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Human papillomavirus type 16 (HPV-16) 5'-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 late 5'-splice site SD3632. Two AUAGUA motifs located in these 34 nt inhibited SD3632. Two nucleotide substitutions in each of the HPV-16 specific AUAGUA motifs alleviated splicing inhibition and induced l
Chronic pulmonary disease is a recognized risk factor for invasive pneumococcal disease (IPD). However, previous studies have often not been large enough to allow detailed analyses of less prevalent pulmonary diseases, and findings regarding case fatality have been inconsistent. We examined the associations between an underlying pulmonary disease and IPD, and the impact of these diseases on the ca
The article examines the reception of Old Testament motifs in the so called "Hymn of the Pearl" (preserved in Syriac and Greek as part of the apocryphal Acts of Thomas). Ideas taken up for study include the use of "Egypt" as a symbol of spiritual bondage, the legacy of the West Semitic Chaoskampf motif, the link to Ezekiel 32:2, etc. The main thrust of the article is the transformation of ancient
BACKGROUND: Lead time, the estimated time by which screening advances the date of diagnosis, is used to calculate the risk of overdiagnosis. We sought to describe empirically the distribution of lead times between an elevated prostate-specific antigen (PSA) and subsequent prostate cancer diagnosis. METHODS: We linked the Swedish cancer registry to two independent cohorts: 60-year-olds sampled in 1
Aims Genetic testing is needed for the formal diagnosis of maturity-onset diabetes of the young (MODY), but this is not widely available. If any MODY biomarkers were known, these could possibly be used as an alternative. Hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha regulate transcription of genes encoding complement 5 (C5), complement 8 (C8) and transthyretin (TTR), suggesting that these
Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of w
Autologous dermal fibroblasts may be useful in the treatment of diabetic skin wounds. We hypothesized that cultured fibroblasts or cultured keratinocytes would not only survive in a hyperglycemic wound environment but also enhance the rate of re-epithelialization. We previously developed a new porcine model of delayed cutaneous wound healing in the diabetic pig. Full thickness wounds were created
AIMS: Tilt testing (TT) is recognized to be a valuable contribution to the diagnosis and the pathophysiology of vasovagal syncope (VVS). This study aimed to assess the influence of age on TT responses by examination of a large patient cohort.METHODS AND RESULTS: Retrospective data from three experienced European Syncope Units were merged to include 5236 patients investigated for suspected VVS by t
Enterprise Resource Planning (ERP) systems have become a fundamental part of business infrastructure. In an effort to minimize the risk associated with ERP implementation, a number of critical success factors (CSFs) have been developed. However, CSFs are presented as independent from context, under the pretense that all ERP implementations are equal. In this study, we challenged this assumption by
Immunotherapy, which involves strategies to activate, enhance or redirect immune responses to achieve long-lasting immunity, has the potential to play an important role in the treatment of a variety of diseases. This thesis, based on four original papers, highlights different approaches to modulate immune responses by specific targeting of antigen-presenting cells. The first two studies focuses o
Microsoft Word - DRAFT 3 Master’s thesis Landscape planning from a child’s perspective A case study in the Vombsänkan in southernmost Sweden Lund, 25 May 2009 Lund University Master’s Programme in Environmental Studies and Sustainability Science “LUMES” Submitted by: Mirjam van der Hoek mirjamvanderhoek@hotmail.com Supervised by: Göran Ewald goran.ewald@lucsus.lu.se 2 Abstract Landscapes are mostl
https://www.lumes.lu.se/sites/lumes.lu.se/files/vanderhoek_mirjam_0.pdf - 2026-06-26
1 Analysis of the Espoo Convention as applied to mega projects: The case of Nord Stream. by Francisco M. Hernández pinescu@hotmail.com Thesis supervisor: Dr. Aleh Cherp International Institute for Industrial Environmental Economics, Lund University. aleh.cherp@mespom.eu A Thesis Submitted to Lunds Universitet in partial fulfilment of the requirements for the degree of MASTER OF SCIENCE Lund Univer
https://www.lumes.lu.se/sites/lumes.lu.se/files/francisco_hernandez.pdf - 2026-06-26
Accessible design enables participation in the digital society for everyone. However, cognitive accessibility is not well established within the field of web design. The International Classification of Functioning, Disability and Health (ICF) provides a descriptive framework that relates health conditions to functioning and participation. ICF Core Sets are purposefully tailored shortlists of ICF c
The normal flora furnishes the host with ecological barriers that prevent pathogen attack while maintaining tissue homeostasis. Urinary tract infections (UTIs) constitute a highly relevant model of microbial adaptation in which some patients infected with Escherichia coil develop acute pyelonephritis, while other patients with bacteriuria exhibit an asymptomatic carrier state similar to bacterial
Objective: It is important to understand levels and social inequalities in childhood overweight within and between countries. This study examined prevalence and social inequality in adolescent overweight in 35 countries, and associations with macroeconomic factors. Design: International cross-sectional survey in national samples of schools. Subjects: A total of 11-, 13- and 15-year-olds from 35 co
The ambition in this thesis is to try out an alternative language for music didaktik relations during music activity in preschool settings. The aim of the study is to describe and to analyze the didaktiks in music activity in preschool settings. The aim of the study is also on research basis to try out concepts that denote and capture the figuration of music activity. The overall research question
