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Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selective vulnerability of global brain networks to neurodegenerative pathology. Using task-free functional ma
Half the global soil carbon (C) is held in high-latitude systems. Climate change will expose these to warming and a shift towards plant communities with more labile C input. Labile C can also increase the rate of loss of native soil organic matter (SOM); a phenomenon termed ‘priming’. We investigated how warming (+1.1 °C over ambient using open top chambers) and litter addition (90 g m−2 yr−1) tre
Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in the presence of insulin resistance. We assessed whether glucagon is also involved in the adaptation to insulin resistance. A total of 1,437 individuals underwent an oral glucose tolerance test with measurements of circulating glucose, insulin, and glucagon concentrations at 0, 30 and 120 min. Early glucagon
The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. If too many leukocytes are recruited, normal, not injured, cells can be damaged; a process known from chronic inflammatory diseases such as reumatoid arthritis,
Popular Abstract in Swedish Hjärtkärlsjukdomar brukar definieras som ateriosklerotiska och tromboemboliska förändringar i hjärta, hjärna och i den arteriella blodcirkulationen. Dessa sjukdomar är mycket vanliga, och i Sverige insjuknar ca 40 000 personer i hjärtinfarkt och c 35 000 i hjärnblödning per år. Trots att det skett en sänkning av både incidens och dödlighet för dessa sjukdomar i västvärlThe Cardiovascular Risk Factor Study in Southern Sweden, CRISS, was initiated to explore if men at increased risk at developing CVD risk factors can be identified already before age 40. Starting in 1990 two birth cohorts of men residing in Helsingborg, Sweden, were surveyed at age 37 (n=991, participation rate 68%), at age 40 (n=770) and age 43 (n=702), respectively. A study questionnaire, a physi
Climate change and disasters are among today’s most pressing issues. The damage caused by the world-wide increase in disasters is staggering, with the urban poor being most at risk. Disasters make their al-ready precarious living conditions worse, creating a vicious circle of poverty. More and more attention has thus been given to the need to address changing climatic conditions and disaster risk
Popular Abstract in Swedish Den här avhandlingen handlar om kryptering, strömchiffer, metoder för att analysera (knäcka) och konstruera bättre chiffer. Det finns flera olika metoder för att hemliggöra meddelanden. Det klassiska sättet är att två personer som vill kommunicera delar en hemlig nyckel som används för att både kryptera och dekryptera meddelanden. Denna metod kallas symmetrisk krypteriStream ciphers are cryptographic primitives used to ensure privacy in digital communication. In this thesis we focus on stream ciphers built using Linear Feedback Shift Registers (LFSRs). Several different stream ciphers are analysed and new attacks are presented. In addition, two new stream ciphers are presented, both based on the same design. The first attack is performed on SOBER-t16 and SOBER
BACKGROUND: Risk models to predict prostate cancer on biopsy, whether they include only prostate-specific antigen (PSA) or other markers, are intended for use in all men of screening age. However, the association between PSA and cancer probably depends on a man's recent screening history. METHODS: The authors examined the effect of prior screening on the ability to predict the risk of prostate can
Names of taxa referred to Hieracium sect. Alpestria (including the ‘Semidovrensia group’), Foliosa and Prenanthoidea and reported from Sweden have been compiled from the literature and herbaria and all uses have been indexed. Based on this synopsis, the nomenclatural validity and legitimacy of the names are analysed. In total, the use of 75, 62 and 27 names is documented for the three sections, re
During the last century (1900s) industrialized forms of agriculture and human activities have caused eutrophication of Baltic Sea waters. As a consequence, the hypoxic zone in the Baltic Sea has increased, especially during the last 50 years, and has caused severe ecosystem disturbance. Climate forcing has been proposed to be responsible for the reported trends in hypoxia (< 2 mg/l O-2) both durin
In light of the emerging diabetes epidemic, new experimental approaches in islet research are needed to elucidate the mechanisms behind pancreatic islet dysfunction and to facilitate the development of more effective therapies. Optogenetics has created numerous new experimental tools enabling us to gain insights into processes little was known about before. The spatial and temporal precision that
Phenological changes among plants due to climate change are well documented, but often hard to interpret. In order to assess the adaptive value of observed changes, we study how annual plants with and without growth constraints should optimize their flowering time when productivity and season length changes. We consider growth constraints that depend on the plant's vegetative mass: self-shading, c
We report on a full-Holocene pollen, charcoal and macrofossil record from a small forest hollow in Gribskov, eastern Denmark. The Fagus sylvatica pollen record suggests the establishment of a small Fagus population at Gribskov in the early Holocene together with early establishment of other thermophilous broadleaved trees, including Quercus sp., Tilia sp. and Ulmus sp. The macrofossils contribute
We examined how radiation dose levels in digital breast tomosynthesis (DBT) differ from those used in 2-view full-field digital mammography (FFDM). Acquisition parameter settings and information on the average absorbed dose to the glandular tissues within the breasts were reviewed based on clinical studies that evaluated DBT and FFDM. Dose ratios (DDBT/DFFDM) were derived from imaging protocols, w
Background and AimsApomictic species (with asexual seed production) make up for 20-50 % of all taxonomically recognized species in northern Europe, but the phylogenetic relationships of apomictic species and the mode of evolution and speciation remain largely unknown and their taxonomy is consequently disputed.MethodsIn the present study, plastid psbD-trnT sequences (349 accessions) and 12 nuclear
