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The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. ER export was facilitated by addition of a transmembrane (tm) sequence, and constituti
In this study, a plant-wide model describing the fate of C, N and P compounds, upgraded to account for (on-site/off-site) greenhouse gas (GHG) emissions, was implemented within the International Water Association (IWA) Benchmarking Simulation Model No. 2 (BSM2) framework. The proposed approach includes the main biological N2O production pathways and mechanistically describes CO2 (biogenic/non-biog
1 ENERGY SECURITY IN EUROPE Proceedings from the conference “Energy Security in Europe” Lund 24-25 September 2007 Edited by: Bo Petersson Barbara Törnquist-Plewa CFE Conference Papers Series No. 2 Lund 2008 The CFE Conference papers series is published by The Centre for European Studies (CFE) at Lund University: © 2008 The Centre for European Studies at Lund University and the authors Editors: Bo
https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfecp2.pdf - 2026-06-28
We develop a procedure for exploring the free energy landscape of protein-peptide binding at atomic detail and apply it to PDZ domain-peptide interactions. The procedure involves soft constraints on receptor proteins providing limited chain flexibility, including backbone motions. Peptide chains are left fully flexible and kept in spatial proximity of the protein through periodic boundary conditio
Integration of Multijunction Absorbers and Catalysts for Efficient Solar‐Driven Artificial Leaf Structures: A Physical and Materials Science Perspective Integration of Multijunction Absorbers and Catalysts for Efficient Solar-Driven Artificial Leaf Structures: A Physical and Materials Science Perspective Thomas Hannappel,* Sahar Shekarabi, Wolfram Jaegermann, Erich Runge, Jan Philipp Hofmann, Roel
https://www.nano.lu.se/sites/nano.lu.se/files/2026-04/Solar%20RRL%20-%202024%20-%20Hannappel.pdf - 2026-06-28
The emission composition is measured for a prototype burner while varying the equivalence ratio in discrete portions of the burner. The burner is a three sector system, consisting of a separate igniter, pilot/stabilizer and main burner. The design allows for discrete control of equivalence ratio in each of the three sectors. The ignition sector, designated RPL (Rich- Pilot-Lean), operates from ric
An academic 12-lead electrocardiogram (ECG) core laboratory aims to provide the highest possible quality ECG recording, measurement, and storage to aid clinicians in research into important cardiovascular outcomes and to maximize the credibility of scientific results based solely, or in part, on ECG data. This position paper presents a guide for the structure and function of an academic ECG core l
Advancement of aqueous zinc-ion batteries (AZIBs) for practical application is limited due to the inferior performance of the existing cathode. Herein, we demonstrate rational design and synthesis of an oxygen vacancy-rich low-valent vanadium-based spinel cathode (OV-ZnV2O4) for the fabrication of high-performance AZIBs. ZnV2O4 having an urchin-like morphology with nanorods ∼19 nm in diameter
We have examined the effect of geometry optimisation on energies calculated with the quantum-mechanical (QM) cluster, the combined QM and molecular-mechanics (QM/MM), the big-QM approaches (very large single-point QM calculations taken from QM/MM-optimised structures, including all atoms within 4.5 Å of the minimal active site, all buried charged groups in the protein, and truncations moved at lea
Grid connected renewable energy systems are becoming popular due to reasons such as rapid escalation of energy prices, depletion of fossil fuel resources and pollutant emitted by conventional energy sources. Therefore, technologies for incorporating renewable energy technologies into the existing electricity grid needs to be researched more considering the changes in grid architecture. This study
Determination of the atomic structure of solid surfaces typically depends on comparison of measured properties with simulations based on hypothesized structural models. For simple structures, the models may be guessed, but for more complex structures there is a need for reliable theory-based search algorithms. So far, such methods have been limited by the combinatorial complexity and computational
