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The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abu
The report draws on socio-legal theory in relation to growing concerns over fairness, accountability and transparency of societally applied artificial intelligence (AI) and machine learning. The purpose is to contribute to a broad socio-legal orientation by describing legal and normative challenges posed by applied AI. To do so, the article first analyses a set of problematic cases, e.g. image rec
The androgen insensitivity syndrome is a disorder caused by deficient function of the androgen receptor, characterized by varying degrees of undermasculinization in karyotypic males. We have identified four mutations in the androgen receptor gene, in the region encoding the DNA-binding domain of the protein. Two mutations, R607X and R615G, were found in patients with complete insensitivity to andr
Our study combined size and timing of the first local recurrence to create a growth rate index (GRI- ratio of size (cm) to timing (mo)) which we analyzed for an association with metastasis. We analyzed 134 locally recurrent tumors from a series of 460 adult patients with soft tissue sarcoma of the extremities and trunk wall who were diagnosed and treated between 1964 and 1990, with a median follow
AIMS: Using functional magnetic resonance imaging (fMRI) we investigated the cortical and subcortical representations during bladder filling and the effect of simultaneous stimulation of the dorsal clitoral nerve on these cortical and subcortical structures.METHODS: After approval of the local ethics committee, 8 healthy females were included. Prior to scanning, subjects were catheterized and the
Bacterial cell division is orchestrated by the Z ring, which is formed by single-stranded treadmilling protofilaments of FtsZ. In Streptomyces, during sporulation, multiple Z rings are assembled and lead to formation of septa that divide a filamentous hyphal cell into tens of prespore compartments. We describe here mutant alleles of ftsZ in Streptomyces coelicolor and Streptomyces venezuelae that
Abstract: Noradrenaline (NA) metabolism tn the neocortex and hippocampus was examined in rats atl 1, 24, and 48 h following 15 min of reversible forebrain ischemia. As assessed by the ratio of accumulated 3,4‐dihydroxyphenylalanine (DOPA) to the tissue NA level after inhibition of DOPA decarboxylase, the NA turnover rates were markedly increased (120‐148% above the control) at 1 h postischemia in
The effects of intracameral injections of cholecystokinin (CCK) on the pupil size were determined in monkeys, cats, rabbits, rats and guinea-pigs. In animals under muscarinic cholinergic blockade, CCK caused miosis in monkeys but not in the other species investigated. In monkeys CCK-8 was more potent than CCK-33, which was, however, much more potent than non-sulphated CCK-8. These observations ind
Abstract in Norwegian Den kalde krigens slutt og Sovjetunionens fall har gjort det lettere for personlige kontakter på tvers av de «gamle grenser». Økt migrasjon fra det tidligere Sovjet, samt fra de nye statene i Sentral- og Øst-Europa, er et kjennetegn på den postsosialistiske perioden. Denne statistisk målbare forandringen har også fått følger på det diskursive planet. Migrasjonsproblematikken
Popular Abstract in Swedish Syftet med avhandlingen är att undersöka bondeskapets (the peasantry)framtida existens. Analysen görs på global nivå, men framför allt på lokal nivå i samband med implikationerna av Mexikos nya jordreform från 1992. Bonden dekonstrueras i ekonomisk-och sociopolitisk aktör för att belysa hans/hennes complexitet. Försörjningsstrategier i tider då staten ersätts av markandThe thesis deals with a classical issue, that of the fate of the peasantry, in particular the process of the transformation of the peasantry. The aim is to explore whether there is a place for the smallholding peasantry in the future, or if the process of dissolution is inevitable. The discussion of this broad question is approached by first deconstructing the peasantry into economic actors and so
The prevailing view that eukaryotic cells are restrained from intercellular exchange of genetic information has been challenged by recent reports on nanotubes, exosomes, apoptotic bodies, and nucleic acid-binding peptides that provide novel pathways for cell-cell communication, with implications in health and disease.
BACKGROUND: Neutrophils and reactive oxygen species (ROS) are suggested to be involved in irreversible myocardial reperfusion injury and stunning. We investigated the relations between circulating biochemical markers and myocardium at risk (MaR), myocardial infarct (MI) size, salvage, and recovery of function in man. METHODS AND RESULTS: In patients undergoing PCI serial blood samples were acquir
PURPOSE: The purpose of the present study was to compare retinal function between the perifoveal nasal and perifoveal temporal areas of diabetic eyes using multifocalERG (mfERG). METHODS: We included 36 eyes from 27 patients with diabetes (age 58 ± 14 years; duration of diabetes 13 ± 9 years; HbA(1c) 7.1 ± 1.8%) and a control group with 18 eyes from 18 healthy subjects (age 57 ± 11 years). Retin
The aim of the present study was to investigate the distribution of suicide attempts across the depressive episodes in suicides and controls with a severe depression. A blind record evaluation was performed of 100 suicide victims and matched controls admitted to the Department of Psychiatry between 1956 and 1969 and monitored to 2006. There was a similar number of episodes in suicides and controls
INTRODUCTION: Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second receptor, PTHR2, has been identified although its function is comparatively unkn
