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OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams

Sammanfattning: Uppsatsen består av två kvantitativa beräkningar gjorda i sex grammatikböcker ur kurslitteraturen vid Institutionen för nordiska språk, LU. Den första beräkningen utgörs av antalet subjekt i exempelmeningarna med manlig respektive kvinnlig referent. Den andra beräkningen utgörs av de semantiska roller som dessa subjekt innehar i exempelmeningarna. Syftet är att utröna om män repre

The report, designed for interested parties of the industrial food industry in France, is founded on three research questions inspired by literature studies of sustainable development, management of corporate social responsibility, industrial food production and food product quality. The research questions search for the identification and explanation of critical categories of concern relevant for

Tissue clearing allows 3D-imaging of large biomedical samples, but can be affected by blur effects limiting individual cells detection. Using a structured illumination light sheet we solve this issue, obtaining high-contrast images in turbid samples.

Is there beauty in rhetorical failure? This study is an exploration of disorder and death in the Gospel according to Mark (Mk). With a surviving fragment from the second-century theologian Papias of Hierapolis, the early reception of Mk locates insights into the composition of Jesus’s death, especially through the concepts of ataxia and rhetorical failure. Papias launches an early and influential

Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections. Among these, complete C1s deficiency has been reported in nine cases so far. Here, we describe a 34-year-old male patient who presented with severe, recurrent infections since childhood, includ

Library and information science (LIS), is a research area marked by theoretical diversity and strong influence from both the developing library profession, as well as other social sciences. During the development of LIS several attempts have been made to define its scientific identity. The definition of what constitutes core, boundaries and the superior identity of LIS is still debated among resea

År 2021 reformerades lagstiftningen gällande barns rätt att komma till tals i frågor om vårdnad, boende och umgänge. I 6 kap. föräldrabalken tillkom 2 b § som stadgar att barnet ska få information och ges möjlighet att framföra sina åsikter i frågor om vårdnad, boende och umgänge. Barnets åsikter ska tillmätas betydelse i förhållande till barnets ålder och mognad. Detta är den rättsliga utgångspunIn 2021, the legislation regarding children’s right to be heard in matters of custody, residence and visitation was reformed. In chapter 6 of the Children and Parents Code, section 2 b was added which stipulates that the child must receive information and be given the opportunity to express their opinions in matters of custody, residence and visitation. The child’s opinions must be given importanc

The subject of this paper concerns propaganda, articulated in the daily press and various publications, debating questions of the Swedish public libraries, library politics and the library act that was enforced in January 1997. It is a discourse analysis, focusing on the ideological, emotional and political viewpoints of writers representing the interests of the public libraries, which aims to stu

Traditional phase scan method for cavity phase and amplitude setting is offline and hard to track the variations of environment and operation points. An alternative beam loading based calibration method is investigated in this paper, which might become useful online/real time calibration method.

Feminisation of the HIV/AIDS epidemic in sub-Saharan Africa is an important public health concern. Therefore, it is crucial that we understand the various risk factors that shape unsafe sexual behaviours among young people in Uganda. The overall aim of this thesis was to gain a deeper understanding of the various factors that have an association with risky sexual behaviours among Ugandan universit

Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mec

IMPORTANCE The introduction of biological tumor necrosis factor inhibitors has improved the treatment of rheumatoid arthritis (RA) but at a substantial cost. These drugs have been shown to lead to superior radiological outcomes compared with a combination of conventional disease-modifying antirheumatic drugs over 2 years. OBJECTIVE To investigate whether radiological superiority translates into be

BACKGROUND: The role of sleeping problems in the causal pathway between job strain and musculoskeletal pain is not clear. Purpose: To investigate the impact of sleeping problems and job strain on the one-year risk for neck, shoulder, and lumbar pain. METHOD: A prospective study, using self-administered questionnaires, of a healthy cohort of 4,140 vocationally active persons ages 45-64, residing in

The use of service oriented architectures (SOA) is rapidly penetrating contemporary business life based on the promise of scalable and flexible information infrastructures. However the technique is still in it infancy and many questions regarding the consequences of a shift towards this kind of IT architecture still remains unanswered. We approach the relation between SOA and another actual topic,

It is the aim of this thesis to contribute to a research-based understanding of researchers’ use of blogs as a part of scholarly communication. The following research questions guide the investigation: (1) How are scholarly blogs constructed and used as sociotechnical systems in scholarly communication? (2) Which roles do scholarly blogs play in relation to other forms of scholarly communicati

The growing complexity of integrated circuits and increasing component density place higher requirements for raw material and clean room standards, which demand significant amounts of energy. In spite of these developments, semiconductor facilities managed to reduce their energy intensity measured per product unit. At the same time, the impact of increasing circuit integration on upstream life cyc

Structural Health Information (SHI) may be provided by various sources such as e.g. structural health monitoring, inspections, testing and digital technologies and networks as by the Industry Internet of Things (HOT). SHI holds a high potential for industrial, life safety and sustainability value and facilitates an optimal and intelligent life cycle management of infrastructure and machinery syste

There is widespread agreement on the many benefits citizens gain from recreational use of local green spaces such as urban woodlands, and the importance of involving users in the development of their everyday landscapes. Despite this, the impact of userparticipation on the quality of public green spaces has not been thoroughly studied. In this PhD thesis, resident participation in public urban woo