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Although the direction of loads applied to the proximal human femur is unpredictable during sideways fall, most in vitro and numerical simulations refer to a single loading condition (15° internal rotation; 10° adduction), which has been anecdotally suggested in the 1950s. The aim of the present study was to improve in vitro simulations of sideways falls on the proximal femur. An in vitro setup w
AIMS: Cancer syndromes manifest at many sites albeit with variable penetrance. Genome-wide association (GWA) studies have identified susceptibility loci shared by many types of cancer. Yet, a population level search for shared susceptibility between discordant cancers has been hampered because of lacking population sizes. METHODS: Over 1.1million patients in the nation-wide Swedish Family-Cancer D
BACKGROUND: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer.METHODS AND FINDINGS: We identified genetic instruments for potential metabolic risk factors and eval
MicroRNAs are small single stranded RNA molecules containing approximately 22 nucleotides and these play an important regulatory role in gene expression. MicroRNAs are found to be involved in several diseases and knowledge about their sequences can be an important tool in the foundation of novel treatment methods against diseases. Today, these small RNA molecules are mainly analyzed with qPCR and
General Purpose Graphics Processing Units (GPGPUs) have become the prevalent processor for AI/ML and other large computational problems because parallel processing has not reached a hardware limit, unlike single-threaded processing. The goal of the thesis is to investigate the suitability of a novel SRAM architecture for implementation in a GPU without extensive GPU architecture changes. This arch
As the latest generation of wireless access technology called Fifth Generation (5G) New Radio (NR) evolves, computational efficiency is key to keep low cost and flexible deployments for vendors. Understanding how the Digital Signal Processing (DSP) load behaves in the digital units is one aspect to enable this efficiency. This thesis investigates how the DSP load in the base station behaves for a
When particles are dispersed in a microfluidic device, its resonant frequencies can be used to manipulate their positions at will. This practice, called acoustophoresis, has been shown to successfully control multiple particles simultaneously with a single vibrating actuator, which is a low-cost and contactless alternative to existing particle manipulation methods, and whose applications include i
Extracellular vesicles (EVs) in biofluids are heterogeneous in origin, surface protein expression, and biomolecular cargo. Isolation of specific EV subpopulations may enable studies of biomarkers originating from specific cell phenotypes and disease states. Acoustic trapping is a rapid, automatable EV isolation technique requiring minimal sample preprocessing; however, it lacks the specificity nee
Proton exchange membranes (PEMs) are critical to the performance of vanadium redox flow batteries (VRFBs). Still, conventional perfluorosulfonic acid membranes such as Nafion® suffer from poor ion selectivity and limited long-term stability. In this study, we introduce PEMs prepared from four types of poly(arylene perfluorobenzenesulfonic acid)s, synthesized via polyhydroxyalkylations of biphenyl
Future mobile platforms will contain an increased amount of wireless technologies. As technologies mature it will be necessary to find synergies between them. This could be in the form of reusing hardware blocks and algorithms. By using Fast Fourier Transforms (FFT/IFFT) and performing channel cancellation/equalization in frequency domain for wideband code division multiple access (WCDMA) will pro
5003 Dynamisk simulering för att förbättra hanteringen av järnvägsstörningar Ove Hagelstedt Division of Risk Management and Societal Safety Lund University, Sweden Riskhantering och samhällssäkerhet Lunds tekniska högskola Lunds universitet Report 5003, Lund 2015 II III Dynamisk simulering för att förbättra hanteringen av järnvägsstör
https://www.cencip.lu.se/sites/cencip.lu.se/files/hagelstedt_2015.pdf - 2026-07-22
Science Journals — AAAS García-Calzón et al., Sci. Transl. Med. 12, eaaz1803 (2020) 16 September 2020 S C I E N C E T R A N S L A T I O N A L M E D I C I N E | R E S E A R C H A R T I C L E 1 of 13 M E T A B O L I S M Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes Sonia García-Calzón1,2*, Alexander Perfilyev1, Mats Martinell3, Mont
https://www.ludc.lu.se/sites/ludc.lu.se/files/fulltext.pdf - 2026-07-22
The neutron-rich N = 126 nucleus Au-205 has been populated following the relativistic energy projectile fragmentation of E/A = 1 GeV Pb-208, and studied via charged-particle decay spectroscopy. An internal decay with a transition energy of 907(5) keV and a half-life of T-1/2 = 6(2) s has been identified through the observation of the corresponding K and L internal conversion electron lines. The 90
Objectives To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the disease. Methods Linkage disequilibrium (LD) mapping was conducted by using 1251 SNPs (single nucleotide polymorphism) covering a 862 kb genomic region on 3p14.3 comprising the PXK locus in 1467 SLE patients and 2377 controls of Euro
Transmitted drug resistance (TDR) is a clinical and epidemiological problem because it may contribute to failure of antiretroviral treatment. The prevalence of TDR varies geographically, and its prevalence in Sweden during the last decade has not been reported. Plasma samples from 1,463 patients newly diagnosed with HIV-1 infection between 2003 and 2010, representing 44% of all patients diagnosed
Background: Acetyl Coenzyme A carboxylase beta (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine wheth
Due to their unique optical properties, III-V nanowires are promising candidates for the development of efficient solar cells, LEDs and nanoscaled lasers. The interaction of nanowires with fluorescent molecules is also of interest, as these nanostructures can act as nanoscaled optical fibers. The light emitted by a fluorophore close to a nanowire surface can in fact couple into the supported waveg
Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognized by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inherit
Cytogenetic analysis using Giemsa banding technique was successful in 30 of the 49 adult patients with nonHodgkin lymphomas investigated. The results are correlated with previous findings in 48 non‐Hodgkin lymphoma patients studied by means of fine needle aspiration in our laboratory. As 8 patients were included in both series, the total number successfully investigated was 70. The success rate wi
