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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 193321 sökträffar

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The presence of solid particles in a Newtonian liquid flow will affect the properties of the flow. For small particles these effects are fairly well understood. However, the behaviour of liquids laden with large particles are less well understood and even more so if the carrier liquid is a non-Newtonian fluid. In the present study we consider large particles of spherical shape. By large is here me

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At the Museum of World Culture (former Etnografiska Museet i Göteborg) there is an archaeological collection from the Santa Maria and Calchaqui Valleys of north-western Argentina, which came to the museum in 1930. In this article we will focus on six well-preserved objects with provenience from Quilmes and La Quebrada del Carmen in the Santa Maria Valley. In addition to the good conservation of th

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In this article, I examine the development of journalism in Vietnam by exploring documentation from two media aid projects carried out by the Swedish International Development Cooperation Agency (Sida) from 1993 until 2007. The project documents contain fieldnotes, evaluations and reflections from the trainers who were recruited from Swedish media houses to conduct training in Vietnam. A qualitati

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“Lambatha” is the Greek word for celebratory candles used during Easter, christenings, and marriage ceremonies. Lambathas are elaborately decorated, often homemade pieces of folk art, but they are also made and sold commercially, either on a handicraft basis or, increasingly, by international toy franchise companies. Lambathas often feature a decorated candle and a small toy for the children. Home

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Black carbon (BC), spheroidal carbonaceous particles (SCP), and polycyclic aromatic hydrocarbons (PAH) are carbonaceous pollutants affecting the climate, environment, and human health. International regulations limit their emissions, and the present emissions are followed by monitoring programs. However, the monitoring programs have limited spatio-temporal coverage and only span the last decades.

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This thesis addresses infections in prostate biopsy – a global problem. Over 3 million prostate biopsies are performed annually and 3% of men suffer a severe infection. The risk of infection is increasing in parallel with rising antibiotic resistance. By combining clinical knowledge with technical development, this thesis aims to address the risk of infection in a novel way – by redesigning the me

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• AimsThis research investigates how different ways of referring to anthropogenic climate change produce different sensory and affective perceptions of nature in an urban destination, and how such perceptions sustain or resist the branding strategy of such place. In doing so, it aims at showing that strategic climate communication works not only rhetorically at the level of representation, but als

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The development of mesencephalic dopamine neurons and their survival later in life requires the continuous presence of the transcription factor Nurr1 (NR4A2). Nurr1 belongs to the nuclear receptors superfamily. However, it is an orphan member that does not require a ligand to regulate the transcription of its target genes. Therefore, controlling the expression of Nurr1 is an important manner to co

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We are an international collective of Early Career Academics (ECAs) who met throughout 2020 to explore the implications of COVID-19 on precarious academics. With this intervention, our aims are to voice commonly shared experiences and concerns and to reflect on the extent to which the pandemic offers opportunities to redefine Higher Education and research institutions, in a context of ongoing prec

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Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion diseases to dementias, but are also encountered in several functional contexts. Yet, the fundamental links between protein assembly mechanisms and their functional or pathological roles have remained elusive. Here, we analyze the aggregation kinetics of a large set of proteins that self-assemble by a nucleated-gr

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The refusal to shake hands with a female reporter by a Muslim politician from the Miljöpartiet resulted in a controversy in Sweden. Together with a number of court cases, it revealed a disparity between the established judicial line and the views of the general public. The Swedish controversy received a response from Denmark, where the ruling coalition introduced new citizenship legislation with a

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Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.

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Autoimmune thrombocytopenic purpura (AITP) is a bleeding disease in which autoantibodies are directed against the individual's own platelets, resulting in enhanced Fc-mediated platelet destruction by macrophages in the reticuloendothelial system. Most research in AITP has focused on characterization of the autoantibodies, while little has been devoted to the cellular immune mechanisms leading to a

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Recent evidence suggests that targeting S100A9 reduces pathological inflammation in abdominal sepsis. Herein, we investigated the role of S100A9 in neutrophil extracellular trap (NET) formation in septic lung damage. NETs were detected by electron microscopy in the lung and by confocal microscopy in vitro. Stimulation of isolated mouse bone marrow-derived neutrophils with S100A9 triggered formatio

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The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal m

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Electrodeposition of metals in templates of nano-porous anodic aluminum oxide (NP-AAO) is a versatile way of fabricating ordered arrays of metal nanowires. Thanks to the self-arranged long-range hexagonal order of the pores, electrodeposition in NP-AAO is an easily scalable bottom-up synthesis route and an attractive alternative to traditional top-down fabrication methods such as electron beam lit

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Background The National Comprehensive Cancer Network and American Urological Association guidelines on early detection of prostate cancer recommend biopsy on the basis of high prostate-specific antigen (PSA) velocity, even in the absence of other indications such as an elevated PSA or a positive digital rectal exam (DRE). Methods To evaluate the current guideline, we compared the area under the cu