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Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central role in DNA repair, a mechanism that is particularly instrumental in safeguarding cells against tumorigenesis. We hypothesized that polymorphisms that alte
Bradykinin (BK) and des-Arg(9)-BK are pro-inflammatory mediators acting via B2 (B2R) and B1 (B1R) receptors, respectively. We investigated the role of B2R and B1R in lipopolysaccharide (LPS)-induced hypothalamopituitary-adrenal (HPA) axis activation in SD rats. LPS given intraperitoneally (ip) up-regulated B1R mRNA in the hypothalamus, both B1R and B2R were up-regulated in pituitary and adrenal gl
Recent evidence suggests that the breast and ovarian cancer susceptibility gene product BRCA1 is involved in at least two fundamental cellular processes: transcriptional regulation and DNA repair. However, the mechanism of action of BRCA1 in either of these processes is still unknown. Here, we report the characterization of a disease-predisposing allele of BRCA1, identified in a family with severa
Professor Contact details Email: mats [dot] benner [at] fek [dot] lu [dot] se Phone: +46 46 222 76 20 Mobile: +46 72 543 49 39Organisation Research Policy Room number: Alfa2:4066 Service point: 10 WebpageMats Benners profile in Lund University research portalOther affiliations Professor CIRCLE Publications Displaying of publications. Sorted by year, then title. Filter by type AllAnthology (editor)
https://www.lusem.lu.se/mats-benner - 2026-10-04
Doctoral student Contact details Email: mi [dot] lennhag [at] svet [dot] lu [dot] se Phone: +46 70 950 93 23 Mobile: +46 70 950 93 23Organisation Department of Political Science Room number: 435 Service point: 31 WebpageMi Lennhags profile in Lund University research portalPolitical ScienceResearch and areas of interestThe Post-Soviet region and other states in Eastern and Central Europe (politics
https://www.svet.lu.se/en/mi-lennhag - 2026-10-04
Rapid changes in bird community composition at multiple temporal and spatial scales in response to recent climate change 313 Rapid changes in bird community composition at multiple temporal and spatial scales in response to recent climate change Å ke Lindstr ö m , Martin Green , G ö ran Paulson , Henrik G. Smith and Vincent Devictor Å . Lindstr ö m (ake.lindstrom@biol.lu.se), M. Green and H. G. Sm
https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-1462013lindstromcti.pdf - 2026-10-05
Professor Contact details Email: else [dot] lytken [at] fysik [dot] lu [dot] se Phone: +46 46 222 30 60 Mobile: +46 70 344 33 10Organisation Particle and nuclear physics Room number: K319 Service point: 14 WebpageElse Lytkens profile in Lund University research portalOther affiliations Head of department Department of Physics Project manager Particle and nuclear physics Senior lecturer Particle an
https://www.particle-nuclear.lu.se/else-lytken - 2026-10-04
The development of new therapies for the treatment of type 2 diabetes requires robust, reproducible and well validated in vivo experimental systems. Mice provide the most ideal animal model for studies of potential therapies. Unlike larger animals, mice have a short gestational period, are genetically similar, often give birth to many offspring at once and can be housed as multiple groups in a sin
Mutations in the gene encoding laminin α2 chain, an extracellular matrix protein mainly expressed in the neuromuscular system, cause a severe form of muscular dystrophy, congenital muscular dystrophy type 1A (MDC1A). Laminin α2 chain is associated to the muscle fibers by two major receptors, where one of them, integrin α7β1, is diminished upon laminin α2 chain deficiency. The majority of the skele
