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Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) pop
In this contribution, a thermodynamically consistent and mathematically canonical modelling framework for the investigation of the cyclic thermomechanical behaviour of Nickel-Titanium shape memory alloy wires is developed. Particular focus is placed on the self-heating of the material subjected to multiple load cycles. The relatively high load rates necessitates the consideration of inertia terms,
BackgroundApproximately 15 % of surgical patients in hospital are affected of an adverse event, which is a medical error caused by the health care system. Laparoscopy is the preferred surgical technique in common procedures. Societal changes with shorter working hours, patient safety and ethics demand optimisation of resources toachieve the goal of educating competent surgeons within a reasonable
Chronic pruritus is a frequently occurring symptom of various dermatoses that causes a high burden and impaired quality of life. An effective anti pruritic therapy is important for the patient, but its effectiveness is difficult to evaluate. Diverse methods and interpretations of pruritic metrics are utilized in clinical trials and the daily clinical practice in different countries, resulting in d
Directional crack growth criteria in compressed elastic–plastic materials are considered. The conditions at the crack tip are evaluated for a straight stationary crack. Remote load is a combined hydrostatic stress and pure shear, applied via a boundary layer assuming small scale yielding. Strains and deformations are assumed to be small. Different candidates for crack path criteria are examined. M
Any reasonable model of sedimentation contains the nonlinear hindered-settling flux function. If one assumes ideal conditions and no compression, then there exist several theoretically possible ways of identifying a large part of the flux function from only one experiment by means of formulas derived from the theory of partial differential equations. Such identification methods, including new resu
Urban rivers in Asian developing countries are becoming increasingly polluted due to industrialization and lacking treatment of wastewater. We investigated toxicity and likely sources of pollutants for the urban Shitalakshaya River, Bangladesh. Physiochemical variables and heavy metals were examined in water and sediment of an urban river section in Narayanganj City. The spatial distribution of qu
Objective: To locate components and target proteins of relevance for the cAMP and cGMP signaling networks including cAMP and cGMP phosphodiesterases (PDEs), salt-inducible kinases (SIKs), subunits of Na+, K+-ATPases, and aquaporins (AQPs) in the human saccule. Methods: The human saccule was dissected out during the removal of vestibular schwannoma via the translabyrinthine approach and immediately
The first online segmentation multi-target tracking algorithm with reported real-time speeds is presented. Based on the popular and fast bounding box based tracker SORT, our method called SORTS is able to utilize segmentations for tracking while keeping the real-time speeds. To handle occlusions, which neither SORT nor SORTS do, we also present SORTS+RReID, an optional extension which uses ReID ve
C1q deficiency is a rare condition associated with a systemic lupus erythematosus (SLE)-like syndrome and recurrent infections. Here we present the molecular basis behind C1q deficiency in three sisters of Inuit origin. Initial examination for complement deficiency showed no function of the classical complement activation pathway in the patients; the lectin and alternative pathways were intact. No
Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicatin
This doctoral thesis delves into the transformation of the customer journey—that is, the direct and indirect interactions between a customer and retailer over time—in the smartphone era. Using a socio-material perspective, it goes beyond current visions of the customer journey, which often focus on emotions and experiences, and instead explores how agency is distributed across elements that includ
Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death. Despite heritability estimates of 52%, genome-wide association studies (GWASs) have discovered relatively few loci. We developed a machine learning approach called RefMap, which integrates functional genomics with GWAS summary statistics for gene discovery. With transcriptomic and epigenetic profiling of mot
An experimental and computational study of the near-wall combustion in a Homogeneous Charge Compression Ignition (HCCI) engine has been conducted by applying laser based diagnostic techniques in combination with numerical modeling. Our major intent was to characterize the combustion in the velocity- and thermal boundary layers. The progress of the combustion was studied by using fuel tracer LIF, t
Biosynthesis of decorin was investigated by incubating a rat fibroblast cell line with various radiolabelled protein and galactosaminoglycan precursors. The following cell-associated and distinct intermediates were isolated and identified: a pool of non-glycosylated core protein, two pools of decorin with incomplete chains, one with three sulphated disaccharide repeats and another with five or mor
IT-samordnare Kontaktinformation E-post: margareta [dot] hellstrom [at] mgeo [dot] lu [dot] se Telefon: +46 46 222 86 96 Mobil: +46 72 749 98 14Organisation Miljö- och geovetenskapliga institutionen (MGeo) Besöksadress: Sölvegatan 12, Lund Rumsnummer: 287 Hämtställe: 16 WebbplatsMargareta Hellströms profil i Lunds universitets forskningsportalAndra roller Forskare Miljö- och geovetenskapliga insti
https://www.nateko.lu.se/sv/margareta-hellstrom - 2026-06-28
