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Stair ascending performance is critical during evacuation from buildings and underground infrastructures. Healthy subjects performed self-paced ascent in three settings: 13 floor building, 31 floor building, 33 m stationary subway escalator. To investigate leg muscle and cardiorespiratory capacities and how they constrain performance, oxygen uptake (VO2), heart rate (HR) and ascending speed were m
Over the last several decades, γ-aminobutyric acid (GABA) has attracted much attention due to its diverse physiological implications in plants, animals, and microorganisms. GABA naturally occurs in plant materials and its concentrations may vary considerably, from traces up to μmol/g (dry basis) depending on plant matrix, germination stage, and processing conditions, among other factors. However,
The spectrum argument purports to show that the better-than relation is not transitive, and consequently that orthodox value theory is built on dubious foundations. The argument works by constructing a sequence of increasingly less painful but more drawn-out experiences, such that each experience in the spectrum is worse than the previous one, yet the final experience is better than the experience
We give a semi-analytical method for the calculation of the transient power and energy dissipated in the cavity walls of an accelerating structure due to the excitation of the higher order modes by a sequence of accelerating bunches. We treat the case where more than one bunch is present in the structure at the same time. The dissipated power is evaluated using the Lagrangian formalism and the dis
Många beteenden hos djur kan vara oflexibla och mer eller mindre ”hard-wired” i hjärnan. Sådana beteenden kan vara ändamålsenliga för regelbundna och rytmiska förändringar i naturen, såsom dag och natt, årstider, etc. Men många faktorer är naturligtvis oförutsägbara i naturen. För sådana oförutsägbara förändringar är det bättre för djur att vara flexibla i sitt beteende. Kognition är en process soThe Paridae (tits, titmice and chickadees) is a bird family consisting of both food hoarding and non-hoarding species. Many studies have been conducted on birds that are considered to be cognitively advanced, such as parrots and corvids, whereas much less is known about these small passerines. In this thesis, I have investigated the cognitive abilities of two members of the Paridae family; marsh t
The formation of neutrophil extracellular traps (NETs) as a host innate immune defence mechanism has been shown to be the result of a novel cell death process called NETosis. The objective of this study was to investigate the role of cholesterol in the formation of NETs. To this end, primary human neutrophils were treated with different concentrations of methy-β-cyclodetxrin (MβCD) to reduce chole
Small wintering passerines adaptively modulate daily body mass acquisition as part of their energy management policy. However, whether birds optimize overnight mass loss or body mass at dawn remains poorly understood. We studied environmental correlates of individual variation in body mass at dusk, overnight mass loss and body mass at dawn in a wild population of Great Tits Parus major wintering i
Although differentiated cells normally retain cell-type-specific gene expression patterns throughout their lifetime, cell identity can sometimes be modified or reversed in vivo by transdifferentiation, or experimentally through cell fusion or by nuclear transfer. To examine the epigenetic changes that are required for the dominant conversion of lymphocytes to muscle, we generated heterokaryons bet
We can trace the beginnings of our knowledge of early Upper Paleolithic (Aurignacian) use of fire to the pioneering 1910–1911 excavations at Abri Blanchard undertaken by Louis Didon and Marcel Castanet. At Blanchard, the excavators recognized and described fire structures that correspond in many ways to features excavated more recently in Western and Central Europe. Here, we address the issue of h
De flesta vattenlevande organismer på Jorden lever i en miljö där de samtidigt måste hantera flera olika hot och stressituationer, såsom t.ex. predation, klimatförändringar och brunifiering. Trots relativt god kunskap om varje stressfaktor för sig, vet man förvånansvärt lite om hur synergier av samtidigt förekommande hot påverkar organismer. Därför har jag i min avhandling undersökt hur predation,Most organisms on Earth live in an environment where they are exposed to multiple pressures, including predation and climate change. In many aquatic ecosystems, organisms have to handle additional challenges such as brownification, co-occurring with climate warming. Despite the growing recognition of impacts of climate warming or brownification on the freshwater communities, little is known on how
The oncogenic D816V mutation of the KIT receptor is well characterized in systemic mastocytosis and acute myeloid leukemia. Although KITD816V has been found in melanoma, its function and involvement in this malignancy is not understood. Here we show that KITD816V induces tyrosine phosphorylation of MITF through a triple protein complex formation between KIT, MITF, and SRC family kinases. In turn,
Reliable verification of damage claims is fundamental to create public trust in the legitimacy of compensation programs, and avoid fraud and moral hazards. However, after decades of using this tool, transparency in verification processes and availability of quantitative information on the accuracy and misidentification rates are unresolved issues. Accurate rules overcome several challenges facing
This case-note analyses the international award recently published in the case of Philip Morris Asia Limited v. The Commonwealth of Australia. Engaging particularly with the application of the Arbitration Tribunal of the abuse of rights doctrine, the note addresses, in the light of this award, a series of questions that continue to perplex international investment lawyers. How should the concept o
Introduction: This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. Methods: Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. Observations were fully prospective for treatment-naïve patients (60% of patients) and partiall
Aromatic L-amino acid decarboxylase (AADC) is an essential enzyme in the synthesis of serotonin, dopamine, and certain trace amines and is present in a variety of organs including the brain and spinal cord. It is previously reported that in mammalian spinal cord AADC cells (called D-cells) were largely confined to a region around the central canal and that they do not produce monoamines. To date,
Objective Low physical fitness and obesity have been associated with higher risk of developing heart failure (HF), but their interactive effects are unknown. Elucidation of interactions among these common modifiable factors may help facilitate more effective primary prevention. Methods We conducted a national cohort study to examine the interactive effects of aerobic fitness, muscular strength and
