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Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question:
Background: Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden. Methods: Women with history of immigration from TB-endemic countries were eligibl
Recent years have witnessed an explosion of interest in understanding the role of conformational dynamics both in the evolution of new enzymatic activities from existing enzymes and in facilitating the emergence of enzymatic activity de novo on scaffolds that were previously non-catalytic. There are also an increasing number of examples in the literature of targeted engineering of conformational d
BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H
The evolution of legal philosophy in Sweden in the first half of the 20th century basically coincides with the history of the so-called Uppsala School, which will be treated extensively in Tome 2 of this volume, in the part devoted to legal realism. Here I will be dealing with Swedish legal philosophy after that period, from the early 1940s onward, when the hitherto dominant influence of the philo
We determined the concentration of markers in cartilage and synovium metabolism in the synovial fluid (SF) of the knee of young beagle dogs with slowly progressive osteoarthrosis. Osteoarthrosis (OA) was induced by a tibial 30°valgus osteotomy to the right hindlimb of 16 dogs. The contralateral knee served as control. The animals were killed 7 (group I) and 18 months (group II) after operation. Th
Primary care in several countries is developing towards team-based and multi-professional care, requiring leadership and management capabilities at the primary care practice level. This article reports findings from a study of primary care managers in Sweden, focusing variation in performance and perceptions of feedback messages and goal-clarity, depending on managers’ professional background.
Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS pat
This study develops a framework for spatiotemporal modeling of dust storm source susceptibility in a critical case study, the Tigris-Euphrates River Basin, as a significant source of dust storms in the Middle East. The study period was divided into four periods, 2000–2004 (hydrological dry year), 2005–2007 (hydrological wet year), 2008–2012 (hydrological dry year), and 2013–2021 (hydrological wet
This chapter analyzes the legitimizing discourse of the humanities in two different public debates in Sweden at the end of the twentieth century and at the beginning of the twenty-first century. The first debate concerned the marginalized role of the humanities and their relation to the broader public, while the second was strongly influenced by current research policies, which had a strong focus
Stable carbon isotope curves derived from Lower Triassic carbonate rocks from three Iranian sections are established to investigate changes in the carbon cycle during the Early Triassic in this area. The sections are located in the south-center (Abadeh), north (Amol), and northwest (Zal) of Iran. All three curves show a similar pattern starting out with high δ13C values in the uppermost Permian de
OBJECTIVE: Glomerular filtration rate (GFR) is generally accepted as the best overall index of renal function. Thus, all potential live kidney donors are tested to ensure that they have a normal GFR before they are eligible for kidney transplantation. The choice of GFR test is very much dependent on local traditions and may include iohexol, 51Cr-EDTA, inulin, or creatinine clearance based on urine
Background and Purpose Plaque rupture is the underlying cause of most cardiovascular events, such as stroke and myocardial infarction. The co-stimulatory molecule LIGHT (tumor necrosis factor superfamily member 14, TNFSF14) has been detected in foam cell-rich regions of atherosclerotic plaques, but whether it has a role in plaque stability is not known. This study investigates the association betw
OBJECTIVES: Asphalt is frequently used as road pavement and consists of bitumen as a binder, and fillers. Bitumen consists of a complex mixture of hydrocarbons, where a minor component is polycyclic aromatic hydrocarbons (PAHs). Many PAHs are classified as carcinogenic to humans. Bitumen fumes from road paving have been classified as possibly carcinogenic. Paving and milling are open processes gen
