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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 192561 sökträffar

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A striking feature of the discourses surrounding the negotiations of Economic Partnership Agreements between the EU and developing states is the starkly contrasting pictures given of the role and nature of the EU. The Union is either portrayed as an angel, an actor with altruistic objectives, concerned primarily with the economic and social development of the ACP countries, or as a demon, an actor

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Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing cancer. New technologies to induce antigen selective l

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Several articles within the area of green chemistry often promote new techniques or products as 'green' or 'more environmentally benign' than their conventional counterpart although these articles often do not quantitatively assess the environmental performance. In order to do this, life cycle assessment (LCA) is a valuable methodology. However, on the planning stage, a full-scale LCA is considere

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The Orange Carotenoid Protein (OCP) is a photoactive water soluble protein that is crucial for photoprotection in cyanobacteria. When activated by blue-green light, it triggers quenching of phycobilisome fluorescence and regulates energy flow from the phycobilisome to the reaction center. The OCP contains a single pigment, the carotenoid 3'-hydroxyechinenone (hECN). Binding to the OCP causes a con

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The incidence of atherosclerosis is significantly increased in rheumatoid arthritis (RA). Infection is one factor that may be involved in the pathogenesis of both diseases. The cause of RA and atherosclerosis is unknown, and infection is one of the factors that may be involved in the pathogenesis of both diseases. The aims of this study were to identify bacteria in the aortic adventitia of patient

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Lead has negative effect on cognitive functions in children. However, individuals differ in susceptibility. One possible explanation is a genetic predisposition. Polymorphisms in the B-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity, but information regarding the central nervous system is very limited. The aim of the study

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Isotropic diffusion weighting is employed in diffusion NMR and MRI for rapid determination of the trace of the diffusion tensor and for showing the presence of microscopic diffusion anisotropy in a globally isotropic material. In the recently introduced q-MAS PGSE sequence, short gradient pulses define the beginning and the end of the diffusion time by quickly increasing and reducing the magnitude

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This study was designed to investigate attitudes to and incentive for reporting adverse drug reactions (ADRs) in general and towards nurses as reporters of ADRs in particular in a sample of hospital physicians. A questionnaire was sent to 1,201 randomly selected hospital physicians. The main factors for the decision to report an ADR were the severity of the reaction, a reaction to a new drug, and

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Context. Atomic data is crucial for astrophysical investigations. To understand the formation and evolution of stars, we need to analyse their observed spectra. Analysing a spectrum of a star requires information about the properties of atomic lines, such as wavelengths and oscillator strengths. However, atomic data of some elements are scarce, particularly in the infrared region, and this paper i

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Amorphous Silica (ASi) is present in considerable amounts in most soils and serves as a (micro-)nutrient for many plants. However, our understanding of the response of this important nutrient pool to human or natural disturbances is still very limited. One of the reasons for this is the long time scales involved. This explorative study focuses on the effect of a historical agricultural system, cal

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The study of electron motion in semiconductor billiards has elucidated our understanding of quantum interference and quantum chaos. The central assumption is that ionized donors generate only minor perturbations to the electron trajectories, which are determined by scattering from billiard walls. We use magnetoconductance fluctuations as a probe of the quantum interference and show that these fluc

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The vast majority of species within the lanternshark genus Etmopterus harbour complex luminescent markings on their flanks, whose functional significance has long remained obscure. Recent studies, however, suggest these enigmatic photophore aggregations to play a role in intraspecific communication. Using visual modelling based on in vivo luminescence measurements from a common lanternshark specie

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We report on the production of inclusive gamma(1S) and gamma(2S) in p-Pb collisions at root S-NN = 5.02 TeV at the LHC. The measurement is performed with the ALICE detector at backward (-4.46 < ycms < 2.96) and forward (2.03 < ycms <3.53) rapidity down to zero transverse momentum. The production cross sections of the gamma(1S) and gamma(2S) are presented, as well as the nuclear modification factor

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How are social movements of the underdogs sustained and how are constraints of these movements overcome, in particular, constraints imposed by non-liberal democratic states? Utilizing the Damansara Save Our School movement in Malaysia as its case study, this article describes factors that led to the successful resistance of the Damansara New Village community against the closure of its community s

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The study investigated 2 aspects of the accuracy (i.e., realism) of confidence judgments of persons age 60-93 years (N = 1,384) regarding their answers to general knowledge questions. These aspects are the level of confidence (calibration) in relation to the proportion of correct answers and the ability to discriminate between correct and incorrect answers by means of confidence judgments. No age

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Fire accidents and evacuation experiments have revealed that people often use familiar exits in fire emergencies. However, the design of emergency exits has also been shown to impact people’s choice of exit. In the present research, the use of flashing lights to direct people to emergency exits is explored in a series of experiments in both buildings and road tunnels. Recommendations concerning ho

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Popular Abstract in Swedish Glatt muskulatur finns i mag-tarm kanalen, i blodkärl, i luftvägarna och i flera av urogenital organen och dess funktion på alla dessa platser är att förkorta sig och generera kraft. Så styrs t.ex. blodtrycket av sammandragning i artärer och vener och transporten av föda genom mag-tarm kanalen av rytmiska kontraktioner. Det är känt att koncentrationen av fritt kalcium iThe relationship between intracellular free calcium ([Ca2+]i) and force in smooth muscle was investigated in receptor-coupled permeabilized preparations and by fluorimetry of the calcium indicator Fura 2 in intact smooth muscle. The time integral of spontaneous [Ca2+]i transients in the intact rat portal vein was decreased by cyanide and, during tonic contraction, cyanide reduced force without cha