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Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease. Expression of properdin by monocytes was examined in type I deficiency and in two unrelated cases with type II deficiency, one from a Swedish and one from a Da
Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 ca
Many of society’s critical infrastructures, such as power supply, telecommunications, and transportation, have become increasingly interconnected. While this gives rise to increased efficiency, tighter connections also invites increased vulnerability and the risks of cascading failures. Moreover, at the same time as many of these vital systems have become increasingly dependent on one another, the
Dendritic cells (DC) are a heterogeneous lineage of bone-marrow-derived leukocytes that serve as the link between innate and adaptive immunity. They are professional antigen-presenting cells that play an important protective and regulatory role in both health and disease. This thesis is based upon six original papers that deal with the function and transcription of human DCs, with focus on their r
Self-tuning control of the dissolved oxygen concentration has been tested in full scale at the Käppala Sewage Works at Lidingö, Sweden. The controller has been shown to be robust during varying operating conditions. It also gives the potential for the estimation of interesting variables, such as the oxygen uptake rate. A number of water quality variables have been examined. Interesting couplings b
Popular Abstract in Swedish Upptäckten av Helicobacter pylori (Hp) (1982) har revolutionerat synen på uppkomsten av såväl magsår, magkatarr som magsäckskancer. Idag vet vi att Hp är en mycket starkt bidragande orsak till samtliga dessa sjukdomar och är en av våra vanligaste sjukdomsframkallande bakterier. Epidemiologiska studier har visat att mellan 50 och 80% av jordens befolkning är smittad. I SHelicobacter pylori and Borrelia burgdorferi s.l. can cause chronic infections by evading the immune system. These two human pathogens express a number of immunogenic cell surface proteins. The aims of this study were to gain further knowledge about these antigens and to analyse the serum antibody response in infected individuals. Both invasive and non-invasive diagnostic methods are available for
This paper develops a control integration methodology that can be used to balance competing performance objectives. The target application for the method is blood glucose management for diabetic patients. The true system model is uncertain and changes over time. Multiple controllers have been designed with competing performance objectives in mind. In the proposed method, on-line predictors are use
Elevated moisture contents due to exposed weather conditions and ageing façade materials can often lead to degradation and increased risks for the building walls, but also affect the insulating properties of the materials, as thermal and hygric behaviour of building materials are closely interconnected. This paper presents the first results from a study of a 1950-ies multi-family building with a p
Chromosome abnormalities, in particular translocations, and gene fusions are hallmarks of neoplasia. Although both have been recognized as important drivers of cancer for decades, our knowledge of the characterizing features of the cytobands involved in recombinations is poorly understood. The present study, based on a comparative analysis of 10 442 translocation breakpoints and 30 762 gene fusion
COVID-19 is a serious threat to human health and development. The acute burden of the pandemic includes more than 18.2 million deaths worldwide, and is unprecedented in modern times. This represents only a fraction of the total burden, as it excludes infection sequelae. An effective global strategic paradigm has been missing throughout the pandemic. The ‘flattening the curve’ approach neglected th
Myxoid liposarcoma (MLS) is molecularly characterized by fusions involving the DDIT3 gene in chromosome band 12q13; the fusion partner is FUS in band 16p11 in 90–95% of the cases and EWSR1 in band 22q12 in the remaining 5–10%. Hence, molecular studies, often fluorescence in situ hybridization (FISH) for DDIT3 rearrangement, are useful for establishing a correct diagnosis. Although all MLS tumors s
Abstract in Thaiชาวจีนจำนวนมากเดินทางเข้ามายังเดลี-เมดานในช่วงศตวรรษที่ 19 ในฐานะแรงงานสัญญาจ้างเพื่อพัฒนาเขตเกษตรกรรมของดัตช์บนเกาะสุมาตราโดยเฉพาะบริเวณตะวันออกของสุมาตราเหนือครอบคลุมพื้นที่ของเดลี เซอดัง (Deli-Serdang) และเมืองเมดาน (Medan) ในปัจจุบัน พื้นที่ดังกล่าวถูกพัฒนาขึ้นให้กลายเป็นพื้นที่เกษตรกรรมสมัยใหม่ มีการเพาะปลูกพืชหลายชนิด โดยพืชเศรษฐกิจที่สำคัญที่สุดในพื้นที่ขณะนั้น คือ ใบยาสูบ ซIn the 19th Century, Deli-Medan received a large number of Chinese migrants. Most of them worked as labourers in Dutch agricultural plantations on the east coast of Sumatra, extending from Deli-Serdang to Medan. The agricultural products, such as tobacco, were intentionally developed and eventually became the most exportedproducts of Sumatra. As these economic a
BackgroundChildren and youth who experience divorce are found to have increased risk of emotional and behavioural adjustment problems. Different prevention programmes have been developed to help and support children. Previous studies have focused on the child or the group leader's experience with divorce groups, but studies describing parent's experience are missing. The aim of this study was to e
Structural Health Monitoring (SHM) plays a vital role in maintaining the integrity of structures by providing continuous information about damage or anomalies. Vibration-based SHM, which focuses on the dynamic behavior of structures, offers insights into structural conditions through changes in dynamic properties. Among SHM approaches, damage localization is crucial for pinpointing the geometric l
Wynes and Nicholas (2017a Environ. Res. Lett. 12 1-9) recently published an article that reviewed academic and grey literature to identify the most impactful individual actions for reducing carbon emissions in developed countries, identifying having 'one fewer child' as by far the most impactful action. This action was recommended with little context considering its controversial nature. We argue
Popular Abstract in Swedish Synd och skam. Ogifta mödrar på svensk landsbygd, 1680-1880. Avhandlingens utgångspunkt har varit ogifta mödrar på svensk landsbygd i ett långtidsperspektiv, 1680-1880. Arbetet är kvinnohistoriskt och utgår från en önskan att synliggöra betydelsen av kön i det äldre samhället. Hur tänkte och resonerade man kring kön och sexualitet i det förindustriella bondesamhället? The situation of unmarried mothers in Swedish rural society during 1680–1880 is the subject of this thesis. It focuses on the judicial and religious discourse concerning extra-marital sexuality. The state felt duty-bound to control extra-marital sexuality, and this resulted in a dynamic legislative arena. An important objective has been to study the local consequences of legislative changes and ex
Enzymes carrying NlpC/p60 domains, for instance RipA and RipB from Mycobacterium tuberculosis, are bacterial peptidoglycan hydrolases that cleave the peptide stems and contribute to cellwall remodelling during cell division.Amember of this protein family, RipD (Rv1566c) from M. tuberculosis described in the present study, displays sequence alterations in the NlpC/p60 catalytic triad and carries a
A quantitative understanding of the hydro-environmental factors that influence the occurrence of agricultural drought events would enable more strategic climate change adaptation and drought management plans. Practical drought hazard mapping remains challenging due to possible exclusion of the most pertinent drought drivers, and to the use of inadequate predictive models that cannot describe droug
