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Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not been repli-cated in the Diabetes Prevention Program (DPP). To as-sess pharmacogenetic interactions in prediabetes, we conducted a genome-wide association study (GWAS) in the DPP. Cox proportional hazards models tested associations with diabetes incidence in the metformin (MET; n = 876) and placebo (P
Atmospheric aerosols are a highly complex and dynamic mixture of solid particles, liquid deplots and gases. They travel across the continents and affect global climate and human health in various ways, often negatively. One important aspect of research in atmospheric aerosols is the investigation of emissions to the atmosphere from various sources. Emission markers are compounds unique to their so
The utilisation of biomass instead of fossil resources is an important alternative for the transition into a sustainable society. Biomass, owing to its primary constituents—cellulose, hemicelluloses and lignin—has the potential to replace many products that are produced from fossil resources today, including plastics, textile fibres and fuels. To fully exploit this potential, all of the components
Extracts from different body parts of adult female Eriocrania cicatricella (Zett.) were tested for electrophysiological activity on conspecific male antennae. Extracts from the Vth abdominal segment, containing a pair of exocrine glands, elicited the largest electroantennographic response when compared to extracts of other body parts. Female extracts were analyzed by gas chromatography with simult
Previous studies have suggested that amplification of genes, notably the TOP2A gene, on chromosome arm 17q may be important for the development of malignant peripheral nerve sheath tumour (MPNST). In order to study the frequency, distribution, and chromosomal organization of rearrangements at 17q, interphase and metaphase fluorescence in situ hybridization (FISH) were used to evaluate copy number
PURPOSE: Human epidermal growth factor receptor 2 (HER2) gene amplification or protein overexpression (HER2 positivity) defines a clinically challenging subgroup of patients with breast cancer (BC) with variable prognosis and response to therapy. We aimed to investigate the heterogeneous biologic appearance and clinical behavior of HER2-positive tumors using molecular profiling. PATIENTS AND METHO
Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype block tagged by rs1885988 and used CRISPR-Cas9 to edit the potential functional variants to confirm
Nationalparker utgör ett centralt element i naturvård runt hela jorden. Utöver naturvård så utgör tron på deras positiva effekt för regionalekonomisk utveckling en allt vanligare motivering för att grunda nya nationalparker. Forskningsläget kring omfattningen av sådana effekter är dock oklart och den ekonomiska effekten av nationalparker i Syd-, Väst, och Mellansverige har inte analyserats i någonNational parks are key parts of worldwide conservation initiatives. Increasingly, they are being founded not only to meet conservation goals but also because of their potential positive impact on regional economies. However, the results of previous research are ambiguous when it comes to assessing the magnitude of this effect and no such studies have been conducted for national parks in southern,
Antibiotic persistence arises when a subset of cells in an otherwise susceptible bacterial population temporarily exhibits elevated tolerance to bactericidal antibiotics. While significant progress has been made in elucidating persister mechanisms, much of this research has focused on Gram-negative bacteria, and these findings are not always applicable to Gram-positive species. This study explores
Register your physical attendance at the event via this form. We will confirm your physical attendance no later than 19th October. When: 20th October, 12.45 - 14.00 Where: Birgit Rausing venue, Skissernas museum, Finngatan 2, Lund. The event will also be live-streamed on Lund University's Youtube channel. When you send in this webform to Lund University, we process your personal data in accordance
https://www.lu.se/formular/registration-physical-attendance-event-max-iv-and-ess-engines-breakthrough-science - 2026-07-08
Få nya perspektiv eller fördjupa din kunskap och ta fler högskolepoäng. X-kurser är korta, flexibla och poänggivande och du kan läsa dem parallellt med din huvudutbildning. Nu kan du genom att läsa x-kurser få möjligheten att komplettera din utbildning med nya perspektiv och kunskaper. Kurserna är särskilt utformade för att passa dig som redan studerar eftersom de är: kortaflexiblages på plats, på
https://www.lu.se/student/x-kurser - 2026-07-08
Human cystatin C (hCC) is a cysteine proteinase inhibitor involved in pathophysiological processes of dimerization and amyloid formation. These processes are directly associated with a number of neurodegenerative disorders such as Alzheimer disease or hereditary cystatin C amyloid angiopathy (HCCAA). One of the ideas on how to prevent amyloid formation is to use immunotherapy. HCC3 is one of a gro
