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Although a causative role of α-synuclein (α-syn) is well established in Parkinson’s disease pathogenesis, available animal models of synucleinopathy do not replicate the full range of cellular and behavioral changes characteristic of the human disease. This study was designed to generate a more faithful model of Parkinson’s disease by injecting human α-syn fibril seeds into the rat substantia nigr
PURPOSE: To examine the cytokine profile of epithelial cells lining the human urinary tract with the aim of differentiating between the constitutive and disease-related cytokine production in these tissues.MATERIALS AND METHODS: Sections from the renal pelvis, ureter, bladder or urethra were obtained from 22 patients undergoing urinary tract surgery and were stained with monoclonal antibodies to i
In 2009 the Democratic Party of Japan came to power with a new foreign policy tailored to the regional and global power shift from the United States to China: a more equal relationship with the United States and improved relations with Japan’s Asian neighbours. Within nine months the new Prime Minister Hatoyama Yukio resigned and the foreign policy shift was jettisoned by his successors. Conventio
Microcredit schemes have been increasingly incorporated into development policiesthat aim to de-marginalise rural China. Based on in-depth ethnographicfieldwork,this paper examines the various roles that microcredit programmes play indevelopment outcomes at the local level. It demonstrates that microcredit has theability to facilitate the de-marginalisation of certain individuals/
The voluminous literature on industrial catching-up in Southeast Asian countries has regularly argued that successful catching-up largely depended on a committed state, which orchestrated industry development with a relatively uniform set of policies, including R&D support, subsidies, trade restrictions, and local content requirements. In contrast, recent contributions from the technology life
In the post 9/11 era the effort to strengthen democracy in weak and fragile states has become a common undertaking of prominent international actors in their foreign policy agendas. In much of the academic and policy discourse democracy assistance has been framed as a solution to political instability and under-development in troubled states. With the case of the Middle East and North Africa regio
Urban theory has historically situated ethnic commercial strips as an organic extension of nearby ethnic residential enclaving. While this is still a useful way to frame such commercial spaces in many cities, this article argues that some areas of this sort function as a marketable branding mechanism (intended or not) to produce nearby residential gentrification. This article explores the influenc
To investigate associations between economic stress in childhood and adulthood, and lack of internal health locus of control (HLC), testing the accumulation and critical period life course hypotheses. Methods: A cross-sectional public health (postal) survey was conducted in Skåne in 2008, based on a random sample with 28,198 participants in the age interval 18-80 years, with 55% participation. Log
Peak oil has acquired prominence in the political lexicon of an increasing number of critical and radical perspectives during the ongoing ecological and economic crisis. By examining examples within academia as well as initiatives such as the Degrowth Movement and the Transition Network, this paper documents how a series of red-green discourses and movements mobilise the narrative of peak oil as a
National renewable energy action plans (NREAPs) required as part of the EU Directive on renewable energy include various biomass elements. The call for mandatory NREAPs represents a substantial shift of focus from the earlier call for optional national biomass action plans (BAPs). Biomass strategies and action plans are considered to form a vital part of the renewable energy plans. This study exam
We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified thr
Throughout history, scientific advancement hasbeen dependent upon advances in the technologies ofresearch. However, branches of research that today relyon Research Infrastructures (RIs) such as acceleratorsrequire technological investments so large that multinationcollaborations are required to fund them. Modernaccelerator science also has massive (and increasing)energy needs, yet the very provisi
The aim of this thesis was to evaluate long-term outcomes in a regional cohort of adolescents born extremely preterm (before the 29th gestational week) and compare them to full-term born controls. Fifty-two prematurely and 54 full-term born individuals were recruited from a follow-up study at 10 years of age. The participant rate was 85 % from the prematurely born group and 89 % from the full-term
Objectives. The association between materialist, mixed and post-materialist values, and the experience of cannabis smoking among young adults was investigated. Methods. The 2004 public health survey in Skane, southern Sweden, is a cross-sectional study with a 59% response rate. The 6787 persons aged 18-34 years included in this study answered a postal questionnaire. A logistic regression model was
Background : Legal empowerment of the poor is highly relevant to public health as it aims to relieve income poverty, a main determinant of health. The Commission on Legal Empowerment of the Poor (CLEP) has proposed legal empowerment measures in the following four domains: access to justice and the rule of law, property, labor, and business rights. Despite being overrepresented among the poor, CLEP
Mental health problems among adolescents have become a major public health issue, and it is therefore important to increase knowledge on the contextual determinants of adolescent mental health. One such determinant is the socioeconomic structure of the neighbourhood. The present study has two central objectives, (i) to examine if neighbourhood socioeconomic deprivation is associated to individual