Popular Abstract in Swedish Insekter kommunicerar med dofter. De artspecifika kemiska substanser som används mellan individer kallas feromoner. Hos sädesbroddflyet, Agrotis segetum, producerar honan en "parfym", ett sexualferomon som består av flera komponenter, för att locka till sig en hane. På hanens antenner finns lukthår med särskilda motagare, receptorer, som används för att detektera honans
This study has observed and investigated random telegraph noise in the photoluminescence from InAs quantum dots in GaAs and InP quantum dots in GaInP. The dots are grown by the Stranski-Krastanow technique with a sufficiently low surface density that individual dots easily could be investigated. The luminescence from many single quantum dots, exhibiting switching between two levels, has been spect
The ternary Zintl phase Ca3Ag1+xGe3x (x = 1/3) was synthesized by the high-temperature solid-state technique and its crystal structure was refined from single-crystal diffraction data. The compound Ca3Ag1.32Ge2.68(1) adopts the Sc3NiSi3 type structure, crystal data: space group C2/m, a = 10.813(1) angstrom, b = 4.5346(4) angstrom, c = 14.3391(7) angstrom, beta = 110.05(1)degrees and V = 660.48(10)
Aim: In this study, we employed chimeric human/ mouse Proteinase 3 ( PR3) proteins as tools to induce an autoantibody response to PR3 in rats and mice. Method: Rats and mice were immunised with recombinant human PR3 ( HPR3), recombinant murine PR3 ( mPR3), single chimeric human/ mouse PR3 ( HHm, HmH, mHH, mmH, mHm, Hmm) or pools of chimeric proteins. Antibodies to mPR3 and HPR3 were measured by EL
In situ high-energy surface X-ray diffraction was employed to determine the surface structure dynamics of a Pd(100) single crystal surface acting as a model catalyst to promote CO oxidation. The measurements were performed under semirealistic conditions, i.e., 100 mbar total gas pressure and 600 K sample temperature. The surface structure was studied in detail both in a steady gas flow and in a gr
untitled Copyright 2013 American Medical Association. All rights reserved. Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease Two Case Reports Zinovia Kefalopoulou, MD, PhD; Marios Politis, MD, PhD; Paola Piccini, MD, PhD, FRCP; Niccolo Mencacci, MD; Kailash Bhatia, MD, PhD; Marjan Jahanshahi, PhD; Håkan Widner, MD, PhD; Stig Rehncrona, MD, PhD; Patrik Brundin, MD, PhD;
https://www.wnc.lu.se/sites/wnc.lu.se/files/kefalopoulou_jama_neurol.pdf - 2026-10-05
The white light LEDs of today are usually based on a blue LED and a phosphor, converting the blue light to longer wavelengths. While these phosphor-converted LEDs are extremely efficient compared to incandescent light or fluorescent light, there is still plenty of room for improvement. In the conversion between blue light and light of lower energy approximately 25-45 % of the radiant power is lost
Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector HUMAN GENE THERAPY 15:934–944 (October 2004) © Mary Ann Liebert, Inc. Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector BILJANA GEORGIEVSKA,* JOHAN JAKOBSSON,* ELISABETH PERSSON, CEC
PowerPoint-presentation Klimatmodellerna bakom IPCC-rapporterna Hur kan vi veta på vilket sätt som klimatet kommer att förändras och vilka konsekvenser det får? Paul Miller, Mgeo, LUNDS UNIVERSITET SFO:n MERGE & BECC, Profilområdet ”Nature-based Future solutions” Framtida klimatförändringar i Skåne? Beräkningar Observationer Kalla år/varma år Beräknad förändring av medeltemperatur i Skåne län unde
1 Gastrointestinal infections modulate the risk for insulin autoantibodies as the first-appearing autoantibody in the TEDDY Study Short Running Title: GI infections modulate autoantibody-risk Maria Lönnrot MD PhD1, Kristian F. Lynch PhD2, Marian Rewers MD PhD3, Åke Lernmark PhD4 Kendra Vehik PhD2, Beena Akolkar PhD5, William Hagopian MD PhD6, Jeffrey Krischer PhD2, Rickhard A. McIndoe PhD7, Jorma
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-12/155_MP22b_Lonnrot_Diab%20Care_2023_Accepted%20version.pdf - 2026-10-05
