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The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'im
BACKGROUND: Vascular endothelial dysfunction, accelerated thickening of arterial intima, and changes in ventricular repolarization contribute to increased cardiovascular morbidity in type 1 diabetes (T1D). Although vitamin C has important antioxidant functions and increased oxidative stress is a central mechanism of cardiovascular dysfunction in T1D, the relation between vitamin C and the cardiova
This paper describes differences between the capacity of Swedish and Danish students to attain life quality. This was carried out by examining the level of competence in four different groups of Swedish and Danish students, and is based on the hypothesis that the possession of competence is a premise for the development of life quality. Competence means the ability to make sense in complex situati
A chapter on societal, individual and socioeconomic consequences of long term unemployment and unfinished education among marginalised youth.
The interaction between DNA and cationic cosolutes- multivalent ions, cationic surfactants and cationic macromolecules- has direct biological implications and is also foreseen to have a number of applications, in particular for transfection and protection and purification of DNA. We have during the last few years established a broad physico-chemical research program on various mixed systems of DNA
Essä om Exorcisten (1973) - publikmottagandet, filmkritiken och eftermälet samt om den nya Director's Cut-versionen som fick biopremiär 2001.
Orthostatic hypotension (OH) is a common cardiovascular disorder, with or without signs of underlying neurodegenerative disease. OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/diastolic blood pressure decrease of at least 20/10 mm Hg upon standing. Its prevalence is age dependent, ranging from 5% in patients <50 years of age to 30% in those >70 years of
Solar energy conversion into electricity by photovoltaic modules is now a mature technology. We discuss the need for materials and device developments using conventional silicon and other materials, pointing to the need to use scalable materials and to reduce the energy payback time. Storage of solar energy can be achieved using the energy of light to produce a fuel. We discuss how this can be ach
One billion vulnerable subsistence farmers across the global south depend on risky livelihoods in need of adaptation to climate change impacts. Simultaneously, their aggregated emission of greenhouse gases from land use and fuelwood consumption is substantial. Synergies between adaptation to climate change and mitigation should therefore be actively promoted. In the context of poverty, such synerg
Evaluation of: Akada J, Kamei S, Ito A et al. A new type of protein chip to detect hepatocellular carcinoma-related autoimmune antibodies in the sera of hepatitis C virus-positive patients. Proteome Sci. 11(1), 33 (2013). Unlocking the proteome and delivering biomarkers to the clinic will be critical for early and improved diagnosis and prognosis. Conventional protein microarrays have evolved as a
Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and
Animal models greatly facilitate understanding of transmission, pathogenesis and immune responses in HIV and SIV infection and provide models for studies on the effect of candidate drugs or vaccines. However, there are several aspects that one should consider when drawing conclusions from results obtained from animal models. First, the genetic relationship of primate lentiviruses cannot be disrega
Objective: To analyze surgical complications after primary cleft palate repair in a setting with limited resources. Patients and Design: A total of 1608 consecutive cleft palate repairs with 1408 follow-ups, operated upon between 2011 and 2013, were reviewed retrospectively through medical records. Patients were 10 months to 50 years old at the time of surgery, with a median age of 9 years. Settin
