucose level. In insulin-dependent diabetes, multiple daily injections of insulin have to be administered. In-between scheduled visits to the care provider, the patient has to manage the glucose control independently. Insulin dosing is a non-trivial task and many patients find it difficult. This is reflected in the

The functionality of modern automotive vehicles is becoming increasingly dependent on control systems. Active safety is an area in which control systems play a pivotal role. Currently, rule-based control algorithms are widespread throughout the automotive industry. In order to improve performance and reduce development time, model-based methods may be employed. The primary contribution of this the

Popular Abstract in Swedish Avhandlingen Optimization of Low-Level Controllers and High-Level Polymer Grade Changes är inom ämnesområdet reglerteknik. Det centrala i ämnet reglerteknik är att styra ett system, såsom en motor, ett teleskop eller en kemisk reaktor, så att det uppför sig på ett önskvärt sätt. Detta görs genom att använda mätningar av systemet, en algoritm som beräknar hur systemet sTwo design problems at different levels in the control hierarchy are considered; optimization of robust low-level controllers with constrained control signal activity and optimization of economical high-level polyethylene grade changes. As for the first design problem, a constraint on control signal activity due to measurement noise is presented and used when optimizing and comparing PI/PID contr

Popular Abstract in Undetermined I den här populärvetenskapliga sammanfattningen berörs avhandlingen Gradient Methods for Large-Scale and Distributed Linear Quadratic Control. Hur kan jetflygplan hålla sig i luften? Hur kan en Segway balansera en människa? Dessa frågor och många fler kan besvaras med hjälp av reglerteknik. Reglerteknik är ett område som behandlar hur man automatiskt styr system oThis thesis considers methods for synthesis of linear quadratic controllers for large-scale, interconnected systems. Conventional methods that solve the linear quadratic control problem are only applicable to systems with moderate size, due to the rapid increase in both computational time and memory requirements as the system size increases. The methods presented in this thesis show a much slower