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Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well a
The identification of genes underlying quantitative-trait loci (QTL) for complex diseases, such as rheumatoid arthritis, is a challenging and difficult task for the human genome project. Through positional cloning of the Pia4 QTL in rats, we found that a naturally occurring polymorphism of Ncf1 (encoding neutrophil cytosolic factor 1, a component of the NADPH oxidase complex) regulates arthritis s
Parametric models of a one-dimensional heat diffusion process are determined using the maximum likelihood method. The process is a linear, infinite dimensional system. Statistical teats indicate that the appropriate orders of the models obtained are relatively low. It is found empirically that successive terms in the modal expansion of the transfer function of the process, having gain factors of t
Abstract Background. Traditional crash-based analysis of road safety at individual sites has its shortcomings due to low numbers and the random nature of crashes at individual sites and the related statistical issues, as well as the under-reporting of crashes and lack of information on contributing factors and the process preceding crashes. To get around the problem, road safety analysis based on
This paper presents a combined experiment and identification procedure, well suited to obtain low-order dynamic models of a patients’ response to continuous drug administration. The experiment requires no a priori information and is of very short duration. The identification method provides both a parametric low-order model, and an estimate of the parameter error covariance. It has been demonstrat
17 december 2026 13:15 till 14:30 | Seminarium Join us for a excitning seminar with Masoumeh Mirsafah More details about time and venue will be announced soon.Coffee, tea and pastries are served after each seminar.Everyone is warmly welcome! Om evenemangetPlats:CMES seminar room, Finngatan 16.Kontakt:lisa [dot] strombom [at] svet [dot] lu [dot] se Spara evenemanget till din kalender
17 december 2026 13:15 till 14:30 | Seminarium Join us for a excitning seminar with Masoumeh Mirsafah More details about time and venue will be announced soon.Coffee, tea and pastries are served after each seminar.Everyone is warmly welcome! Om evenemangetPlats:CMES seminar room, Finngatan 16.Kontakt:lisa [dot] strombom [at] svet [dot] lu [dot] se Spara evenemanget till din kalender
This chapter explores the history of emblems, which appear on a broad spectrum between printed literature, visual art, and material culture. Starting from Andrea Alciato’s Emblematum liber of 1531, the chapter explores multiple approaches on how emblems can be understood in the context of other multimodal media types such as insignia, badges, epigrams, hieroglyphs, and visual artifacts. Differenti
The advantages of performing neutron-tagging measurements using a waveform digitizer are explored. An existing analog setup consisting of modular crate electronics at the Source-Testing Facility at the Division of Nuclear Physics in Lund, Sweden has been digitally replicated. Neutrons are detected using an organic liquid-scintillator detector while the corresponding 4.44 MeV gamma-rays are detecte
An extreme example of nonrandom rearrangements, especially inversion breaks, is described in the polytene chromosomes of the black fly Simulium bergi Rubtsov, 1956 from Armenia and Turkey. A total of 48 rearrangements was discovered, relative to the standard banding sequence for the subgenus Simulium Latreille, 1802. One rearrangement, an inversion (IIS-C) in the short arm of the second chromosome
