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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 193231 sökträffar

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Background: Stress-related disorders are a public health problem and represent a significant burden to individuals and society. It is, therefore, of importance to regard stress in a wider context and identify risk factors not only at work but in all occupations in everyday life, to prevent ill health. Aim/objective: The aim of this study was to examine potential associations between everyday occup

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The literature on economic geography suffers from a lack of attention to the emergence of new industries. Recent literature on "regional branching" proposes that new industries emerge in regions where preexisting economic activities are technologically related to the emerging industry. This article provides a more grounded basis for the emerging literature on regional branching by confronting the

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Objectives Whether the increased risk of comorbidities, such as cardiovascular disease, in rheumatoid arthritis (RA) can be reverted by particular antirheumatic therapies, or response to these, is unclear but of critical clinical importance. We wanted to investigate whether response to tumour necrosis factor inhibitors (TNFi) translates into a reduced risk for acute coronary syndrome (ACS). Method

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The temperature and density profiles of protoplanetary discs depend crucially on the mass fraction of micrometre-sized dust grains and on their chemical composition. A larger abundance of micrometre-sized grains leads to an overall heating of the disc, so that the water ice line moves further away from the star. An increase in the water fraction inside the disc, maintaining a fixed dust abundance,

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An increasing body of literature explores the role of transnational municipal networks (TMNs) in governing sustainable development. As associations, one key task of TMNs is to represent their members through production and dissemination of information and knowledge concerning municipal action for sustainable development. Case studies, often emphasising best practice, are used by many TMNs to fulfi

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The outcome of Design, Innovation and Product development research is often manifested as recommendations in the form of methods, but these do not always find their way into industrial application. This paper elaborates on drivers and barriers for the spread of product development methodology based on 41 interviews with managers, designers, developers and knowledge brokers. Results indicate a rang

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Increasingly the material research deals with is cast as data. This is an ambiguous concept, which describes the matter of research in all stages of the research process. From having been seen as a stepping-stone on the way to producing the scientific results, increasingly data is itself positioned as the result. At the same time demands for data preservation and open data are often motivated with

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In the modern age of mediated visibility, media scandal is an immense risk that threatens to destroy the lives of people who have become the focus of public attention. The paper is concerned with the question of how the individual is affected by the attention when the media hype a story. Empirically, it is based upon in-depth interviews with Swedish persons who have been in the epicenter of scanda

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Agricultural residues, such as wheat straw, are feasible substrates for ethanol fermentation provided that pentoses and hexoses can be converted efficiently. Separate hydrolysis and cofermentation (SHCF) constitute a framework for improvement of conversion efficiency, because it permits independent optimization of the enzymatic hydrolysis and cofermentation steps. A drawback is that the high gluco

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Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a trip

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This study investigated context-dependent episodic memory retrieval. An influential idea in the memory literature is that performance benefits when the retrieval context overlaps with the original encoding context. However, such memory facilitation may not be driven by the encoding-retrieval overlap per se but by the presence of diagnostic features in the reinstated context that discriminate the t

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Background: Tyrosine kinase inhibitors (TKIs) have increased survival dramatically for patients with chronic myeloid leukemia (CML), but continuous administration of these drugs may elicit long-term toxicity. Objective: To investigate the incidence of vascular events in patients with CML treated with first-and second-generation TKIs. Design: Retrospective cohort study using nationwide population-b

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During substrate-limited growth, some strains of Thiosphaera pantotropha nitrify heterotrophically and denitrify aerobically. These processes are thought to be used as NADH overflow mechanisms, resulting from a restricted oxygen respiration capacity. In this study, the behavior of T. pantotropha regarding the NADH overflow in the presence of substantial concentrations of substrate was examined. Co