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Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.Design: Prospective cohort study.Setting: The M

The main objective was to locate QTL and estimate the proportion of total genetic variance attributable to quantitative trait loci (QTL) for production index traits and the udder health index identified on six Bos taurus autosomes in the Danish Holstein dairy cattle population. Data were obtained from a granddaughter design of 20 sire families with a total of 1 869 progeny tested sons. The number

Phytoplankton and epiphyton often compete with submerged macrophytes. Grazing by zooplankton and/or epiphyton grazers should promote an indirect positive effect on submerged macrophyte growth rate. Hence, we mimicked shallow lakes conditions in mesocosms using a factorial design to evaluate the indirect effects of no grazers, zooplankton, snails or both grazers on macrophyte growth attributes. Aft

In the beginning of the public career of Jesus, Mark and Matthew both narrate how Jesus “calls” four fishermen to follow him which results in an immediate positive response (Mark 1:16–20/Matt 4:18–22). How is the reader to understand Jesus’ calling of disciples? Is Jesus making an authoritative command or does he merely invites the fishermen? What is Jesus doing when he “calls” his disciples? ThesIn the beginning of the public career of Jesus, Mark and Matthew both narrate how Jesus “calls” four fishermen to follow him which results in an immediate positive response (Mark 1:16–20/Matt 4:18–22). How is the reader to understand Jesus’ calling of disciples? Is Jesus making an authoritative command or does he merely invites the fishermen? What is Jesus doing when he “calls” his disciples? Thes

BACKGROUND: The Child Health Services in Sweden is a well-attended health promoting setting, and thereby has an important role in promoting healthy living habits in families with young children. Due to lack of national recommendations for health dialogues, a Child Centred Health Dialogue (CCHD) model was developed and tested in two Swedish municipalities. The aim of this study was to explore paren

Purpose: This paper demonstrates how #50+ fashion Instagram influencers contribute to the social construction of cognitive age through their aesthetic digital labours. Design/methodology/approach: Non-participative netnography was used in the form of visual and textual analysis of over 300 Instagram posts including images, captions and comments. Findings: Findings reveal how outfit selection, back

Type 2 diabetes mellitus is associated with an elevated risk of cardiovascular disease, but the mechanism through which diabetes contributes to cardiovascular disease development remains incompletely understood. In this study, we compared the association of circulating regulatory T cells, naïve T cells, effector memory T cells or central memory T cells with cardiovascular disease in patients with

Type 1 (T1D) and type 2 (T2D) diabetes are triggered by a combination of environmental and/or genetic factors. Maf transcription factors regulate pancreatic beta (β)-cell function, and have also been implicated in the regulation of immunomodulatory cytokines like interferon-β (IFNβ1). In this study, we assessed MAFA and MAFB co-expression with pro-inflammatory cytokine signaling genes in RNA-seq d

The transdisciplinary argument in this article is that the social and ecological unsustainability of modern, globalized capitalism ultimately derives from the design of its central artifact: what Polanyi called all- or general-purpose money. The notion of a singular measure of economic value is a peculiar cultural conception that is inherently at odds with physical reality, yet it pervades modern

Ambient pressure x-ray photoelectron spectroscopy (APXPS) can provide a compelling platform for studying an analyte's oxidation and reduction reactions in solutions. This paper presents proof-of-principle operando measurements of a model organometallic complex, iron hexacyanide, in an aqueous solution using the dip-and-pull technique. The data demonstrates that the electrochemically active liquid

Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African,

Purpose: Crisis planning and improvements to business resilience are increasingly significant aspects of hotel management. This study investigates the crisis preparation of hotel managers in Malaysia and how their perceptions affect crisis planning and preparation. Design/methodology/approach: A qualitative research method of semi-structured interviews with 24 hospitality managers in Malaysia was

People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic d

Background: Atherosclerotic plaque ruptures, triggered by blood flow–associated biomechanical forces, cause most myocardial infarctions and strokes. Objectives: This study aims to investigate the exact location and underlying mechanisms of atherosclerotic plaque ruptures, identifying therapeutic targets against cardiovascular events. Methods: Histology, electron microscopy, bulk and spatial RNA se